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Minocycline and Its Impact on Microbial Dysbiosis in the Skin and Gastrointestinal Tract of Acne Patients.
Ann Dermatol. 2020 Feb; 32(1):21-30.AD

Abstract

BACKGROUND

Associations between acne and gastrointestinal comorbidities suggest that microbial dysbiosis and intestinal permeability may promote inflammatory acne, a condition often managed with oral antibiotics.

OBJECTIVE

We performed a case-control study to investigate the skin and gut microbiota in 8 acne patients before and after receiving oral minocycline compared to controls matched by age ±5 years, sex, and race.

METHODS

DNA was extracted from stool samples and facial skin swabs. Sequencing of the V3V4 region of the bacterial 16S rRNA gene was performed using Illumina MiSeq and analyzed using QIIME/MetaStats 2.0 software.

RESULTS

Acne patients included 7 female and 1 male, ages 20~32. Shannon diversity was not significantly different between the skin (p=0.153) or gut (p<0.999) microbiota of acne patients before and after antibiotics. The gut microbiota in pre-antibiotic acne patients compared to acne-free controls was depleted in probiotics Lactobacillus iners (p=0.001), Lactobacillus zeae (p=0.001), and Bifidobacterium animalis (p=0.026). After antibiotics, the gut microbiota of acne patients was depleted in Lactobacillus salivarius (p=0.001), Bifidobacterium adolescentis (p=0.002), Bifidobacterium pseudolongum (p=0.010), and Bifidobacterium breve (p=0.042), while the skin microbiota was enriched in probiotics Bifidobacterium longum (p=0.028) and Leuconostoc mesenteroides (p=0.029) and depleted in Staphylococcus epidermidis (p=0.009) and Prevotella nigrescens (p=0.028). At the phylum level, significant enrichment of Bacteroidetes in stool of acne patients following antibiotic treatment (p=0.033) led to a decreased Firmicutes to Bacteroidetes ratio.

CONCLUSION

Minocycline produces significant derangements in the microbiota of the skin and gut, including many probiotic species, highlighting the potential for more targeted antimicrobial treatments for acne.

Authors+Show Affiliations

Department of Dermatology, Johns Hopkins University, Baltimore, MD, USA.Department of Dermatology, Johns Hopkins University, Baltimore, MD, USA. Department of Dermatology, Medical University of Graz, Graz, Austria.Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.Institute for Genome Sciences, University of Maryland, Baltimore, MD, USA.Department of Dermatology, Johns Hopkins University, Baltimore, MD, USA.Department of Dermatology, Johns Hopkins University, Baltimore, MD, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33911705

Citation

Thompson, Katherine G., et al. "Minocycline and Its Impact On Microbial Dysbiosis in the Skin and Gastrointestinal Tract of Acne Patients." Annals of Dermatology, vol. 32, no. 1, 2020, pp. 21-30.
Thompson KG, Rainer BM, Antonescu C, et al. Minocycline and Its Impact on Microbial Dysbiosis in the Skin and Gastrointestinal Tract of Acne Patients. Ann Dermatol. 2020;32(1):21-30.
Thompson, K. G., Rainer, B. M., Antonescu, C., Florea, L., Mongodin, E. F., Kang, S., & Chien, A. L. (2020). Minocycline and Its Impact on Microbial Dysbiosis in the Skin and Gastrointestinal Tract of Acne Patients. Annals of Dermatology, 32(1), 21-30. https://doi.org/10.5021/ad.2020.32.1.21
Thompson KG, et al. Minocycline and Its Impact On Microbial Dysbiosis in the Skin and Gastrointestinal Tract of Acne Patients. Ann Dermatol. 2020;32(1):21-30. PubMed PMID: 33911705.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Minocycline and Its Impact on Microbial Dysbiosis in the Skin and Gastrointestinal Tract of Acne Patients. AU - Thompson,Katherine G, AU - Rainer,Barbara M, AU - Antonescu,Corina, AU - Florea,Liliana, AU - Mongodin,Emmanuel F, AU - Kang,Sewon, AU - Chien,Anna L, Y1 - 2020/01/09/ PY - 2019/08/19/received PY - 2019/10/04/revised PY - 2019/10/15/accepted PY - 2021/4/29/entrez PY - 2020/2/1/pubmed PY - 2020/2/1/medline KW - Acne vulgaris KW - Bacteroidetes KW - Firmicutes KW - Microbiome KW - Minocycline KW - Propionibacterium SP - 21 EP - 30 JF - Annals of dermatology JO - Ann Dermatol VL - 32 IS - 1 N2 - BACKGROUND: Associations between acne and gastrointestinal comorbidities suggest that microbial dysbiosis and intestinal permeability may promote inflammatory acne, a condition often managed with oral antibiotics. OBJECTIVE: We performed a case-control study to investigate the skin and gut microbiota in 8 acne patients before and after receiving oral minocycline compared to controls matched by age ±5 years, sex, and race. METHODS: DNA was extracted from stool samples and facial skin swabs. Sequencing of the V3V4 region of the bacterial 16S rRNA gene was performed using Illumina MiSeq and analyzed using QIIME/MetaStats 2.0 software. RESULTS: Acne patients included 7 female and 1 male, ages 20~32. Shannon diversity was not significantly different between the skin (p=0.153) or gut (p<0.999) microbiota of acne patients before and after antibiotics. The gut microbiota in pre-antibiotic acne patients compared to acne-free controls was depleted in probiotics Lactobacillus iners (p=0.001), Lactobacillus zeae (p=0.001), and Bifidobacterium animalis (p=0.026). After antibiotics, the gut microbiota of acne patients was depleted in Lactobacillus salivarius (p=0.001), Bifidobacterium adolescentis (p=0.002), Bifidobacterium pseudolongum (p=0.010), and Bifidobacterium breve (p=0.042), while the skin microbiota was enriched in probiotics Bifidobacterium longum (p=0.028) and Leuconostoc mesenteroides (p=0.029) and depleted in Staphylococcus epidermidis (p=0.009) and Prevotella nigrescens (p=0.028). At the phylum level, significant enrichment of Bacteroidetes in stool of acne patients following antibiotic treatment (p=0.033) led to a decreased Firmicutes to Bacteroidetes ratio. CONCLUSION: Minocycline produces significant derangements in the microbiota of the skin and gut, including many probiotic species, highlighting the potential for more targeted antimicrobial treatments for acne. SN - 2005-3894 UR - https://www.unboundmedicine.com/medline/citation/33911705/Minocycline_and_Its_Impact_on_Microbial_Dysbiosis_in_the_Skin_and_Gastrointestinal_Tract_of_Acne_Patients_ L2 - https://anndermatol.org/DOIx.php?id=10.5021/ad.2020.32.1.21 DB - PRIME DP - Unbound Medicine ER -
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