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Diabetic retinal neurodegeneration as a form of diabetic retinopathy.
Int Ophthalmol. 2021 Sep; 41(9):3223-3248.IO

Abstract

PURPOSE

To review the evidence supporting diabetic retinal neurodegeneration (DRN) as a form of diabetic retinopathy.

METHOD

Review of literature.

RESULTS

DRN is recognized to be a part of retinopathy in patients with diabetes mellitus (DM), in addition to the well-established diabetic retinal vasculopathy (DRV). DRN has been noted in the early stages of DM, before the onset of clinically evident diabetic retinopathy. The occurrence of DRN has been confirmed in animal models of DM, histopathological examination of donor's eyes from diabetic individuals and assessment of neural structure and function in humans. DRN involves alterations in retinal ganglion cells, photoreceptors, amacrine cells and bipolar cells, and is thought to be driven by glutamate, oxidative stress and dysregulation of neuroprotective factors in the retina. Potential therapeutic options for DRN are under evaluation.

CONCLUSIONS

Literature is divided on the temporal relation between DRN and DRV, with evidence of both precedence and simultaneous occurrence. The relationship between DRN and multi-system neuropathy in DM is yet to be evaluated critically.

Authors+Show Affiliations

Department of Ophthalmology, All India Institute of Medical Sciences-Bhopal, Bhopal, India.Department of Vitreo-Retina, Sankara Eye Hospital, Shivamogga, India.Smt. Kanuri Santhamma Center for Vitreoretinal Diseases, L. V. Prasad Eye Institute, Hyderabad, India. britak.aiims@gmail.com. Indian Health Outcomes, Public Health and Economics Research (IHOPE) Centre, L. V. Prasad Eye Institute, Hyderabad, India. britak.aiims@gmail.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33954860

Citation

Soni, Deepak, et al. "Diabetic Retinal Neurodegeneration as a Form of Diabetic Retinopathy." International Ophthalmology, vol. 41, no. 9, 2021, pp. 3223-3248.
Soni D, Sagar P, Takkar B. Diabetic retinal neurodegeneration as a form of diabetic retinopathy. Int Ophthalmol. 2021;41(9):3223-3248.
Soni, D., Sagar, P., & Takkar, B. (2021). Diabetic retinal neurodegeneration as a form of diabetic retinopathy. International Ophthalmology, 41(9), 3223-3248. https://doi.org/10.1007/s10792-021-01864-4
Soni D, Sagar P, Takkar B. Diabetic Retinal Neurodegeneration as a Form of Diabetic Retinopathy. Int Ophthalmol. 2021;41(9):3223-3248. PubMed PMID: 33954860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetic retinal neurodegeneration as a form of diabetic retinopathy. AU - Soni,Deepak, AU - Sagar,Pradeep, AU - Takkar,Brijesh, Y1 - 2021/05/06/ PY - 2020/12/02/received PY - 2021/04/08/accepted PY - 2021/5/7/pubmed PY - 2021/8/18/medline PY - 2021/5/6/entrez KW - Diabetes mellitus KW - Diabetic neuropathy KW - Diabetic retinal neurodegeneration KW - Diabetic retinopathy KW - Microvascular complications of diabetes SP - 3223 EP - 3248 JF - International ophthalmology JO - Int Ophthalmol VL - 41 IS - 9 N2 - PURPOSE: To review the evidence supporting diabetic retinal neurodegeneration (DRN) as a form of diabetic retinopathy. METHOD: Review of literature. RESULTS: DRN is recognized to be a part of retinopathy in patients with diabetes mellitus (DM), in addition to the well-established diabetic retinal vasculopathy (DRV). DRN has been noted in the early stages of DM, before the onset of clinically evident diabetic retinopathy. The occurrence of DRN has been confirmed in animal models of DM, histopathological examination of donor's eyes from diabetic individuals and assessment of neural structure and function in humans. DRN involves alterations in retinal ganglion cells, photoreceptors, amacrine cells and bipolar cells, and is thought to be driven by glutamate, oxidative stress and dysregulation of neuroprotective factors in the retina. Potential therapeutic options for DRN are under evaluation. CONCLUSIONS: Literature is divided on the temporal relation between DRN and DRV, with evidence of both precedence and simultaneous occurrence. The relationship between DRN and multi-system neuropathy in DM is yet to be evaluated critically. SN - 1573-2630 UR - https://www.unboundmedicine.com/medline/citation/33954860/Diabetic_retinal_neurodegeneration_as_a_form_of_diabetic_retinopathy_ L2 - https://doi.org/10.1007/s10792-021-01864-4 DB - PRIME DP - Unbound Medicine ER -