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Açaí (Euterpe oleracea Martius) supplementation improves oxidative stress biomarkers in liver tissue of dams fed a high-fat diet and increases antioxidant enzymes' gene expression in offspring.
Biomed Pharmacother. 2021 Jul; 139:111627.BP

Abstract

Lipids excess from an uterine environment can increase free radicals production of and thus induce oxidative status imbalance, a key factor for progression of non-alcoholic fatty liver disease (NAFLD) in offspring. Food antioxidant components in maternal diet may play an important role in preventing offspring metabolic disorders. The objective of the study was to evaluate the effects of açaí pulp supplementation on maternal high-fat diet, by assessing activity and expression of antioxidant enzymes and biomarkers of oxidative stress in the liver. Female Fisher rats were divided into four groups and fed a control diet (C), a high-fat diet (HF), a control diet supplemented with açaí (CA) and a high-fat diet supplemented with açaí (HFA) before mating, during gestation and lactation. The effects of açaí supplementation on oxidative stress biomarkers and antioxidant enzymes expression were evaluated in dams and male offspring after weaning. HFA diet increased body weight in dams, however reduced absolute and relative liver weight. There was a reduction in liver biomarkers of oxidative stress, malondialdehyde and carbonyl protein, as well as in catalase, glutathione peroxidase and superoxide dismutase activity. In offspring, HFA diet reduced liver weight and increased Gpx1, Gpx4 and Sod1 mRNA expression. These results suggest that açaí is able to restore redox status, preventing oxidative damage in dams by a direct mechanism and to promote beneficial effects on expression of antioxidant defences related genes in offspring.

Authors+Show Affiliations

Nucleus of Research in Biological Sciences (NUPEB), Universidade Federal de Ouro Preto, Minas Gerais, Brazil.School of Nutrition, Universidade Federal de Ouro Preto, Minas Gerais, Brazil.School of Nutrition, Universidade Federal de Ouro Preto, Minas Gerais, Brazil.School of Nutrition, Universidade Federal de Ouro Preto, Minas Gerais, Brazil.Nucleus of Research in Biological Sciences (NUPEB), Universidade Federal de Ouro Preto, Minas Gerais, Brazil; School of Nutrition, Universidade Federal de Ouro Preto, Minas Gerais, Brazil.Centre for Obesity Research and Education, School of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen, UK.Nucleus of Research in Biological Sciences (NUPEB), Universidade Federal de Ouro Preto, Minas Gerais, Brazil; School of Nutrition, Universidade Federal de Ouro Preto, Minas Gerais, Brazil. Electronic address: renata.freitas@ufop.edu.br.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33965728

Citation

Barbosa, Priscila O., et al. "Açaí (Euterpe Oleracea Martius) Supplementation Improves Oxidative Stress Biomarkers in Liver Tissue of Dams Fed a High-fat Diet and Increases Antioxidant Enzymes' Gene Expression in Offspring." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 139, 2021, p. 111627.
Barbosa PO, Souza MO, Silva MPS, et al. Açaí (Euterpe oleracea Martius) supplementation improves oxidative stress biomarkers in liver tissue of dams fed a high-fat diet and increases antioxidant enzymes' gene expression in offspring. Biomed Pharmacother. 2021;139:111627.
Barbosa, P. O., Souza, M. O., Silva, M. P. S., Santos, G. T., Silva, M. E., Bermano, G., & Freitas, R. N. (2021). Açaí (Euterpe oleracea Martius) supplementation improves oxidative stress biomarkers in liver tissue of dams fed a high-fat diet and increases antioxidant enzymes' gene expression in offspring. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 139, 111627. https://doi.org/10.1016/j.biopha.2021.111627
Barbosa PO, et al. Açaí (Euterpe Oleracea Martius) Supplementation Improves Oxidative Stress Biomarkers in Liver Tissue of Dams Fed a High-fat Diet and Increases Antioxidant Enzymes' Gene Expression in Offspring. Biomed Pharmacother. 2021;139:111627. PubMed PMID: 33965728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Açaí (Euterpe oleracea Martius) supplementation improves oxidative stress biomarkers in liver tissue of dams fed a high-fat diet and increases antioxidant enzymes' gene expression in offspring. AU - Barbosa,Priscila O, AU - Souza,Melina O, AU - Silva,Maraísa P S, AU - Santos,Gabrielly T, AU - Silva,Marcelo E, AU - Bermano,Giovanna, AU - Freitas,Renata N, Y1 - 2021/05/06/ PY - 2020/11/19/received PY - 2021/04/12/revised PY - 2021/04/13/accepted PY - 2021/5/10/pubmed PY - 2021/7/27/medline PY - 2021/5/9/entrez KW - Açaí KW - Euterpe oleracea Martius KW - Maternal high-fat diet KW - Offspring KW - Oxidative stress KW - Redox metabolism SP - 111627 EP - 111627 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 139 N2 - Lipids excess from an uterine environment can increase free radicals production of and thus induce oxidative status imbalance, a key factor for progression of non-alcoholic fatty liver disease (NAFLD) in offspring. Food antioxidant components in maternal diet may play an important role in preventing offspring metabolic disorders. The objective of the study was to evaluate the effects of açaí pulp supplementation on maternal high-fat diet, by assessing activity and expression of antioxidant enzymes and biomarkers of oxidative stress in the liver. Female Fisher rats were divided into four groups and fed a control diet (C), a high-fat diet (HF), a control diet supplemented with açaí (CA) and a high-fat diet supplemented with açaí (HFA) before mating, during gestation and lactation. The effects of açaí supplementation on oxidative stress biomarkers and antioxidant enzymes expression were evaluated in dams and male offspring after weaning. HFA diet increased body weight in dams, however reduced absolute and relative liver weight. There was a reduction in liver biomarkers of oxidative stress, malondialdehyde and carbonyl protein, as well as in catalase, glutathione peroxidase and superoxide dismutase activity. In offspring, HFA diet reduced liver weight and increased Gpx1, Gpx4 and Sod1 mRNA expression. These results suggest that açaí is able to restore redox status, preventing oxidative damage in dams by a direct mechanism and to promote beneficial effects on expression of antioxidant defences related genes in offspring. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/33965728/Açaí__Euterpe_oleracea_Martius__supplementation_improves_oxidative_stress_biomarkers_in_liver_tissue_of_dams_fed_a_high_fat_diet_and_increases_antioxidant_enzymes'_gene_expression_in_offspring_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(21)00412-1 DB - PRIME DP - Unbound Medicine ER -