TY - JOUR T1 - Association of leptospirosis and scrub typhus in acute encephalitis syndrome in a tertiary care hospital in Odisha, India. AU - Das,Bidyut Kumar, AU - Mohanty,Sriprasad, AU - Sahoo,Prakash Kumar, PY - 2020/11/10/received PY - 2021/02/18/revised PY - 2021/03/30/accepted PY - 2021/4/24/pubmed PY - 2021/10/1/medline PY - 2021/4/23/entrez KW - Odisha KW - acute encephalitis syndrome KW - leptospirosis KW - scrub typhus SP - 1088 EP - 1090 JF - Transactions of the Royal Society of Tropical Medicine and Hygiene JO - Trans R Soc Trop Med Hyg VL - 115 IS - 9 N2 - BACKGROUND: Acute encephalitis syndrome (AES) is a major public health concern in India, causing febrile illness principally associated with viral infection. Bacteria-like scrub typhus and leptospirosis also cause acute febrile illness. Therefore, this study was conceived to address the possible etiological agents contributing to sporadic AES in a tertiary care center in Odisha, India. METHOD: This was a prospective hospital-based study that enrolled 92 consecutive patients with clinically diagnosed AES whose blood/cerebrospinal fluid samples were tested for IgM antibodies to dengue, Japanese encephalitis (JE), herpes simplex virus (HSV), Epstein-Barr virus (EBV), leptospirosis and scrub typhus. RESULTS: Viral antibodies to dengue were detected in three (3.26%) cases, HSV1 in four (4.34%) and HSV2 in three (3.26%) cases. Significantly, antibodies to EBV in 22 (23.591%) and to JE in 27 (29.34%) cases were detected. Notably, 30 (32.60%) and 11(12.0%) of patients had IgM antibodies to leptospirosis and scrub typhus, respectively. CONCLUSION: This observation indicates an association of leptospirosis and scrub typhus infection in sporadic cases of AES, besides other viruses. SN - 1878-3503 UR - https://www.unboundmedicine.com/medline/citation/33891701/Association_of_leptospirosis_and_scrub_typhus_in_acute_encephalitis_syndrome_in_a_tertiary_care_hospital_in_Odisha_India_ DB - PRIME DP - Unbound Medicine ER -