Tags

Type your tag names separated by a space and hit enter

CBG, CBD, Δ9-THC, CBN, CBGA, CBDA and Δ9-THCA as antioxidant agents and their intervention abilities in antioxidant action.
Fitoterapia. 2021 Jul; 152:104915.F

Abstract

Positive effect of some cannabinoids in the treatment and prophylaxis of a wide variety of oxidation-associated diseases and growing popularity of supplements containing cannabinoids, mainly cannabinoid oils (e.g. CBD oil, CBG oil), in the self-medication of humans cause a growing interest in the antioxidant properties of these compounds, especially those not showing psychotropic effects. Herein, we report the antioxidant activity of cannabigerol (CBG), cannabidiol (CBD), Δ9-tetrahydrocannabinol (Δ9-THC), cannabinol (CBN), cannabigerolic acid (CBGA), cannabinolic acid (CBDA) and Δ9-tetrahydrocannabinolic acid (Δ9-THCA) estimated by spectrophotometric methods: ABTS, DPPH, ORAC, beta-carotene CUPRAC and FRAP. The presented data prove that all the examined cannabinoids exhibit antioxidant activity manifested in their ability to scavenge free radicals, to prevent the oxidation process and to reduce metal ions. Although the intensity of these activities is not the same for the individual cannabinoids it is comparable for all of them with that of E vitamin. As results from the research, the significance of the two types of electron sources presenting in examined cannabinoids, phenolic groups and double bonds transferring electrons, depends on the type of electron-accepting species - radicals/metal ions.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Dawidowicz AL
Department of Chromatography, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Sklodowska University in Lublin, Pl. Marii Curie Sklodowskiej 3, Lublin 20-031, Poland. Electronic address: dawid@poczta.umcs.lublin.pl.
Olszowy-Tomczyk M
Department of Chromatography, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Sklodowska University in Lublin, Pl. Marii Curie Sklodowskiej 3, Lublin 20-031, Poland.
Typek R
Department of Chromatography, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Sklodowska University in Lublin, Pl. Marii Curie Sklodowskiej 3, Lublin 20-031, Poland.

MeSH

AntioxidantsBenzoatesCannabidiolCannabinoidsCannabinolCannabisMolecular Structure

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33964342

Citation

Dawidowicz, Andrzej L., et al. "CBG, CBD, Δ9-THC, CBN, CBGA, CBDA and Δ9-THCA as Antioxidant Agents and Their Intervention Abilities in Antioxidant Action." Fitoterapia, vol. 152, 2021, p. 104915.
Dawidowicz AL, Olszowy-Tomczyk M, Typek R. CBG, CBD, Δ9-THC, CBN, CBGA, CBDA and Δ9-THCA as antioxidant agents and their intervention abilities in antioxidant action. Fitoterapia. 2021;152:104915.
Dawidowicz, A. L., Olszowy-Tomczyk, M., & Typek, R. (2021). CBG, CBD, Δ9-THC, CBN, CBGA, CBDA and Δ9-THCA as antioxidant agents and their intervention abilities in antioxidant action. Fitoterapia, 152, 104915. https://doi.org/10.1016/j.fitote.2021.104915
Dawidowicz AL, Olszowy-Tomczyk M, Typek R. CBG, CBD, Δ9-THC, CBN, CBGA, CBDA and Δ9-THCA as Antioxidant Agents and Their Intervention Abilities in Antioxidant Action. Fitoterapia. 2021;152:104915. PubMed PMID: 33964342.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CBG, CBD, Δ9-THC, CBN, CBGA, CBDA and Δ9-THCA as antioxidant agents and their intervention abilities in antioxidant action. AU - Dawidowicz,Andrzej L, AU - Olszowy-Tomczyk,Małgorzata, AU - Typek,Rafał, Y1 - 2021/05/06/ PY - 2021/02/25/received PY - 2021/04/27/revised PY - 2021/04/28/accepted PY - 2021/5/9/pubmed PY - 2021/9/16/medline PY - 2021/5/8/entrez KW - Acidic cannabinoids, antioxidant activity KW - Cannabinoids KW - Cannabis KW - Hemp KW - Reduction potential SP - 104915 EP - 104915 JF - Fitoterapia JO - Fitoterapia VL - 152 N2 - Positive effect of some cannabinoids in the treatment and prophylaxis of a wide variety of oxidation-associated diseases and growing popularity of supplements containing cannabinoids, mainly cannabinoid oils (e.g. CBD oil, CBG oil), in the self-medication of humans cause a growing interest in the antioxidant properties of these compounds, especially those not showing psychotropic effects. Herein, we report the antioxidant activity of cannabigerol (CBG), cannabidiol (CBD), Δ9-tetrahydrocannabinol (Δ9-THC), cannabinol (CBN), cannabigerolic acid (CBGA), cannabinolic acid (CBDA) and Δ9-tetrahydrocannabinolic acid (Δ9-THCA) estimated by spectrophotometric methods: ABTS, DPPH, ORAC, beta-carotene CUPRAC and FRAP. The presented data prove that all the examined cannabinoids exhibit antioxidant activity manifested in their ability to scavenge free radicals, to prevent the oxidation process and to reduce metal ions. Although the intensity of these activities is not the same for the individual cannabinoids it is comparable for all of them with that of E vitamin. As results from the research, the significance of the two types of electron sources presenting in examined cannabinoids, phenolic groups and double bonds transferring electrons, depends on the type of electron-accepting species - radicals/metal ions. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/33964342/CBG_CBD_Δ9_THC_CBN_CBGA_CBDA_and_Δ9_THCA_as_antioxidant_agents_and_their_intervention_abilities_in_antioxidant_action_ DB - PRIME DP - Unbound Medicine ER -