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The operational feasibility of vaccination programs targeting influenza risk groups in the WHO African and South-East Asian Regions.
Clin Infect Dis. 2021 May 05 [Online ahead of print]CI

Abstract

BACKGROUND

Influenza vaccination is uncommon in low-resource settings. We evaluated aspects of operational feasibility of influenza vaccination programs targeting risk groups in the WHO African (AFR) and South-East Asian (SEAR) Regions.

METHODS

We estimated routine immunization and influenza vaccination campaign doses, doses per vaccinator, and cold storage requirements for one simulated country in each region using evidence-based population distribution, vaccination schedule, and vaccine volumes. Influenza vaccination targeted persons <5 years, pregnant women, persons with chronic diseases, persons ≥65 years, and healthcare workers (HCW). For the AFR country, we compared vaccine volumes to actual storage capacities.

RESULTS

Targeting HCW had a small operational impact, and subsequent findings exclude this group. During three-month influenza vaccination campaigns, monthly doses delivered in the AFR country increased from 15.0% for ≥65 years to 93.1% for <5 years and in the SEAR country from 19.6% for pregnant women to 145.0% for persons with chronic diseases. National-level cold storage capacity requirements increased in the AFR country from 4.1% for ≥65 years to 20.3% for <5 years and in the SEAR country from 3.9% for pregnant women to 28.8% for persons with chronic diseases. Subnational-level cold storage capacity requirements increased in the AFR country from 5.9% for ≥65 years to 36.8% for <5 years and the SEAR country from 17.6% for pregnant women to 56.0% for persons with chronic diseases.

CONCLUSIONS

Influenza vaccination of most risk groups will require substantial increases in doses, doses per vaccinator, and cold storage capacity in countries where infrastructure and resources are limited.

Authors+Show Affiliations

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.PATH, Seattle, Washington, USA.PATH, Seattle, Washington, USA.Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.Independent Consultant, La Rippe, Switzerland.Centre pour le Développement des Vaccins, Ministère de la Santé, Bamako, Mali.Global Healthcare Consulting, New Delhi, India, and Department of Global Health, Seattle, Washington, USA.Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33949661

Citation

Ortiz, Justin R., et al. "The Operational Feasibility of Vaccination Programs Targeting Influenza Risk Groups in the WHO African and South-East Asian Regions." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 2021.
Ortiz JR, Yu SL, Driscoll AJ, et al. The operational feasibility of vaccination programs targeting influenza risk groups in the WHO African and South-East Asian Regions. Clin Infect Dis. 2021.
Ortiz, J. R., Yu, S. L., Driscoll, A. J., Williams, S. R., Robertson, J., Hsu, J. S., Chen, W. H., Biellik, R. J., Sow, S., Kochhar, S., & Neuzil, K. M. (2021). The operational feasibility of vaccination programs targeting influenza risk groups in the WHO African and South-East Asian Regions. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. https://doi.org/10.1093/cid/ciab393
Ortiz JR, et al. The Operational Feasibility of Vaccination Programs Targeting Influenza Risk Groups in the WHO African and South-East Asian Regions. Clin Infect Dis. 2021 May 5; PubMed PMID: 33949661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The operational feasibility of vaccination programs targeting influenza risk groups in the WHO African and South-East Asian Regions. AU - Ortiz,Justin R, AU - Yu,Stephen L, AU - Driscoll,Amanda J, AU - Williams,Sarah R, AU - Robertson,Joanie, AU - Hsu,Jui-Shan, AU - Chen,Wilbur H, AU - Biellik,Robin J, AU - Sow,Samba, AU - Kochhar,Sonali, AU - Neuzil,Kathleen M, Y1 - 2021/05/05/ PY - 2021/02/10/received PY - 2021/5/5/entrez PY - 2021/5/6/pubmed PY - 2021/5/6/medline KW - Africa KW - South-East Asia KW - immunization KW - influenza KW - influenza vaccine JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis N2 - BACKGROUND: Influenza vaccination is uncommon in low-resource settings. We evaluated aspects of operational feasibility of influenza vaccination programs targeting risk groups in the WHO African (AFR) and South-East Asian (SEAR) Regions. METHODS: We estimated routine immunization and influenza vaccination campaign doses, doses per vaccinator, and cold storage requirements for one simulated country in each region using evidence-based population distribution, vaccination schedule, and vaccine volumes. Influenza vaccination targeted persons <5 years, pregnant women, persons with chronic diseases, persons ≥65 years, and healthcare workers (HCW). For the AFR country, we compared vaccine volumes to actual storage capacities. RESULTS: Targeting HCW had a small operational impact, and subsequent findings exclude this group. During three-month influenza vaccination campaigns, monthly doses delivered in the AFR country increased from 15.0% for ≥65 years to 93.1% for <5 years and in the SEAR country from 19.6% for pregnant women to 145.0% for persons with chronic diseases. National-level cold storage capacity requirements increased in the AFR country from 4.1% for ≥65 years to 20.3% for <5 years and in the SEAR country from 3.9% for pregnant women to 28.8% for persons with chronic diseases. Subnational-level cold storage capacity requirements increased in the AFR country from 5.9% for ≥65 years to 36.8% for <5 years and the SEAR country from 17.6% for pregnant women to 56.0% for persons with chronic diseases. CONCLUSIONS: Influenza vaccination of most risk groups will require substantial increases in doses, doses per vaccinator, and cold storage capacity in countries where infrastructure and resources are limited. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/33949661/The_operational_feasibility_of_vaccination_programs_targeting_influenza_risk_groups_in_the_WHO_African_and_South_East_Asian_Regions_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1093/cid/ciab393 DB - PRIME DP - Unbound Medicine ER -
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