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Effects of caffeine on plasma renin activity, catecholamines and blood pressure.
N Engl J Med. 1978 Jan 26; 298(4):181-6.NEJM

Abstract

Using a double-blind, randomized, cross-over protocol, we studied the effect of a single dose of oral caffeine on plasma renin activity, catecholamines and cardiovascular control in nine healthy, young, non-coffee drinkers maintained in sodium balance throughout the study period. Caffeine (250 mg) or placebo was administered in a methylxanthine-free beverage to overnight-fasted supine subjects who had had no coffee, tea or cola in the previous three weeks. Caffeine increased plasma renin activity by 57 per cent, plasma norepinephrine by 75 per cent and plasma epinephrine by 207 per cent. Urinary normetanephrine and metanephrine were increased 52 per cent and 100 per cent respectively. Mean blood pressure rose 14/10 mm Hg one hour after caffeine ingestion. There was a slight fall and then a rise in heart rate. Plasma caffeine levels were usually maximal one hour after ingestion but there was considerable individual variation. A 20 per cent increase in respiratory rate correlated well with plasma caffeine levels. Under the conditions of study caffeine was a potent stimulator of plasma renin activity and adrenomedullary secretion. Whether habitual ingestion has similar effects remains to be determined.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

339084

Citation

Robertson, D, et al. "Effects of Caffeine On Plasma Renin Activity, Catecholamines and Blood Pressure." The New England Journal of Medicine, vol. 298, no. 4, 1978, pp. 181-6.
Robertson D, Frölich JC, Carr RK, et al. Effects of caffeine on plasma renin activity, catecholamines and blood pressure. N Engl J Med. 1978;298(4):181-6.
Robertson, D., Frölich, J. C., Carr, R. K., Watson, J. T., Hollifield, J. W., Shand, D. G., & Oates, J. A. (1978). Effects of caffeine on plasma renin activity, catecholamines and blood pressure. The New England Journal of Medicine, 298(4), 181-6.
Robertson D, et al. Effects of Caffeine On Plasma Renin Activity, Catecholamines and Blood Pressure. N Engl J Med. 1978 Jan 26;298(4):181-6. PubMed PMID: 339084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of caffeine on plasma renin activity, catecholamines and blood pressure. AU - Robertson,D, AU - Frölich,J C, AU - Carr,R K, AU - Watson,J T, AU - Hollifield,J W, AU - Shand,D G, AU - Oates,J A, PY - 1978/1/26/pubmed PY - 1978/1/26/medline PY - 1978/1/26/entrez SP - 181 EP - 6 JF - The New England journal of medicine JO - N Engl J Med VL - 298 IS - 4 N2 - Using a double-blind, randomized, cross-over protocol, we studied the effect of a single dose of oral caffeine on plasma renin activity, catecholamines and cardiovascular control in nine healthy, young, non-coffee drinkers maintained in sodium balance throughout the study period. Caffeine (250 mg) or placebo was administered in a methylxanthine-free beverage to overnight-fasted supine subjects who had had no coffee, tea or cola in the previous three weeks. Caffeine increased plasma renin activity by 57 per cent, plasma norepinephrine by 75 per cent and plasma epinephrine by 207 per cent. Urinary normetanephrine and metanephrine were increased 52 per cent and 100 per cent respectively. Mean blood pressure rose 14/10 mm Hg one hour after caffeine ingestion. There was a slight fall and then a rise in heart rate. Plasma caffeine levels were usually maximal one hour after ingestion but there was considerable individual variation. A 20 per cent increase in respiratory rate correlated well with plasma caffeine levels. Under the conditions of study caffeine was a potent stimulator of plasma renin activity and adrenomedullary secretion. Whether habitual ingestion has similar effects remains to be determined. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/339084/Effects_of_caffeine_on_plasma_renin_activity_catecholamines_and_blood_pressure_ L2 - https://www.nejm.org/doi/10.1056/NEJM197801262980403?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -