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A prospective study of moderate alcohol consumption and the risk of coronary disease and stroke in women.

Abstract

In 1980, 87,526 female nurses 34 to 59 years of age completed a dietary questionnaire that assessed their consumption of beer, wine, and liquor. By 1984, during 334,382 person-years of follow-up, we had documented 200 incident cases of severe coronary heart disease (164 nonfatal myocardial infarctions and 36 deaths due to coronary disease), 66 ischemic strokes, and 28 subarachnoid hemorrhages. Follow-up was 98 percent complete. As compared with nondrinkers, women who consumed 5 to 14 g of alcohol per day (three to nine drinks per week) had a relative risk of coronary disease of 0.6 (95 percent confidence interval, 0.4 to 0.9); for 15 to 24 g per day the relative risk was 0.6 (0.3 to 1.1), and for 25 g or more per day it was 0.4 (0.2 to 0.8), after adjustment for risk factors for coronary disease. Alcohol intake was also associated with a decreased risk of ischemic stroke. For 5 to 14 g of alcohol per day the relative risk was 0.3 (0.1 to 0.7), and for 15 g per day or more it was 0.5 (0.2 to 1.1). In contrast, although the number of cases of subarachnoid hemorrhage was small, alcohol intake tended to be associated with an increased risk of this disorder; for 5 to 14 g per day the relative risk was 3.7 (1.0 to 13.8). These prospective data suggest that among middle-aged women, moderate alcohol consumption decreases the risks of coronary heart disease and ischemic stroke but may increase the risk of subarachnoid hemorrhage.

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  • Authors+Show Affiliations

    ,

    Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, MA 02115.

    , , ,

    Source

    The New England journal of medicine 319:5 1988 Aug 04 pg 267-73

    MeSH

    Adult
    Alcohol Drinking
    Brain Ischemia
    Cerebrovascular Disorders
    Coronary Disease
    Female
    Follow-Up Studies
    Humans
    Middle Aged
    Myocardial Infarction
    Nutrition Surveys
    Prospective Studies
    Risk Factors
    Subarachnoid Hemorrhage
    Surveys and Questionnaires
    United States

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    3393181

    Citation

    Stampfer, M J., et al. "A Prospective Study of Moderate Alcohol Consumption and the Risk of Coronary Disease and Stroke in Women." The New England Journal of Medicine, vol. 319, no. 5, 1988, pp. 267-73.
    Stampfer MJ, Colditz GA, Willett WC, et al. A prospective study of moderate alcohol consumption and the risk of coronary disease and stroke in women. N Engl J Med. 1988;319(5):267-73.
    Stampfer, M. J., Colditz, G. A., Willett, W. C., Speizer, F. E., & Hennekens, C. H. (1988). A prospective study of moderate alcohol consumption and the risk of coronary disease and stroke in women. The New England Journal of Medicine, 319(5), pp. 267-73.
    Stampfer MJ, et al. A Prospective Study of Moderate Alcohol Consumption and the Risk of Coronary Disease and Stroke in Women. N Engl J Med. 1988 Aug 4;319(5):267-73. PubMed PMID: 3393181.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A prospective study of moderate alcohol consumption and the risk of coronary disease and stroke in women. AU - Stampfer,M J, AU - Colditz,G A, AU - Willett,W C, AU - Speizer,F E, AU - Hennekens,C H, PY - 1988/8/4/pubmed PY - 1988/8/4/medline PY - 1988/8/4/entrez SP - 267 EP - 73 JF - The New England journal of medicine JO - N. Engl. J. Med. VL - 319 IS - 5 N2 - In 1980, 87,526 female nurses 34 to 59 years of age completed a dietary questionnaire that assessed their consumption of beer, wine, and liquor. By 1984, during 334,382 person-years of follow-up, we had documented 200 incident cases of severe coronary heart disease (164 nonfatal myocardial infarctions and 36 deaths due to coronary disease), 66 ischemic strokes, and 28 subarachnoid hemorrhages. Follow-up was 98 percent complete. As compared with nondrinkers, women who consumed 5 to 14 g of alcohol per day (three to nine drinks per week) had a relative risk of coronary disease of 0.6 (95 percent confidence interval, 0.4 to 0.9); for 15 to 24 g per day the relative risk was 0.6 (0.3 to 1.1), and for 25 g or more per day it was 0.4 (0.2 to 0.8), after adjustment for risk factors for coronary disease. Alcohol intake was also associated with a decreased risk of ischemic stroke. For 5 to 14 g of alcohol per day the relative risk was 0.3 (0.1 to 0.7), and for 15 g per day or more it was 0.5 (0.2 to 1.1). In contrast, although the number of cases of subarachnoid hemorrhage was small, alcohol intake tended to be associated with an increased risk of this disorder; for 5 to 14 g per day the relative risk was 3.7 (1.0 to 13.8). These prospective data suggest that among middle-aged women, moderate alcohol consumption decreases the risks of coronary heart disease and ischemic stroke but may increase the risk of subarachnoid hemorrhage. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/3393181/A_prospective_study_of_moderate_alcohol_consumption_and_the_risk_of_coronary_disease_and_stroke_in_women_ L2 - http://www.nejm.org/doi/full/10.1056/NEJM198808043190503?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -