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Nanoparticle composite TPNT1 is effective against SARS-CoV-2 and influenza viruses.
Sci Rep. 2021 04 22; 11(1):8692.SR

Abstract

A metal nanoparticle composite, namely TPNT1, which contains Au-NP (1 ppm), Ag-NP (5 ppm), ZnO-NP (60 ppm) and ClO2 (42.5 ppm) in aqueous solution was prepared and characterized by spectroscopy, transmission electron microscopy, dynamic light scattering analysis and potentiometric titration. Based on the in vitro cell-based assay, TPNT1 inhibited six major clades of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with effective concentration within the range to be used as food additives. TPNT1 was shown to block viral entry by inhibiting the binding of SARS-CoV-2 spike proteins to the angiotensin-converting enzyme 2 (ACE2) receptor and to interfere with the syncytium formation. In addition, TPNT1 also effectively reduced the cytopathic effects induced by human (H1N1) and avian (H5N1) influenza viruses, including the wild-type and oseltamivir-resistant virus isolates. Together with previously demonstrated efficacy as antimicrobials, TPNT1 can block viral entry and inhibit or prevent viral infection to provide prophylactic effects against both SARS-CoV-2 and opportunistic infections.

Authors+Show Affiliations

Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, No. 1, Sec. 1, Ren-Ai Rd., Taipei, 10002, Taiwan. Department of Laboratory Medicine, National Taiwan University Hospital, Chung-Shan South Rd., No. 7, Taipei, 10002, Taiwan.Department and Graduate Institute of Microbiology and Immunology, National Defense Medical Center, Taipei, 11490, Taiwan.Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, No. 1, Sec. 1, Ren-Ai Rd., Taipei, 10002, Taiwan.Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, No. 1, Sec. 1, Ren-Ai Rd., Taipei, 10002, Taiwan.Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, No. 1, Sec. 1, Ren-Ai Rd., Taipei, 10002, Taiwan.Tripod Nano Technology, No. 171, Sec. 1, Mei Shi Rd., Yang Mei District, Taoyuan, 32656, Taiwan.Tripod Nano Technology, No. 171, Sec. 1, Mei Shi Rd., Yang Mei District, Taoyuan, 32656, Taiwan.Tripod Nano Technology, No. 171, Sec. 1, Mei Shi Rd., Yang Mei District, Taoyuan, 32656, Taiwan.The Genomics Research Center, Academia Sinica, No. 128, Sec. 2, Academia Rd., Taipei, 11529, Taiwan.The Genomics Research Center, Academia Sinica, No. 128, Sec. 2, Academia Rd., Taipei, 11529, Taiwan. jmfang@ntu.edu.tw. Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, 10607, Taiwan. jmfang@ntu.edu.tw.Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7, Chung-Shan South Rd., Taipei, 10002, Taiwan. pcyang@ntu.edu.tw. Institute of Biomedical Sciences, Academia Sinica, No. 128, Sec. 2, Academia Rd., Taipei, 11529, Taiwan. pcyang@ntu.edu.tw.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33888738

Citation

Chang, Sui-Yuan, et al. "Nanoparticle Composite TPNT1 Is Effective Against SARS-CoV-2 and Influenza Viruses." Scientific Reports, vol. 11, no. 1, 2021, p. 8692.
Chang SY, Huang KY, Chao TL, et al. Nanoparticle composite TPNT1 is effective against SARS-CoV-2 and influenza viruses. Sci Rep. 2021;11(1):8692.
Chang, S. Y., Huang, K. Y., Chao, T. L., Kao, H. C., Pang, Y. H., Lu, L., Chiu, C. L., Huang, H. C., Cheng, T. R., Fang, J. M., & Yang, P. C. (2021). Nanoparticle composite TPNT1 is effective against SARS-CoV-2 and influenza viruses. Scientific Reports, 11(1), 8692. https://doi.org/10.1038/s41598-021-87254-3
Chang SY, et al. Nanoparticle Composite TPNT1 Is Effective Against SARS-CoV-2 and Influenza Viruses. Sci Rep. 2021 04 22;11(1):8692. PubMed PMID: 33888738.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nanoparticle composite TPNT1 is effective against SARS-CoV-2 and influenza viruses. AU - Chang,Sui-Yuan, AU - Huang,Kuo-Yen, AU - Chao,Tai-Ling, AU - Kao,Han-Chieh, AU - Pang,Yu-Hao, AU - Lu,Lin, AU - Chiu,Chun-Lun, AU - Huang,Hsin-Chang, AU - Cheng,Ting-Jen Rachel, AU - Fang,Jim-Min, AU - Yang,Pan-Chyr, Y1 - 2021/04/22/ PY - 2020/07/28/received PY - 2021/03/25/accepted PY - 2021/4/23/entrez PY - 2021/4/24/pubmed PY - 2021/5/1/medline SP - 8692 EP - 8692 JF - Scientific reports JO - Sci Rep VL - 11 IS - 1 N2 - A metal nanoparticle composite, namely TPNT1, which contains Au-NP (1 ppm), Ag-NP (5 ppm), ZnO-NP (60 ppm) and ClO2 (42.5 ppm) in aqueous solution was prepared and characterized by spectroscopy, transmission electron microscopy, dynamic light scattering analysis and potentiometric titration. Based on the in vitro cell-based assay, TPNT1 inhibited six major clades of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with effective concentration within the range to be used as food additives. TPNT1 was shown to block viral entry by inhibiting the binding of SARS-CoV-2 spike proteins to the angiotensin-converting enzyme 2 (ACE2) receptor and to interfere with the syncytium formation. In addition, TPNT1 also effectively reduced the cytopathic effects induced by human (H1N1) and avian (H5N1) influenza viruses, including the wild-type and oseltamivir-resistant virus isolates. Together with previously demonstrated efficacy as antimicrobials, TPNT1 can block viral entry and inhibit or prevent viral infection to provide prophylactic effects against both SARS-CoV-2 and opportunistic infections. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/33888738/Nanoparticle_composite_TPNT1_is_effective_against_SARS-CoV-2_and_influenza_viruses. L2 - https://doi.org/10.1038/s41598-021-87254-3 DB - PRIME DP - Unbound Medicine ER -