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Antioxidant and Antidiabetic Activity of Proanthocyanidins from Fagopyrum dibotrys.
Molecules. 2021 Apr 21; 26(9)M

Abstract

Proanthocyanidins are natural glycosidase inhibitors with excellent antioxidant activity. This study aims to search for a new source of proanthocyanidins for the prevention and treatment of type 2 diabetes with higher content and better activity and get their structure elucidated. First, the total proanthocyanidins contents (TOPCs), antioxidant activity, antidiabetic activity of seven common Polygonaceae plants were analyzed and compared. Then proanthocyanidins from the rhizome of Fagopyrum dibotrys were purified, and the detailed structure was comprehensively analyzed by ultraviolet visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FT-IR), 13C nuclear magnetic resonance spectroscopy (13C NMR), reversed-phase high-performance liquid chromatography-electrospray mass spectrometry (RP-HPLC-ESI-MS), and matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS). The rhizome of F. dibotrys showed the highest TOPCs, the strongest antioxidant, and antidiabetic activities; the TOPCs, antioxidant and antidiabetic activities were all very significantly positively correlated. Proanthocyanidins purified from the rhizome of F. dibotrys showed better antidiabetic activity than grape seed proanthocyanidins (GsPs). Seventy-two proanthocyanidins from trimer to undecamer with a mean degree of polymerization (mDP) of about 5.02 ± 0.21 were identified with catechin and epicatechin as the dominant monomers.

Conclusion:

Proanthocyanidins are the main antioxidant and antidiabetic active substances of F. dibotrys and are expected to be developed into potential antioxidant and hypoglycemic products.

Authors+Show Affiliations

College of Life Sciences, Northwest A & F University, Yangling 712100, China.College of Life Sciences, Northwest A & F University, Yangling 712100, China.Institute of Landscape, Taiyuan University, Taiyuan 030032, China.College of Life Sciences, Northwest A & F University, Yangling 712100, China.Zhejiang Provincial Key Laboratory of Plant Secondary Metabolism Regulation, College of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.College of Life Sciences, Northwest A & F University, Yangling 712100, China. Zhejiang Provincial Key Laboratory of Plant Secondary Metabolism Regulation, College of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33919259

Citation

Li, Xin, et al. "Antioxidant and Antidiabetic Activity of Proanthocyanidins From Fagopyrum Dibotrys." Molecules (Basel, Switzerland), vol. 26, no. 9, 2021.
Li X, Liu J, Chang Q, et al. Antioxidant and Antidiabetic Activity of Proanthocyanidins from Fagopyrum dibotrys. Molecules. 2021;26(9).
Li, X., Liu, J., Chang, Q., Zhou, Z., Han, R., & Liang, Z. (2021). Antioxidant and Antidiabetic Activity of Proanthocyanidins from Fagopyrum dibotrys. Molecules (Basel, Switzerland), 26(9). https://doi.org/10.3390/molecules26092417
Li X, et al. Antioxidant and Antidiabetic Activity of Proanthocyanidins From Fagopyrum Dibotrys. Molecules. 2021 Apr 21;26(9) PubMed PMID: 33919259.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant and Antidiabetic Activity of Proanthocyanidins from Fagopyrum dibotrys. AU - Li,Xin, AU - Liu,Jingling, AU - Chang,Qinxiang, AU - Zhou,Ziyun, AU - Han,Ruilian, AU - Liang,Zongsuo, Y1 - 2021/04/21/ PY - 2021/03/22/received PY - 2021/04/16/revised PY - 2021/04/19/accepted PY - 2021/4/30/entrez PY - 2021/5/1/pubmed PY - 2021/5/27/medline KW - Fagopyrum dibotrys KW - antidiabetes KW - antioxidant KW - proanthocyanidins KW - structural analysis JF - Molecules (Basel, Switzerland) JO - Molecules VL - 26 IS - 9 N2 - Proanthocyanidins are natural glycosidase inhibitors with excellent antioxidant activity. This study aims to search for a new source of proanthocyanidins for the prevention and treatment of type 2 diabetes with higher content and better activity and get their structure elucidated. First, the total proanthocyanidins contents (TOPCs), antioxidant activity, antidiabetic activity of seven common Polygonaceae plants were analyzed and compared. Then proanthocyanidins from the rhizome of Fagopyrum dibotrys were purified, and the detailed structure was comprehensively analyzed by ultraviolet visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FT-IR), 13C nuclear magnetic resonance spectroscopy (13C NMR), reversed-phase high-performance liquid chromatography-electrospray mass spectrometry (RP-HPLC-ESI-MS), and matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS). The rhizome of F. dibotrys showed the highest TOPCs, the strongest antioxidant, and antidiabetic activities; the TOPCs, antioxidant and antidiabetic activities were all very significantly positively correlated. Proanthocyanidins purified from the rhizome of F. dibotrys showed better antidiabetic activity than grape seed proanthocyanidins (GsPs). Seventy-two proanthocyanidins from trimer to undecamer with a mean degree of polymerization (mDP) of about 5.02 ± 0.21 were identified with catechin and epicatechin as the dominant monomers. Conclusion: Proanthocyanidins are the main antioxidant and antidiabetic active substances of F. dibotrys and are expected to be developed into potential antioxidant and hypoglycemic products. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/33919259/Antioxidant_and_Antidiabetic_Activity_of_Proanthocyanidins_from_Fagopyrum_dibotrys_ L2 - https://www.mdpi.com/resolver?pii=molecules26092417 DB - PRIME DP - Unbound Medicine ER -