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Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease.
Antioxid Redox Signal. 2021 06 01; 34(16):1319-1354.AR

Abstract

Reactive oxygen species (ROS; e.g., superoxide [O2•-] and hydrogen peroxide [H2O2]) and reactive nitrogen species (RNS; e.g., nitric oxide [NO•]) at the physiological level function as signaling molecules that mediate many biological responses, including cell proliferation, migration, differentiation, and gene expression. By contrast, excess ROS/RNS, a consequence of dysregulated redox homeostasis, is a hallmark of cardiovascular disease. Accumulating evidence suggests that both ROS and RNS regulate various metabolic pathways and enzymes. Recent studies indicate that cells have mechanisms that fine-tune ROS/RNS levels by tight regulation of metabolic pathways, such as glycolysis and oxidative phosphorylation. The ROS/RNS-mediated inhibition of glycolytic pathways promotes metabolic reprogramming away from glycolytic flux toward the oxidative pentose phosphate pathway to generate nicotinamide adenine dinucleotide phosphate (NADPH) for antioxidant defense. This review summarizes our current knowledge of the mechanisms by which ROS/RNS regulate metabolic enzymes and cellular metabolism and how cellular metabolism influences redox homeostasis and the pathogenesis of disease. A full understanding of these mechanisms will be important for the development of new therapeutic strategies to treat diseases associated with dysregulated redox homeostasis and metabolism. Antioxid. Redox Signal. 34, 1319-1354.

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Authors+Show Affiliations

Ushio-Fukai M
Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA. Department of Medicine (Cardiology) and Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Ash D
Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA. Department of Medicine (Cardiology) and Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Nagarkoti S
Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA. Department of Medicine (Cardiology) and Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Belin de Chantemèle EJ
Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA. Department of Medicine (Cardiology) and Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Fulton DJR
Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA. Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Fukai T
Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA. Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA. Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia, USA.

MeSH

Cardiovascular DiseasesHomeostasisHumansMetabolic Networks and PathwaysNADPReactive Nitrogen SpeciesReactive Oxygen SpeciesSignal Transduction

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

33899493

Citation

Ushio-Fukai, Masuko, et al. "Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease." Antioxidants & Redox Signaling, vol. 34, no. 16, 2021, pp. 1319-1354.
Ushio-Fukai M, Ash D, Nagarkoti S, et al. Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease. Antioxid Redox Signal. 2021;34(16):1319-1354.
Ushio-Fukai, M., Ash, D., Nagarkoti, S., Belin de Chantemèle, E. J., Fulton, D. J. R., & Fukai, T. (2021). Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease. Antioxidants & Redox Signaling, 34(16), 1319-1354. https://doi.org/10.1089/ars.2020.8161
Ushio-Fukai M, et al. Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease. Antioxid Redox Signal. 2021 06 1;34(16):1319-1354. PubMed PMID: 33899493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease. AU - Ushio-Fukai,Masuko, AU - Ash,Dipankar, AU - Nagarkoti,Sheela, AU - Belin de Chantemèle,Eric J, AU - Fulton,David J R, AU - Fukai,Tohru, PY - 2021/4/27/pubmed PY - 2022/1/4/medline PY - 2021/4/26/entrez KW - metabolism KW - oxidative stress KW - reactive nitrogen species KW - reactive oxygen species KW - redox signaling SP - 1319 EP - 1354 JF - Antioxidants & redox signaling JO - Antioxid Redox Signal VL - 34 IS - 16 N2 - Reactive oxygen species (ROS; e.g., superoxide [O2•-] and hydrogen peroxide [H2O2]) and reactive nitrogen species (RNS; e.g., nitric oxide [NO•]) at the physiological level function as signaling molecules that mediate many biological responses, including cell proliferation, migration, differentiation, and gene expression. By contrast, excess ROS/RNS, a consequence of dysregulated redox homeostasis, is a hallmark of cardiovascular disease. Accumulating evidence suggests that both ROS and RNS regulate various metabolic pathways and enzymes. Recent studies indicate that cells have mechanisms that fine-tune ROS/RNS levels by tight regulation of metabolic pathways, such as glycolysis and oxidative phosphorylation. The ROS/RNS-mediated inhibition of glycolytic pathways promotes metabolic reprogramming away from glycolytic flux toward the oxidative pentose phosphate pathway to generate nicotinamide adenine dinucleotide phosphate (NADPH) for antioxidant defense. This review summarizes our current knowledge of the mechanisms by which ROS/RNS regulate metabolic enzymes and cellular metabolism and how cellular metabolism influences redox homeostasis and the pathogenesis of disease. A full understanding of these mechanisms will be important for the development of new therapeutic strategies to treat diseases associated with dysregulated redox homeostasis and metabolism. Antioxid. Redox Signal. 34, 1319-1354. SN - 1557-7716 UR - https://www.unboundmedicine.com/medline/citation/33899493/Interplay_Between_Reactive_Oxygen/Reactive_Nitrogen_Species_and_Metabolism_in_Vascular_Biology_and_Disease_ DB - PRIME DP - Unbound Medicine ER -