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Vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2: A scoping review.
PLoS One. 2021; 16(4):e0250196.Plos

Abstract

INTRODUCTION

The evidence for vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is not well established. Therefore, the objective of this review is to summarize emerging evidence on the vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2.

METHODS

We conducted a systematic search in PubMed, CINAHL, Web of Science, SCOPUS, and CENTRAL. Likewise, a search for preprint publications was conducted using MedRxiv and Research Square. Studies that addressed vertical transmission of SARS-CoV-2 (concept) among pregnant women infected by Covid-19 (population) in any setting (community, hospital, or home) in any country or context were considered for inclusion. Any types of studies or reports published between December 2019 and September 2020 addressing the effects of SARS-CoV-2 on pregnant women and their newborn babies were included. Studies were screened for eligibility against the inclusion criteria for the review by two reviewers.

RESULTS

We identified 51 studies reporting 336 newborns screened for COVID-19. From the 336 newborns screened for COVID-19, only 15 (4.4%) were positive for throat swab RT-PCR. All neonates with positive throat swab RT-PCR were delivered by cesarean section. Among neonates with throat swab SARS-CoV-2 positive only five (33.3%) had concomitant placenta, amniotic fluid, and cord blood samples tested, of which only one amniotic fluid sample is positive for RT PCR. Five neonates had elevated IgG and IgM but without intrauterine tissue tested. Four neonates had chest imaging suggestive of COVID-19 pneumonia.

CONCLUSION

Currently there is not enough evidence on vertical virologic transmission of COVID-19 infection during the third trimester of pregnancy. Additionally, there is no evidence to support cesarean delivery, abstaining from breast feeding nor mother and infant separation. Further research involving an adequate sample size of breast milk, placenta, amniotic fluid, and cord blood to ascertain the possibility of vertical transmission and breast milk transfer is needed.

Authors+Show Affiliations

Saint Paul's Hospital Millennium Medical College, Department of Obstetrics and Gynaecology, Addis Ababa, Ethiopia.Dornsife School of Public Health, Drexel University, Philadelphia, PA, United States of America.Dornsife School of Public Health, Drexel University, Philadelphia, PA, United States of America.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

33886645

Citation

Tolu, Lemi Belay, et al. "Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2: a Scoping Review." PloS One, vol. 16, no. 4, 2021, pp. e0250196.
Tolu LB, Ezeh A, Feyissa GT. Vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2: A scoping review. PLoS One. 2021;16(4):e0250196.
Tolu, L. B., Ezeh, A., & Feyissa, G. T. (2021). Vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2: A scoping review. PloS One, 16(4), e0250196. https://doi.org/10.1371/journal.pone.0250196
Tolu LB, Ezeh A, Feyissa GT. Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2: a Scoping Review. PLoS One. 2021;16(4):e0250196. PubMed PMID: 33886645.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2: A scoping review. AU - Tolu,Lemi Belay, AU - Ezeh,Alex, AU - Feyissa,Garumma Tolu, Y1 - 2021/04/22/ PY - 2020/05/26/received PY - 2021/03/30/accepted PY - 2021/4/22/entrez PY - 2021/4/23/pubmed PY - 2021/5/5/medline SP - e0250196 EP - e0250196 JF - PloS one JO - PLoS One VL - 16 IS - 4 N2 - INTRODUCTION: The evidence for vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is not well established. Therefore, the objective of this review is to summarize emerging evidence on the vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2. METHODS: We conducted a systematic search in PubMed, CINAHL, Web of Science, SCOPUS, and CENTRAL. Likewise, a search for preprint publications was conducted using MedRxiv and Research Square. Studies that addressed vertical transmission of SARS-CoV-2 (concept) among pregnant women infected by Covid-19 (population) in any setting (community, hospital, or home) in any country or context were considered for inclusion. Any types of studies or reports published between December 2019 and September 2020 addressing the effects of SARS-CoV-2 on pregnant women and their newborn babies were included. Studies were screened for eligibility against the inclusion criteria for the review by two reviewers. RESULTS: We identified 51 studies reporting 336 newborns screened for COVID-19. From the 336 newborns screened for COVID-19, only 15 (4.4%) were positive for throat swab RT-PCR. All neonates with positive throat swab RT-PCR were delivered by cesarean section. Among neonates with throat swab SARS-CoV-2 positive only five (33.3%) had concomitant placenta, amniotic fluid, and cord blood samples tested, of which only one amniotic fluid sample is positive for RT PCR. Five neonates had elevated IgG and IgM but without intrauterine tissue tested. Four neonates had chest imaging suggestive of COVID-19 pneumonia. CONCLUSION: Currently there is not enough evidence on vertical virologic transmission of COVID-19 infection during the third trimester of pregnancy. Additionally, there is no evidence to support cesarean delivery, abstaining from breast feeding nor mother and infant separation. Further research involving an adequate sample size of breast milk, placenta, amniotic fluid, and cord blood to ascertain the possibility of vertical transmission and breast milk transfer is needed. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/33886645/Vertical_transmission_of_Severe_Acute_Respiratory_Syndrome_Coronavirus_2:_A_scoping_review_ L2 - https://dx.plos.org/10.1371/journal.pone.0250196 DB - PRIME DP - Unbound Medicine ER -