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Vaccine-induced prothrombotic immune thrombocytopenia (VIPIT): Consider IVIG batch in the treatment.
J Thromb Haemost. 2021 May 01 [Online ahead of print]JT

Abstract

Various vaccines have been developed recently to protect the population from corona virus disease-19 (COVID-19). Although the beneficial effects of vaccines outweigh the risks associated with vaccination, an unusual but life threatening thrombosis and thrombocytopenia has been observed in certain individuals who received recombinant adenoviral vector encoding spike protein of SARS-CoV-2 ChAdOx1 nCov-19 (AstraZeneca)1-4 . Exploration of underlying mechanisms have identified that ChAdOx1 nCov-19 vaccine-induced platelet-activating antibodies against platelet factor 4 (PF4) are responsible for these adverse events1-3 . Based on the in vitro experimental evidence that showed therapeutic potential of intravenous immunoglobulin (IVIG), a pooled normal IgG, in preventing the platelet activation by anti-PF4 antibodies, and also founded on the initial experience with IVIG-treatment in these patients1,2 , a recent report by Thaler et al. demonstrated a successful treatment of a vaccine-induced prothrombotic immune thrombocytopenic patient with high dose IVIG therapy5 .

Authors+Show Affiliations

Institut National de la Santé et de la Recherche Médicale, Centre de Recherché des Cordeliers, Sorbonne Université, Université de Paris, 75006, Paris, France.Institut National de la Santé et de la Recherche Médicale, Centre de Recherché des Cordeliers, Sorbonne Université, Université de Paris, 75006, Paris, France.Institut National de la Santé et de la Recherche Médicale, Centre de Recherché des Cordeliers, Sorbonne Université, Université de Paris, 75006, Paris, France.Institut National de la Santé et de la Recherche Médicale, Centre de Recherché des Cordeliers, Sorbonne Université, Université de Paris, 75006, Paris, France. Indian Institute of Technology Palakkad, Palakkad, 678623, Kerala, India.

Pub Type(s)

Letter

Language

eng

PubMed ID

33931935

Citation

Karnam, Anupama, et al. "Vaccine-induced Prothrombotic Immune Thrombocytopenia (VIPIT): Consider IVIG Batch in the Treatment." Journal of Thrombosis and Haemostasis : JTH, 2021.
Karnam A, Lacroix-Desmazes S, Kaveri SV, et al. Vaccine-induced prothrombotic immune thrombocytopenia (VIPIT): Consider IVIG batch in the treatment. J Thromb Haemost. 2021.
Karnam, A., Lacroix-Desmazes, S., Kaveri, S. V., & Bayry, J. (2021). Vaccine-induced prothrombotic immune thrombocytopenia (VIPIT): Consider IVIG batch in the treatment. Journal of Thrombosis and Haemostasis : JTH. https://doi.org/10.1111/jth.15361
Karnam A, et al. Vaccine-induced Prothrombotic Immune Thrombocytopenia (VIPIT): Consider IVIG Batch in the Treatment. J Thromb Haemost. 2021 May 1; PubMed PMID: 33931935.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vaccine-induced prothrombotic immune thrombocytopenia (VIPIT): Consider IVIG batch in the treatment. AU - Karnam,Anupama, AU - Lacroix-Desmazes,Sébastien, AU - Kaveri,Srini V, AU - Bayry,Jagadeesh, Y1 - 2021/05/01/ PY - 2021/5/1/entrez PY - 2021/5/2/pubmed PY - 2021/5/2/medline JF - Journal of thrombosis and haemostasis : JTH JO - J Thromb Haemost N2 - Various vaccines have been developed recently to protect the population from corona virus disease-19 (COVID-19). Although the beneficial effects of vaccines outweigh the risks associated with vaccination, an unusual but life threatening thrombosis and thrombocytopenia has been observed in certain individuals who received recombinant adenoviral vector encoding spike protein of SARS-CoV-2 ChAdOx1 nCov-19 (AstraZeneca)1-4 . Exploration of underlying mechanisms have identified that ChAdOx1 nCov-19 vaccine-induced platelet-activating antibodies against platelet factor 4 (PF4) are responsible for these adverse events1-3 . Based on the in vitro experimental evidence that showed therapeutic potential of intravenous immunoglobulin (IVIG), a pooled normal IgG, in preventing the platelet activation by anti-PF4 antibodies, and also founded on the initial experience with IVIG-treatment in these patients1,2 , a recent report by Thaler et al. demonstrated a successful treatment of a vaccine-induced prothrombotic immune thrombocytopenic patient with high dose IVIG therapy5 . SN - 1538-7836 UR - https://www.unboundmedicine.com/medline/citation/33931935/Vaccine_induced_prothrombotic_immune_thrombocytopenia__VIPIT_:_Consider_IVIG_batch_in_the_treatment_ L2 - https://doi.org/10.1111/jth.15361 DB - PRIME DP - Unbound Medicine ER -
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