Tags

Type your tag names separated by a space and hit enter

SARS-COV-2 infection in pregnant women and newborns in a Spanish cohort (GESNEO-COVID) during the first wave.
BMC Pregnancy Childbirth. 2021 Apr 26; 21(1):326.BP

Abstract

BACKGROUND

Knowledge about SARS-CoV-2 infection in pregnancy and newborns is scarce. The objective of this study is to analyse clinical and epidemiological characteristics of a cohort of women infected with SARS-CoV-2 during pregnancy and their newborns exposed to SARS-CoV-2 during gestation.

METHODS

Multicentric observational study of Spanish hospitals from the GESNEO-COVD cohort, participants in RECLIP (Spanish Network of Paediatric Clinical Assays). Women with confirmed SARS-CoV-2 infection by PCR and/or serology during pregnancy, diagnosed and delivering during the period 15/03/2020-31/07/2020 were included. Epidemiological, clinical, and analytical data was collected.

RESULTS

A total of 105 pregnant women with a median of 34.1 years old (IQR: 28.8-37.1) and 107 newborns were included. Globally, almost 65% of pregnant women had some COVID-19 symptoms and more than 43% were treated for SARS-COV-2. Overall, 30.8% of pregnant women had pneumonia and 5 (4.8%) women were admitted to the intensive care unit needing invasive mechanical ventilation. There was a rate of 36.2% of caesarean sections, which was associated with pneumonia during pregnancy (OR: 4.203, CI 95%: 1.473-11.995) and lower gestational age at delivery (OR: 0.724, CI 95%: 0.578-0.906). The prevalence of preterm birth was 20.6% and prematurity was associated with pneumonia during gestation (OR: 6.970, CI95%: 2.340-22.750) and having a positive SARS-CoV-2 PCR at delivery (OR: 6.520, CI95%: 1.840-31.790). All nasopharyngeal PCR in newborns were negative at birth and one positivized at 15 days of life. Two newborns died, one due to causes related to prematurity and another of unexpected sudden death during early skin-to-skin contact after delivery.

CONCLUSIONS

Although vertical transmission has not been reported in this cohort, the prognosis of newborns could be worsened by SARS-CoV-2 infection during pregnancy as COVID-19 pneumonia increased the risk of caesarean section deliveries and preterm births.

Authors+Show Affiliations

Paediatric Infectious Disease Unit, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain. itziiaarcg@gmail.com. Facultad de Medicina Universidad Complutense de Madrid, Madrid, Spain. itziiaarcg@gmail.com.Department of Obstetrics and Gynecology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.Department of Neonatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.Paediatric Infectious Disease Unit, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain. Facultad de Medicina Universidad Complutense de Madrid, Madrid, Spain. Department of Paediatric Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.Department of Obstetrics and Gynecology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.Department of Paediatric Gastroenterology Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.Department of Obstetrics and Gynecology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.Department of Paediatrics, Hospital Universitario HM Montepríncipe, Madrid, Spain.Department of Paediatrics, Hospital General de Albace, Castilla La Mancha, Spain.Department of Obstetrics and Gynecology, Complejo Hospitalario de Navarra, Navarra, Spain.Department of Neonatology, Hospital Universitario Infanta Sofía, Madrid, Spain.Department of Paediatrics, Hospital Universitario Infanta Leonor, Madrid, Spain.Department of Paediatrics, Hospital San Pedro de Alcántara, Cáceres, Spain.Paediatric Infectious Diseases Unit, Fundación para la Investigación Biomédica del Hospital 12 de Octubre, Madrid, Spain.Paediatric Infectious Disease Unit, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain. Facultad de Medicina Universidad Complutense de Madrid, Madrid, Spain. Department of Paediatric Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.Facultad de Medicina Universidad Complutense de Madrid, Madrid, Spain. Department of Obstetrics and Gynecology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.Facultad de Medicina Universidad Complutense de Madrid, Madrid, Spain. Department of Neonatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.Paediatric Infectious Disease Unit, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain. Facultad de Medicina Universidad Complutense de Madrid, Madrid, Spain. Department of Paediatric Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

33902483

Citation

Carrasco, Itzíar, et al. "SARS-COV-2 Infection in Pregnant Women and Newborns in a Spanish Cohort (GESNEO-COVID) During the First Wave." BMC Pregnancy and Childbirth, vol. 21, no. 1, 2021, p. 326.
Carrasco I, Muñoz-Chapuli M, Vigil-Vázquez S, et al. SARS-COV-2 infection in pregnant women and newborns in a Spanish cohort (GESNEO-COVID) during the first wave. BMC Pregnancy Childbirth. 2021;21(1):326.
Carrasco, I., Muñoz-Chapuli, M., Vigil-Vázquez, S., Aguilera-Alonso, D., Hernández, C., Sánchez-Sánchez, C., Oliver, C., Riaza, M., Pareja, M., Sanz, O., Pérez-Seoane, B., López, J., Márquez, E., Domínguez-Rodríguez, S., Hernanz-Lobo, A., De León-Luis, J. A., Sánchez-Luna, M., & Navarro, M. L. (2021). SARS-COV-2 infection in pregnant women and newborns in a Spanish cohort (GESNEO-COVID) during the first wave. BMC Pregnancy and Childbirth, 21(1), 326. https://doi.org/10.1186/s12884-021-03784-8
Carrasco I, et al. SARS-COV-2 Infection in Pregnant Women and Newborns in a Spanish Cohort (GESNEO-COVID) During the First Wave. BMC Pregnancy Childbirth. 2021 Apr 26;21(1):326. PubMed PMID: 33902483.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SARS-COV-2 infection in pregnant women and newborns in a Spanish cohort (GESNEO-COVID) during the first wave. AU - Carrasco,Itzíar, AU - Muñoz-Chapuli,Mar, AU - Vigil-Vázquez,Sara, AU - Aguilera-Alonso,David, AU - Hernández,Concepción, AU - Sánchez-Sánchez,César, AU - Oliver,Cristina, AU - Riaza,Mónica, AU - Pareja,Marta, AU - Sanz,Olga, AU - Pérez-Seoane,Beatriz, AU - López,Juan, AU - Márquez,Elena, AU - Domínguez-Rodríguez,Sara, AU - Hernanz-Lobo,Alicia, AU - De León-Luis,Juan Antonio, AU - Sánchez-Luna,Manuel, AU - Navarro,María Luisa, Y1 - 2021/04/26/ PY - 2020/11/26/received PY - 2021/03/22/accepted PY - 2021/4/27/entrez PY - 2021/4/28/pubmed PY - 2021/5/1/medline KW - COVID-19 KW - Caesarean section KW - Morbidity KW - Mortality KW - Newborn KW - Pneumonia KW - Pregnancy KW - Preterm birth KW - SARS-CoV-2 SP - 326 EP - 326 JF - BMC pregnancy and childbirth JO - BMC Pregnancy Childbirth VL - 21 IS - 1 N2 - BACKGROUND: Knowledge about SARS-CoV-2 infection in pregnancy and newborns is scarce. The objective of this study is to analyse clinical and epidemiological characteristics of a cohort of women infected with SARS-CoV-2 during pregnancy and their newborns exposed to SARS-CoV-2 during gestation. METHODS: Multicentric observational study of Spanish hospitals from the GESNEO-COVD cohort, participants in RECLIP (Spanish Network of Paediatric Clinical Assays). Women with confirmed SARS-CoV-2 infection by PCR and/or serology during pregnancy, diagnosed and delivering during the period 15/03/2020-31/07/2020 were included. Epidemiological, clinical, and analytical data was collected. RESULTS: A total of 105 pregnant women with a median of 34.1 years old (IQR: 28.8-37.1) and 107 newborns were included. Globally, almost 65% of pregnant women had some COVID-19 symptoms and more than 43% were treated for SARS-COV-2. Overall, 30.8% of pregnant women had pneumonia and 5 (4.8%) women were admitted to the intensive care unit needing invasive mechanical ventilation. There was a rate of 36.2% of caesarean sections, which was associated with pneumonia during pregnancy (OR: 4.203, CI 95%: 1.473-11.995) and lower gestational age at delivery (OR: 0.724, CI 95%: 0.578-0.906). The prevalence of preterm birth was 20.6% and prematurity was associated with pneumonia during gestation (OR: 6.970, CI95%: 2.340-22.750) and having a positive SARS-CoV-2 PCR at delivery (OR: 6.520, CI95%: 1.840-31.790). All nasopharyngeal PCR in newborns were negative at birth and one positivized at 15 days of life. Two newborns died, one due to causes related to prematurity and another of unexpected sudden death during early skin-to-skin contact after delivery. CONCLUSIONS: Although vertical transmission has not been reported in this cohort, the prognosis of newborns could be worsened by SARS-CoV-2 infection during pregnancy as COVID-19 pneumonia increased the risk of caesarean section deliveries and preterm births. SN - 1471-2393 UR - https://www.unboundmedicine.com/medline/citation/33902483/SARS_COV_2_infection_in_pregnant_women_and_newborns_in_a_Spanish_cohort__GESNEO_COVID__during_the_first_wave_ L2 - https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-021-03784-8 DB - PRIME DP - Unbound Medicine ER -