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Neurovascular unit in diabetic retinopathy: pathophysiological roles and potential therapeutical targets.
Eye Vis (Lond). 2021 May 01; 8(1):15.EV

Abstract

Diabetic retinopathy (DR), one of the common complications of diabetes, is the leading cause of visual loss in working-age individuals in many industrialized countries. It has been traditionally regarded as a purely microvascular disease in the retina. However, an increasing number of studies have shown that DR is a complex neurovascular disorder that affects not only vascular structure but also neural tissue of the retina. Deterioration of neural retina could precede microvascular abnormalities in the DR, leading to microvascular changes. Furthermore, disruption of interactions among neurons, vascular cells, glia and local immune cells, which collectively form the neurovascular unit, is considered to be associated with the progression of DR early on in the disease. Therefore, it makes sense to develop new therapeutic strategies to prevent or reverse retinal neurodegeneration, neuroinflammation and impaired cell-cell interactions of the neurovascular unit in early stage DR. Here, we present current perspectives on the pathophysiology of DR as a neurovascular disease, especially at the early stage. Potential novel treatments for preventing or reversing neurovascular injuries in DR are discussed as well.

Authors+Show Affiliations

Department of Pathology, Xi'an Medical University, Xi'an, Shaanxi Province, China. shennian@xiyi.edu.cn.Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.Institute of Basic Medicine Science, Xi'an Medical University, Xi'an, Shaanxi Province, China.Department of Biochemistry and Molecular Biology, Xi'an Medical University, Xi'an, Shaanxi Province, China.Department of Ophthalmology, First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, Yunnan Province, China. fionayangdi@outlook.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33931128

Citation

Nian, Shen, et al. "Neurovascular Unit in Diabetic Retinopathy: Pathophysiological Roles and Potential Therapeutical Targets." Eye and Vision (London, England), vol. 8, no. 1, 2021, p. 15.
Nian S, Lo ACY, Mi Y, et al. Neurovascular unit in diabetic retinopathy: pathophysiological roles and potential therapeutical targets. Eye Vis (Lond). 2021;8(1):15.
Nian, S., Lo, A. C. Y., Mi, Y., Ren, K., & Yang, D. (2021). Neurovascular unit in diabetic retinopathy: pathophysiological roles and potential therapeutical targets. Eye and Vision (London, England), 8(1), 15. https://doi.org/10.1186/s40662-021-00239-1
Nian S, et al. Neurovascular Unit in Diabetic Retinopathy: Pathophysiological Roles and Potential Therapeutical Targets. Eye Vis (Lond). 2021 May 1;8(1):15. PubMed PMID: 33931128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurovascular unit in diabetic retinopathy: pathophysiological roles and potential therapeutical targets. AU - Nian,Shen, AU - Lo,Amy C Y, AU - Mi,Yajing, AU - Ren,Kai, AU - Yang,Di, Y1 - 2021/05/01/ PY - 2020/07/29/received PY - 2021/04/02/accepted PY - 2021/5/1/entrez PY - 2021/5/2/pubmed PY - 2021/5/2/medline KW - Diabetic retinopathy KW - Gliosis KW - Inflammation KW - Neurodegeneration KW - Neurovascular unit KW - treatment SP - 15 EP - 15 JF - Eye and vision (London, England) JO - Eye Vis (Lond) VL - 8 IS - 1 N2 - Diabetic retinopathy (DR), one of the common complications of diabetes, is the leading cause of visual loss in working-age individuals in many industrialized countries. It has been traditionally regarded as a purely microvascular disease in the retina. However, an increasing number of studies have shown that DR is a complex neurovascular disorder that affects not only vascular structure but also neural tissue of the retina. Deterioration of neural retina could precede microvascular abnormalities in the DR, leading to microvascular changes. Furthermore, disruption of interactions among neurons, vascular cells, glia and local immune cells, which collectively form the neurovascular unit, is considered to be associated with the progression of DR early on in the disease. Therefore, it makes sense to develop new therapeutic strategies to prevent or reverse retinal neurodegeneration, neuroinflammation and impaired cell-cell interactions of the neurovascular unit in early stage DR. Here, we present current perspectives on the pathophysiology of DR as a neurovascular disease, especially at the early stage. Potential novel treatments for preventing or reversing neurovascular injuries in DR are discussed as well. SN - 2326-0254 UR - https://www.unboundmedicine.com/medline/citation/33931128/Neurovascular_unit_in_diabetic_retinopathy:_pathophysiological_roles_and_potential_therapeutical_targets_ L2 - https://eandv.biomedcentral.com/articles/10.1186/s40662-021-00239-1 DB - PRIME DP - Unbound Medicine ER -
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