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Previously infected vaccinees broadly neutralize SARS-CoV-2 variants.
medRxiv. 2021 Apr 29M

Abstract

We compared the serum neutralizing antibody titers before and after two doses of the BNT162b2 COVID-19 vaccine in ten individuals who recovered from SARS-CoV-2 infection prior to vaccination to 20 individuals with no history of infection, against clinical isolates of B.1.1.7, B.1.351, P.1, and the original SARS-CoV-2 virus. Vaccination boosted pre-existing levels of anti-SARS-CoV-2 spike antibodies 10-fold in previously infected individuals, but not to levels significantly higher than those of uninfected vaccinees. However, neutralizing antibody titers increased in previously infected vaccinees relative to uninfected vaccinees against every variant tested: 5.2-fold against B.1.1.7, 6.5-fold against B.1.351, 4.3-fold against P.1, and 3.4-fold against original SARS-CoV-2. Our study indicates that a first-generation COVID-19 vaccine provides broad protection from SARS-CoV-2variants in individuals with previous infection.

Authors

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Pub Type(s)

Preprint

Language

eng

PubMed ID

33948601

Citation

Leier, Hans C., et al. "Previously Infected Vaccinees Broadly Neutralize SARS-CoV-2 Variants." MedRxiv : the Preprint Server for Health Sciences, 2021.
Leier HC, Bates TA, Lyski ZL, et al. Previously infected vaccinees broadly neutralize SARS-CoV-2 variants. medRxiv. 2021.
Leier, H. C., Bates, T. A., Lyski, Z. L., McBride, S. K., X Lee, D., Coulter, F. J., Goodman, J. R., Lu, Z., Curlin, M. E., Messer, W. B., & Tafesse, F. G. (2021). Previously infected vaccinees broadly neutralize SARS-CoV-2 variants. MedRxiv : the Preprint Server for Health Sciences. https://doi.org/10.1101/2021.04.25.21256049
Leier HC, et al. Previously Infected Vaccinees Broadly Neutralize SARS-CoV-2 Variants. medRxiv. 2021 Apr 29; PubMed PMID: 33948601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Previously infected vaccinees broadly neutralize SARS-CoV-2 variants. AU - Leier,Hans C, AU - Bates,Timothy A, AU - Lyski,Zoe L, AU - McBride,Savannah K, AU - X Lee,David, AU - Coulter,Felicity J, AU - Goodman,James R, AU - Lu,Zhengchun, AU - Curlin,Marcel E, AU - Messer,William B, AU - Tafesse,Fikadu G, Y1 - 2021/04/29/ PY - 2021/5/5/entrez PY - 2021/5/6/pubmed PY - 2021/5/6/medline JF - medRxiv : the preprint server for health sciences JO - medRxiv N2 - We compared the serum neutralizing antibody titers before and after two doses of the BNT162b2 COVID-19 vaccine in ten individuals who recovered from SARS-CoV-2 infection prior to vaccination to 20 individuals with no history of infection, against clinical isolates of B.1.1.7, B.1.351, P.1, and the original SARS-CoV-2 virus. Vaccination boosted pre-existing levels of anti-SARS-CoV-2 spike antibodies 10-fold in previously infected individuals, but not to levels significantly higher than those of uninfected vaccinees. However, neutralizing antibody titers increased in previously infected vaccinees relative to uninfected vaccinees against every variant tested: 5.2-fold against B.1.1.7, 6.5-fold against B.1.351, 4.3-fold against P.1, and 3.4-fold against original SARS-CoV-2. Our study indicates that a first-generation COVID-19 vaccine provides broad protection from SARS-CoV-2variants in individuals with previous infection. UR - https://www.unboundmedicine.com/medline/citation/33948601/Previously_infected_vaccinees_broadly_neutralize_SARS_CoV_2_variants_ L2 - https://doi.org/10.1101/2021.04.25.21256049 DB - PRIME DP - Unbound Medicine ER -
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