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The Role of Macrophages in the Development of Acute and Chronic Inflammatory Lung Diseases.
Cells. 2021 04 14; 10(4)C

Abstract

Macrophages play an important role in the innate and adaptive immune responses of organ systems, including the lungs, to particles and pathogens. Cumulative results show that macrophages contribute to the development and progression of acute or chronic inflammatory responses through the secretion of inflammatory cytokines/chemokines and the activation of transcription factors in the pathogenesis of inflammatory lung diseases, such as acute lung injury (ALI), acute respiratory distress syndrome (ARDS), ARDS related to COVID-19 (coronavirus disease 2019, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)), allergic asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF). This review summarizes the functions of macrophages and their associated underlying mechanisms in the development of ALI, ARDS, COVID-19-related ARDS, allergic asthma, COPD, and IPF and briefly introduces the acute and chronic experimental animal models. Thus, this review suggests an effective therapeutic approach that focuses on the regulation of macrophage function in the context of inflammatory lung diseases.

Authors+Show Affiliations

Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk, Cheongju 28116, Korea.Department of Pharmacology, College of Medicine, Kangwon National University, Chuncheon 24341, Korea.Department of Pharmacology, College of Medicine, Kangwon National University, Chuncheon 24341, Korea.Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk, Cheongju 28116, Korea. College of Pharmacy, Chungbuk National University, Cheongju 28160, Korea.Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk, Cheongju 28116, Korea. College of Pharmacy, Chungnam National University, Daejeon 34134, Korea.Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk, Cheongju 28116, Korea. College of Pharmacy, Chungbuk National University, Cheongju 28160, Korea.Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk, Cheongju 28116, Korea.Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk, Cheongju 28116, Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

33919784

Citation

Lee, Jae-Won, et al. "The Role of Macrophages in the Development of Acute and Chronic Inflammatory Lung Diseases." Cells, vol. 10, no. 4, 2021.
Lee JW, Chun W, Lee HJ, et al. The Role of Macrophages in the Development of Acute and Chronic Inflammatory Lung Diseases. Cells. 2021;10(4).
Lee, J. W., Chun, W., Lee, H. J., Min, J. H., Kim, S. M., Seo, J. Y., Ahn, K. S., & Oh, S. R. (2021). The Role of Macrophages in the Development of Acute and Chronic Inflammatory Lung Diseases. Cells, 10(4). https://doi.org/10.3390/cells10040897
Lee JW, et al. The Role of Macrophages in the Development of Acute and Chronic Inflammatory Lung Diseases. Cells. 2021 04 14;10(4) PubMed PMID: 33919784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Role of Macrophages in the Development of Acute and Chronic Inflammatory Lung Diseases. AU - Lee,Jae-Won, AU - Chun,Wanjoo, AU - Lee,Hee Jae, AU - Min,Jae-Hong, AU - Kim,Seong-Man, AU - Seo,Ji-Yun, AU - Ahn,Kyung-Seop, AU - Oh,Sei-Ryang, Y1 - 2021/04/14/ PY - 2021/03/27/received PY - 2021/04/08/revised PY - 2021/04/13/accepted PY - 2021/4/30/entrez PY - 2021/5/1/pubmed PY - 2021/5/14/medline KW - M1/M2 polarization KW - acute/chronic inflammatory diseases KW - cytokines KW - macrophages JF - Cells JO - Cells VL - 10 IS - 4 N2 - Macrophages play an important role in the innate and adaptive immune responses of organ systems, including the lungs, to particles and pathogens. Cumulative results show that macrophages contribute to the development and progression of acute or chronic inflammatory responses through the secretion of inflammatory cytokines/chemokines and the activation of transcription factors in the pathogenesis of inflammatory lung diseases, such as acute lung injury (ALI), acute respiratory distress syndrome (ARDS), ARDS related to COVID-19 (coronavirus disease 2019, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)), allergic asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF). This review summarizes the functions of macrophages and their associated underlying mechanisms in the development of ALI, ARDS, COVID-19-related ARDS, allergic asthma, COPD, and IPF and briefly introduces the acute and chronic experimental animal models. Thus, this review suggests an effective therapeutic approach that focuses on the regulation of macrophage function in the context of inflammatory lung diseases. SN - 2073-4409 UR - https://www.unboundmedicine.com/medline/citation/33919784/The_Role_of_Macrophages_in_the_Development_of_Acute_and_Chronic_Inflammatory_Lung_Diseases_ L2 - https://www.mdpi.com/resolver?pii=cells10040897 DB - PRIME DP - Unbound Medicine ER -