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Clinical course, radiological findings and late outcome in preterm infant with suspected vertical transmission born to a mother with severe COVID-19 pneumonia: a case report.
J Med Case Rep. 2021 Apr 23; 15(1):213.JM

Abstract

BACKGROUND

Vertical transmission of coronavirus disease 2019 (COVID-19) from mother to newborn infant is doubtful, and very little is known about disease severity and neonatal outcome.

CASE PRESENTATION

We present a preterm Iranian infant born to a Persian mother with severe COVID-19 pneumonia. The mother underwent cesarean delivery, and amniotic fluid yielded a positive result for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by real-time reverse transcription polymerase chain reaction (RT-PCR). The newborn infant showed early-onset infection with SARS-CoV-2 confirmed on pharyngeal swabs by RT-PCR assay within 24 hours after birth, suggesting vertical transmission. Unfortunately, the mother died 14 days after delivery. We describe the clinical course and outcome of the infant up to 7 months of age.

CONCLUSION

COVID-19 infection in pregnant women may increase maternal morbidity, mortality and possibly vertical transmission in severe cases. However, it does not seem to progress to serious early or late neonatal complications.

Authors+Show Affiliations

Pediatrics infectious diseases research center, Mazandaran University of Medical Sciences, Sari, Iran. dr.royafarhadi@gmail.com.Pediatrics infectious diseases research center, Mazandaran University of Medical Sciences, Sari, Iran.Pediatrics infectious diseases research center, Mazandaran University of Medical Sciences, Sari, Iran.Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.Department of Obstetrics and Gynecology, Mazandaran University of Medical Sciences, Sari, Iran.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

33892788

Citation

Farhadi, Roya, et al. "Clinical Course, Radiological Findings and Late Outcome in Preterm Infant With Suspected Vertical Transmission Born to a Mother With Severe COVID-19 Pneumonia: a Case Report." Journal of Medical Case Reports, vol. 15, no. 1, 2021, p. 213.
Farhadi R, Mehrpisheh S, Ghaffari V, et al. Clinical course, radiological findings and late outcome in preterm infant with suspected vertical transmission born to a mother with severe COVID-19 pneumonia: a case report. J Med Case Rep. 2021;15(1):213.
Farhadi, R., Mehrpisheh, S., Ghaffari, V., Haghshenas, M., & Ebadi, A. (2021). Clinical course, radiological findings and late outcome in preterm infant with suspected vertical transmission born to a mother with severe COVID-19 pneumonia: a case report. Journal of Medical Case Reports, 15(1), 213. https://doi.org/10.1186/s13256-021-02835-0
Farhadi R, et al. Clinical Course, Radiological Findings and Late Outcome in Preterm Infant With Suspected Vertical Transmission Born to a Mother With Severe COVID-19 Pneumonia: a Case Report. J Med Case Rep. 2021 Apr 23;15(1):213. PubMed PMID: 33892788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical course, radiological findings and late outcome in preterm infant with suspected vertical transmission born to a mother with severe COVID-19 pneumonia: a case report. AU - Farhadi,Roya, AU - Mehrpisheh,Shahrokh, AU - Ghaffari,Vajiheh, AU - Haghshenas,Mohammadreza, AU - Ebadi,Aghdas, Y1 - 2021/04/23/ PY - 2020/11/24/received PY - 2021/03/29/accepted PY - 2021/4/24/entrez PY - 2021/4/25/pubmed PY - 2021/4/30/medline KW - COVID-19 KW - Neonate KW - Preterm infant KW - SARS-CoV-2 KW - Vertical transmission SP - 213 EP - 213 JF - Journal of medical case reports JO - J Med Case Rep VL - 15 IS - 1 N2 - BACKGROUND: Vertical transmission of coronavirus disease 2019 (COVID-19) from mother to newborn infant is doubtful, and very little is known about disease severity and neonatal outcome. CASE PRESENTATION: We present a preterm Iranian infant born to a Persian mother with severe COVID-19 pneumonia. The mother underwent cesarean delivery, and amniotic fluid yielded a positive result for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by real-time reverse transcription polymerase chain reaction (RT-PCR). The newborn infant showed early-onset infection with SARS-CoV-2 confirmed on pharyngeal swabs by RT-PCR assay within 24 hours after birth, suggesting vertical transmission. Unfortunately, the mother died 14 days after delivery. We describe the clinical course and outcome of the infant up to 7 months of age. CONCLUSION: COVID-19 infection in pregnant women may increase maternal morbidity, mortality and possibly vertical transmission in severe cases. However, it does not seem to progress to serious early or late neonatal complications. SN - 1752-1947 UR - https://www.unboundmedicine.com/medline/citation/33892788/Clinical_course_radiological_findings_and_late_outcome_in_preterm_infant_with_suspected_vertical_transmission_born_to_a_mother_with_severe_COVID_19_pneumonia:_a_case_report_ L2 - https://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-021-02835-0 DB - PRIME DP - Unbound Medicine ER -