Tags

Type your tag names separated by a space and hit enter

The relationship between COVID-19's severity and ischemic stroke: a systematic review and meta-analysis.
Neurol Sci. 2021 Jul; 42(7):2645-2651.NS

Abstract

OBJECTIVE

We aim to determine the risk of acute ischemic stroke in patients with severe and non-severe coronavirus disease 2019 (COVID-19).

METHODS

A literature search was conducted in the PubMed, Embase, Web of Science, and Cochrane Library databases until October 28, 2020. Studies covering COVID-19's severity classification data and COVID-19 patients with acute ischemic stroke were included. Two independent evaluators extracted data, and the random effects model was used to calculate the risk ratios (RR) and 95% confidence interval (95% CI) of acute ischemic stroke associated with COVID-19's severity.

RESULTS

A total of 8 studies were included, involving 5266 patients. Among all COVID-19 patients, the total incidence of ischemic stroke was 1.76% (95% CI: 0.82-3.01). Severe patients have an increased risk of acute ischemic stroke compared with non-severe patients (RR = 3.53, 95% CI: 2.06-6.07, P < 0.0001; I2 = 12%). This association was also observed when COVID-19's severity was defined by clinical parameters (RR 2.91, 95% CI: 1.17-7.26, P = 0.02; I2 = 29%) and the need for intensive care (RR 4.47, 95% CI: 2.40-8.31, P < 0.0001; I2 = 0%).

CONCLUSIONS

This meta-analysis shows that the severe course of COVID-19 is associated with an increased risk of acute ischemic stroke.

Links

PMC Free PDF

Authors+Show Affiliations

Lu Y
Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Zhao JJ
Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Ye MF
Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Li HM
Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Yao FR
Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China. 67898526@163.com.
Kong Y
Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China. kong0919@163.com.
Xu Z
Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China. xuzhuan772@126.com.

MeSH

Brain IschemiaCOVID-19HumansIschemic StrokeSARS-CoV-2Stroke

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

33954827

Citation

Lu, Yue, et al. "The Relationship Between COVID-19's Severity and Ischemic Stroke: a Systematic Review and Meta-analysis." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 42, no. 7, 2021, pp. 2645-2651.
Lu Y, Zhao JJ, Ye MF, et al. The relationship between COVID-19's severity and ischemic stroke: a systematic review and meta-analysis. Neurol Sci. 2021;42(7):2645-2651.
Lu, Y., Zhao, J. J., Ye, M. F., Li, H. M., Yao, F. R., Kong, Y., & Xu, Z. (2021). The relationship between COVID-19's severity and ischemic stroke: a systematic review and meta-analysis. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 42(7), 2645-2651. https://doi.org/10.1007/s10072-021-05299-8
Lu Y, et al. The Relationship Between COVID-19's Severity and Ischemic Stroke: a Systematic Review and Meta-analysis. Neurol Sci. 2021;42(7):2645-2651. PubMed PMID: 33954827.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between COVID-19's severity and ischemic stroke: a systematic review and meta-analysis. AU - Lu,Yue, AU - Zhao,Jie-Ji, AU - Ye,Meng-Fan, AU - Li,Hong-Mei, AU - Yao,Fei-Rong, AU - Kong,Yan, AU - Xu,Zhuan, Y1 - 2021/05/05/ PY - 2021/01/28/received PY - 2021/04/28/accepted PY - 2021/5/7/pubmed PY - 2021/7/10/medline PY - 2021/5/6/entrez KW - COVID-19 KW - Ischemic stroke KW - Meta-analysis KW - Severity SP - 2645 EP - 2651 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol Sci VL - 42 IS - 7 N2 - OBJECTIVE: We aim to determine the risk of acute ischemic stroke in patients with severe and non-severe coronavirus disease 2019 (COVID-19). METHODS: A literature search was conducted in the PubMed, Embase, Web of Science, and Cochrane Library databases until October 28, 2020. Studies covering COVID-19's severity classification data and COVID-19 patients with acute ischemic stroke were included. Two independent evaluators extracted data, and the random effects model was used to calculate the risk ratios (RR) and 95% confidence interval (95% CI) of acute ischemic stroke associated with COVID-19's severity. RESULTS: A total of 8 studies were included, involving 5266 patients. Among all COVID-19 patients, the total incidence of ischemic stroke was 1.76% (95% CI: 0.82-3.01). Severe patients have an increased risk of acute ischemic stroke compared with non-severe patients (RR = 3.53, 95% CI: 2.06-6.07, P < 0.0001; I2 = 12%). This association was also observed when COVID-19's severity was defined by clinical parameters (RR 2.91, 95% CI: 1.17-7.26, P = 0.02; I2 = 29%) and the need for intensive care (RR 4.47, 95% CI: 2.40-8.31, P < 0.0001; I2 = 0%). CONCLUSIONS: This meta-analysis shows that the severe course of COVID-19 is associated with an increased risk of acute ischemic stroke. SN - 1590-3478 UR - https://www.unboundmedicine.com/medline/citation/33954827/The_relationship_between_COVID_19's_severity_and_ischemic_stroke:_a_systematic_review_and_meta_analysis_ DB - PRIME DP - Unbound Medicine ER -