Tags

Type your tag names separated by a space and hit enter

The Female Vaginal Microbiome in Health and Bacterial Vaginosis.
Front Cell Infect Microbiol. 2021; 11:631972.FC

Abstract

The vaginal microbiome is an intricate and dynamic microecosystem that constantly undergoes fluctuations during the female menstrual cycle and the woman's entire life. A healthy vaginal microbiome is dominated by Lactobacillus which produce various antimicrobial compounds. Bacterial vaginosis (BV) is characterized by the loss or sharp decline in the total number of Lactobacillus and a corresponding marked increase in the concentration of anaerobic microbes. BV is a highly prevalent disorder of the vaginal microbiota among women of reproductive age globally. BV is confirmed to be associated with adverse gynecologic and obstetric outcomes, such as sexually transmitted infections, pelvic inflammatory disease, and preterm birth. Gardnerella vaginalis is the most common microorganism identified from BV. It is the predominant microbe in polymicrobial biofilms that could shelter G. vaginalis and other BV-associated microbes from adverse host environments. Many efforts have been made to increase our understanding of the vaginal microbiome in health and BV. Thus, improved novel and accurate diagnosis and therapeutic strategies for BV have been developed. This review covers the features of vaginal microbiome, BV, BV-associated diseases, and various strategies of diagnosis and treatment of BV, with an emphasis on recent research progresses.

Authors+Show Affiliations

Department of Clinical Laboratory, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, China.Department of Clinical Laboratory, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, China.Department of Clinical Laboratory, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, China.Department of Clinical Laboratory, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

33898328

Citation

Chen, Xiaodi, et al. "The Female Vaginal Microbiome in Health and Bacterial Vaginosis." Frontiers in Cellular and Infection Microbiology, vol. 11, 2021, p. 631972.
Chen X, Lu Y, Chen T, et al. The Female Vaginal Microbiome in Health and Bacterial Vaginosis. Front Cell Infect Microbiol. 2021;11:631972.
Chen, X., Lu, Y., Chen, T., & Li, R. (2021). The Female Vaginal Microbiome in Health and Bacterial Vaginosis. Frontiers in Cellular and Infection Microbiology, 11, 631972. https://doi.org/10.3389/fcimb.2021.631972
Chen X, et al. The Female Vaginal Microbiome in Health and Bacterial Vaginosis. Front Cell Infect Microbiol. 2021;11:631972. PubMed PMID: 33898328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Female Vaginal Microbiome in Health and Bacterial Vaginosis. AU - Chen,Xiaodi, AU - Lu,Yune, AU - Chen,Tao, AU - Li,Rongguo, Y1 - 2021/04/07/ PY - 2020/11/26/received PY - 2021/03/19/accepted PY - 2021/4/26/entrez PY - 2021/4/27/pubmed PY - 2021/7/6/medline KW - Gardnerella vaginalis KW - Lactobacillus KW - bacterial vaginosis KW - female health KW - vaginal microbiome SP - 631972 EP - 631972 JF - Frontiers in cellular and infection microbiology JO - Front Cell Infect Microbiol VL - 11 N2 - The vaginal microbiome is an intricate and dynamic microecosystem that constantly undergoes fluctuations during the female menstrual cycle and the woman's entire life. A healthy vaginal microbiome is dominated by Lactobacillus which produce various antimicrobial compounds. Bacterial vaginosis (BV) is characterized by the loss or sharp decline in the total number of Lactobacillus and a corresponding marked increase in the concentration of anaerobic microbes. BV is a highly prevalent disorder of the vaginal microbiota among women of reproductive age globally. BV is confirmed to be associated with adverse gynecologic and obstetric outcomes, such as sexually transmitted infections, pelvic inflammatory disease, and preterm birth. Gardnerella vaginalis is the most common microorganism identified from BV. It is the predominant microbe in polymicrobial biofilms that could shelter G. vaginalis and other BV-associated microbes from adverse host environments. Many efforts have been made to increase our understanding of the vaginal microbiome in health and BV. Thus, improved novel and accurate diagnosis and therapeutic strategies for BV have been developed. This review covers the features of vaginal microbiome, BV, BV-associated diseases, and various strategies of diagnosis and treatment of BV, with an emphasis on recent research progresses. SN - 2235-2988 UR - https://www.unboundmedicine.com/medline/citation/33898328/The_Female_Vaginal_Microbiome_in_Health_and_Bacterial_Vaginosis_ DB - PRIME DP - Unbound Medicine ER -