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Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action.
Int J Mol Sci. 2021 Apr 21; 22(9)IJ

Abstract

As the major nonpsychotropic constituent of Cannabis sativa, cannabidiol (CBD) is regarded as one of the most promising therapeutic agents due to its proven effectiveness in clinical trials for many human diseases. Due to the urgent need for more efficient pharmacological treatments for several chronic diseases, in this review, we discuss the potential beneficial effects of CBD for Alzheimer's disease, epilepsy, multiple sclerosis, and neurological cancers. Due to its wide range of pharmacological activities (e.g., antioxidant, anti-inflammatory, and neuroprotective properties), CBD is considered a multimodal drug for the treatment of a range of neurodegenerative disorders, and various cancer types, including neoplasms of the neural system. The different mechanisms of action of CBD are here disclosed, together with recent progress in the use of this cannabis-derived constituent as a new therapeutic approach.

Authors+Show Affiliations

Department of Biotechnology, Institute of Natural Fibres and Medicinal Plants-State Research Institute, Wojska Polskiego 71B, 60-630 Poznań, Poland.Chair and Department of Medical Microbiology, Poznań University of Medical Sciences, Wieniawskiego 3, 61-712 Poznań, Poland.Institute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, Poland. Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal. CEB-Center of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.Department of Biotechnology, Institute of Natural Fibres and Medicinal Plants-State Research Institute, Wojska Polskiego 71B, 60-630 Poznań, Poland.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33919010

Citation

Ożarowski, Marcin, et al. "Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments On the Molecular Mechanism of Action." International Journal of Molecular Sciences, vol. 22, no. 9, 2021.
Ożarowski M, Karpiński TM, Zielińska A, et al. Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action. Int J Mol Sci. 2021;22(9).
Ożarowski, M., Karpiński, T. M., Zielińska, A., Souto, E. B., & Wielgus, K. (2021). Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action. International Journal of Molecular Sciences, 22(9). https://doi.org/10.3390/ijms22094294
Ożarowski M, et al. Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments On the Molecular Mechanism of Action. Int J Mol Sci. 2021 Apr 21;22(9) PubMed PMID: 33919010.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action. AU - Ożarowski,Marcin, AU - Karpiński,Tomasz M, AU - Zielińska,Aleksandra, AU - Souto,Eliana B, AU - Wielgus,Karolina, Y1 - 2021/04/21/ PY - 2021/03/24/received PY - 2021/04/17/revised PY - 2021/04/19/accepted PY - 2021/4/30/entrez PY - 2021/5/1/pubmed PY - 2021/5/14/medline KW - Alzheimer’s disease KW - CBD KW - Cannabis sativa KW - cancer KW - cannabidiol KW - epilepsy KW - mechanism of action KW - multiple sclerosis KW - pharmacological activity JF - International journal of molecular sciences JO - Int J Mol Sci VL - 22 IS - 9 N2 - As the major nonpsychotropic constituent of Cannabis sativa, cannabidiol (CBD) is regarded as one of the most promising therapeutic agents due to its proven effectiveness in clinical trials for many human diseases. Due to the urgent need for more efficient pharmacological treatments for several chronic diseases, in this review, we discuss the potential beneficial effects of CBD for Alzheimer's disease, epilepsy, multiple sclerosis, and neurological cancers. Due to its wide range of pharmacological activities (e.g., antioxidant, anti-inflammatory, and neuroprotective properties), CBD is considered a multimodal drug for the treatment of a range of neurodegenerative disorders, and various cancer types, including neoplasms of the neural system. The different mechanisms of action of CBD are here disclosed, together with recent progress in the use of this cannabis-derived constituent as a new therapeutic approach. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/33919010/Cannabidiol_in_Neurological_and_Neoplastic_Diseases:_Latest_Developments_on_the_Molecular_Mechanism_of_Action_ L2 - https://www.mdpi.com/resolver?pii=ijms22094294 DB - PRIME DP - Unbound Medicine ER -