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Meta-transcriptomic profiling of functional variation of freshwater microbial communities induced by an antidepressant sertraline hydrochloride.
Sci Total Environ. 2021 Sep 10; 786:147434.ST

Abstract

Sertraline hydrochloride (Ser-HCl) is an effective and commonly used antidepressant drug, which is also frequently detected in aquatic environments. Our previous research showed that Ser-HCl changes the community composition of aquatic microbiome, but the understanding of the expression of functional pathways in microbial communities is still incomplete; to address this knowledge gap, we used meta-transcriptomics analysis to evaluate the toxicity of Ser-HCl to natural aquatic microbial communities cultured in laboratory microcosms. Meta-transcriptomic results show that a 15-day exposure to 50 μg/L Ser-HCl significantly changed the functional expression activity of aquatic microbial communities. Pathways related to lipid metabolism, energy metabolism, membrane transport function, and genetic information processing in the aquatic microbial community were severely inhibited under Ser-HCl treatment, but metabolism of cofactors and vitamins to alleviate biological toxicity after Ser-HCl exposure was enhanced. Our study thus reveals details of the effects of sertraline on the functioning of aquatic microbiome. Due to the extensive use of Ser-HCl and its strong biological activity, it should not continue to be an overlooked pollutant. Therefore, more attention should be paid to the negative effects of such biologically active drugs on the expression of aquatic microbiome.

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Publisher Full Text (DOI)

Authors+Show Affiliations

College of Environment, Zhejiang University of Technology, Hangzhou 310014, PR China.

College of Environment, Zhejiang University of Technology, Hangzhou 310014, PR China.

College of Environment, Zhejiang University of Technology, Hangzhou 310014, PR China.

College of Environment, Zhejiang University of Technology, Hangzhou 310014, PR China.

College of Environment, Zhejiang University of Technology, Hangzhou 310014, PR China.

College of Environment, Zhejiang University of Technology, Hangzhou 310014, PR China.

College of Environment, Zhejiang University of Technology, Hangzhou 310014, PR China. Electronic address: lutao@zjut.edu.cn.

College of Environment, Zhejiang University of Technology, Hangzhou 310014, PR China.

MeSH

Antidepressive AgentsFresh WaterMicrobiotaSertralineTranscriptomeWater Pollutants, Chemical

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33964776

Citation

Cui, Hengzheng, et al. "Meta-transcriptomic Profiling of Functional Variation of Freshwater Microbial Communities Induced By an Antidepressant Sertraline Hydrochloride." The Science of the Total Environment, vol. 786, 2021, p. 147434.

Cui H, Zhou W, Deng Y, et al. Meta-transcriptomic profiling of functional variation of freshwater microbial communities induced by an antidepressant sertraline hydrochloride. Sci Total Environ. 2021;786:147434.

Cui, H., Zhou, W., Deng, Y., Zheng, B., Zhang, Q., Zhang, Z., Lu, T., & Qian, H. (2021). Meta-transcriptomic profiling of functional variation of freshwater microbial communities induced by an antidepressant sertraline hydrochloride. The Science of the Total Environment, 786, 147434. https://doi.org/10.1016/j.scitotenv.2021.147434

Cui H, et al. Meta-transcriptomic Profiling of Functional Variation of Freshwater Microbial Communities Induced By an Antidepressant Sertraline Hydrochloride. Sci Total Environ. 2021 Sep 10;786:147434. PubMed PMID: 33964776.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Meta-transcriptomic profiling of functional variation of freshwater microbial communities induced by an antidepressant sertraline hydrochloride. AU - Cui,Hengzheng, AU - Zhou,Wenya, AU - Deng,Yu, AU - Zheng,Binyu, AU - Zhang,Qi, AU - Zhang,Zhenyan, AU - Lu,Tao, AU - Qian,Haifeng, Y1 - 2021/04/30/ PY - 2021/03/05/received PY - 2021/04/24/revised PY - 2021/04/26/accepted PY - 2021/5/9/pubmed PY - 2021/6/11/medline PY - 2021/5/8/entrez KW - Antidepressant drugs KW - Aquatic toxicology KW - Meta-transcriptome KW - Microecological balance SP - 147434 EP - 147434 JF - The Science of the total environment JO - Sci Total Environ VL - 786 N2 - Sertraline hydrochloride (Ser-HCl) is an effective and commonly used antidepressant drug, which is also frequently detected in aquatic environments. Our previous research showed that Ser-HCl changes the community composition of aquatic microbiome, but the understanding of the expression of functional pathways in microbial communities is still incomplete; to address this knowledge gap, we used meta-transcriptomics analysis to evaluate the toxicity of Ser-HCl to natural aquatic microbial communities cultured in laboratory microcosms. Meta-transcriptomic results show that a 15-day exposure to 50 μg/L Ser-HCl significantly changed the functional expression activity of aquatic microbial communities. Pathways related to lipid metabolism, energy metabolism, membrane transport function, and genetic information processing in the aquatic microbial community were severely inhibited under Ser-HCl treatment, but metabolism of cofactors and vitamins to alleviate biological toxicity after Ser-HCl exposure was enhanced. Our study thus reveals details of the effects of sertraline on the functioning of aquatic microbiome. Due to the extensive use of Ser-HCl and its strong biological activity, it should not continue to be an overlooked pollutant. Therefore, more attention should be paid to the negative effects of such biologically active drugs on the expression of aquatic microbiome. SN - 1879-1026 UR - https://www.unboundmedicine.com/medline/citation/33964776/Meta_transcriptomic_profiling_of_functional_variation_of_freshwater_microbial_communities_induced_by_an_antidepressant_sertraline_hydrochloride_ DB - PRIME DP - Unbound Medicine ER -