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Editorial: SARS-CoV-2 mRNA Vaccines and the Possible Mechanism of Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT).
Med Sci Monit. 2021 Apr 26; 27:e932899.MS

Abstract

During 2020 and 2021, the global pandemic of coronavirus disease 2019 (COVID-19) due to severe acute respi- ratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in high death rates and acute and chronic morbidity in all countries. The rapid development of new mRNA vaccines to SARS-CoV-2 brings hope that the spread of this virus can be controlled. The ChAdOx1 nCoV-19 vaccine developed by a collaboration between the University of Oxford and AstraZeneca showed efficacy in clinical trials, with a good safety profile. However, there have been recent reports of the rare development of thrombotic events in young women following vaccination with ChAdOx1 nCoV-19, particularly of the rare condition of cavernous sinus thrombosis. Studies have begun to in- vestigate whether antibodies to the SARS-CoV-2 spike cross-react with platelet factor 4 (PF4/CXLC4) and mim- ic autoimmune heparin-induced thrombocytopenia. This Medical Science Monitor Editorial aims to briefly update the current status of studies on a possible rare complication of using new mRNA vaccines to prevent COVID-19.

Authors+Show Affiliations

Science Editor, International Scientific Information, Cambridge, United Kingdom.

Pub Type(s)

Editorial

Language

eng

PubMed ID

33900279

Citation

Parums, Dinah V.. "Editorial: SARS-CoV-2 mRNA Vaccines and the Possible Mechanism of Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT)." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 27, 2021, pp. e932899.
Parums DV. Editorial: SARS-CoV-2 mRNA Vaccines and the Possible Mechanism of Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT). Med Sci Monit. 2021;27:e932899.
Parums, D. V. (2021). Editorial: SARS-CoV-2 mRNA Vaccines and the Possible Mechanism of Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT). Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 27, e932899. https://doi.org/10.12659/MSM.932899
Parums DV. Editorial: SARS-CoV-2 mRNA Vaccines and the Possible Mechanism of Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT). Med Sci Monit. 2021 Apr 26;27:e932899. PubMed PMID: 33900279.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Editorial: SARS-CoV-2 mRNA Vaccines and the Possible Mechanism of Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT). A1 - Parums,Dinah V, Y1 - 2021/04/26/ PY - 2021/4/26/entrez PY - 2021/4/27/pubmed PY - 2021/5/27/medline SP - e932899 EP - e932899 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med Sci Monit VL - 27 N2 - During 2020 and 2021, the global pandemic of coronavirus disease 2019 (COVID-19) due to severe acute respi- ratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in high death rates and acute and chronic morbidity in all countries. The rapid development of new mRNA vaccines to SARS-CoV-2 brings hope that the spread of this virus can be controlled. The ChAdOx1 nCoV-19 vaccine developed by a collaboration between the University of Oxford and AstraZeneca showed efficacy in clinical trials, with a good safety profile. However, there have been recent reports of the rare development of thrombotic events in young women following vaccination with ChAdOx1 nCoV-19, particularly of the rare condition of cavernous sinus thrombosis. Studies have begun to in- vestigate whether antibodies to the SARS-CoV-2 spike cross-react with platelet factor 4 (PF4/CXLC4) and mim- ic autoimmune heparin-induced thrombocytopenia. This Medical Science Monitor Editorial aims to briefly update the current status of studies on a possible rare complication of using new mRNA vaccines to prevent COVID-19. SN - 1643-3750 UR - https://www.unboundmedicine.com/medline/citation/33900279/Editorial:_SARS_CoV_2_mRNA_Vaccines_and_the_Possible_Mechanism_of_Vaccine_Induced_Immune_Thrombotic_Thrombocytopenia__VITT__ DB - PRIME DP - Unbound Medicine ER -