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Antiangiogenic and Antioxidant In Vitro Properties of Hydroethanolic Extract from açaí (Euterpe oleracea) Dietary Powder Supplement.
Molecules. 2021 Apr 01; 26(7)M

Abstract

The Euterpe oleracea fruit (açaí) is a promising source of polyphenols with health-promoting properties. To our knowledge, few studies have focused on the influence of açaí phytochemicals on angiogenesis, with a significant impact on cancer. This study aimed at investigating the phytochemical profile of a purple açaí hydroethanolic extract (AHE) obtained from a commercial dietary powder supplement by high-performance liquid chromatography coupled to diode array detection and electrospray ionization mass spectrometry, and evaluate its in vitro effects on distinct angiogenic steps during vessel growth and on oxidative markers in human microvascular endothelial cells (HMEC-1). The phenolic profile of AHE revealed the presence of significant levels of anthocyanins, mainly cyanidin-3-O-rutinoside, and other flavonoids with promising health effects. The in vitro studies demonstrated that AHE exerts antiangiogenic activity with no cytotoxic effect. The AHE was able to decrease HMEC-1 migration and invasion potential, as well as to inhibit the formation of capillary-like structures. Additionally, AHE increased antioxidant defenses by upregulating superoxide dismutase and catalase enzymatic activities, accompanied by a reduction in the production of reactive oxygen species. These data bring new insights into the potential application of angiogenic inhibitors present in AHE on the development of novel therapeutic approaches for angiogenesis-dependent diseases.

Authors+Show Affiliations

i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal. Departamento de Biomedicina, Unidade de Bioquímica, Faculdade de Medicina, Universidade do Porto, 4200-319 Porto, Portugal.Departamento de Biomedicina, Unidade de Bioquímica, Faculdade de Medicina, Universidade do Porto, 4200-319 Porto, Portugal. REQUIMTE/LAQV, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre 687, 4169-007 Porto, Portugal.i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal. Faculdade de Ciências da Saúde, Universidade Fernando Pessoa, Praça 9 de Abril 349, 4249-004 Porto, Portugal.i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal. Departamento de Biomedicina, Unidade de Bioquímica, Faculdade de Medicina, Universidade do Porto, 4200-319 Porto, Portugal.REQUIMTE/LAQV, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre 687, 4169-007 Porto, Portugal.REQUIMTE/LAQV, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre 687, 4169-007 Porto, Portugal.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33916166

Citation

Costa, Raquel, et al. "Antiangiogenic and Antioxidant in Vitro Properties of Hydroethanolic Extract From Açaí (Euterpe Oleracea) Dietary Powder Supplement." Molecules (Basel, Switzerland), vol. 26, no. 7, 2021.
Costa R, Azevedo D, Barata P, et al. Antiangiogenic and Antioxidant In Vitro Properties of Hydroethanolic Extract from açaí (Euterpe oleracea) Dietary Powder Supplement. Molecules. 2021;26(7).
Costa, R., Azevedo, D., Barata, P., Soares, R., Guido, L. F., & Carvalho, D. O. (2021). Antiangiogenic and Antioxidant In Vitro Properties of Hydroethanolic Extract from açaí (Euterpe oleracea) Dietary Powder Supplement. Molecules (Basel, Switzerland), 26(7). https://doi.org/10.3390/molecules26072011
Costa R, et al. Antiangiogenic and Antioxidant in Vitro Properties of Hydroethanolic Extract From Açaí (Euterpe Oleracea) Dietary Powder Supplement. Molecules. 2021 Apr 1;26(7) PubMed PMID: 33916166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiangiogenic and Antioxidant In Vitro Properties of Hydroethanolic Extract from açaí (Euterpe oleracea) Dietary Powder Supplement. AU - Costa,Raquel, AU - Azevedo,Daniela, AU - Barata,Pedro, AU - Soares,Raquel, AU - Guido,Luís F, AU - Carvalho,Daniel O, Y1 - 2021/04/01/ PY - 2021/03/15/received PY - 2021/03/27/revised PY - 2021/03/29/accepted PY - 2021/4/30/entrez PY - 2021/5/1/pubmed PY - 2021/5/25/medline KW - Euterpe oleracea KW - angiogenesis HPLC-DAD-ESI-MSn KW - anthocyanins KW - antioxidants KW - açaí KW - phenolic compounds JF - Molecules (Basel, Switzerland) JO - Molecules VL - 26 IS - 7 N2 - The Euterpe oleracea fruit (açaí) is a promising source of polyphenols with health-promoting properties. To our knowledge, few studies have focused on the influence of açaí phytochemicals on angiogenesis, with a significant impact on cancer. This study aimed at investigating the phytochemical profile of a purple açaí hydroethanolic extract (AHE) obtained from a commercial dietary powder supplement by high-performance liquid chromatography coupled to diode array detection and electrospray ionization mass spectrometry, and evaluate its in vitro effects on distinct angiogenic steps during vessel growth and on oxidative markers in human microvascular endothelial cells (HMEC-1). The phenolic profile of AHE revealed the presence of significant levels of anthocyanins, mainly cyanidin-3-O-rutinoside, and other flavonoids with promising health effects. The in vitro studies demonstrated that AHE exerts antiangiogenic activity with no cytotoxic effect. The AHE was able to decrease HMEC-1 migration and invasion potential, as well as to inhibit the formation of capillary-like structures. Additionally, AHE increased antioxidant defenses by upregulating superoxide dismutase and catalase enzymatic activities, accompanied by a reduction in the production of reactive oxygen species. These data bring new insights into the potential application of angiogenic inhibitors present in AHE on the development of novel therapeutic approaches for angiogenesis-dependent diseases. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/33916166/Antiangiogenic_and_Antioxidant_In_Vitro_Properties_of_Hydroethanolic_Extract_from_açaí__Euterpe_oleracea__Dietary_Powder_Supplement_ L2 - https://www.mdpi.com/resolver?pii=molecules26072011 DB - PRIME DP - Unbound Medicine ER -