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Immunoglobulin A antigliadin antibodies in jejunal juice: markers of severe intestinal damage in coeliac children.
Digestion. 1988; 39(1):35-9.D

Abstract

Antibodies to gliadin (AGA), detected in jejunal juice by immunofluorescence and enzyme-linked immunosorbent assay, have been found in 13 of 15 (87%) children with untreated coeliac disease. Jejunal AGA were also positive in 6 of the 9 (67%) coeliac children on gluten challenge, while they were consistently negative in coeliac children on a gluten-free diet and in controls. Jejunal AGA were always of immunoglobulin A (IgA) class, associated with IgM in some cases. Moreover, the presence of IgA AGA in jejunal juice was strictly related to the severity of intestinal damage. These data suggest that IgA AGA, detected in jejunal juice are synthesized from gut mucosa and are markers of its abnormal function. Like AGA, antibodies to milk and egg proteins were only found in jejunal juice of coeliac patients with flat intestinal mucosa, but their prevalence was significantly lower than that of AGA.

Authors+Show Affiliations

Istituto di Clinica Medica II, Università di Bologna, Italia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3396771

Citation

Volta, U, et al. "Immunoglobulin a Antigliadin Antibodies in Jejunal Juice: Markers of Severe Intestinal Damage in Coeliac Children." Digestion, vol. 39, no. 1, 1988, pp. 35-9.
Volta U, Bonazzi C, Lazzari R, et al. Immunoglobulin A antigliadin antibodies in jejunal juice: markers of severe intestinal damage in coeliac children. Digestion. 1988;39(1):35-9.
Volta, U., Bonazzi, C., Lazzari, R., Baldoni, A. M., Collina, A., Bianchi, F. B., & Pisi, E. (1988). Immunoglobulin A antigliadin antibodies in jejunal juice: markers of severe intestinal damage in coeliac children. Digestion, 39(1), 35-9.
Volta U, et al. Immunoglobulin a Antigliadin Antibodies in Jejunal Juice: Markers of Severe Intestinal Damage in Coeliac Children. Digestion. 1988;39(1):35-9. PubMed PMID: 3396771.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunoglobulin A antigliadin antibodies in jejunal juice: markers of severe intestinal damage in coeliac children. AU - Volta,U, AU - Bonazzi,C, AU - Lazzari,R, AU - Baldoni,A M, AU - Collina,A, AU - Bianchi,F B, AU - Pisi,E, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 35 EP - 9 JF - Digestion JO - Digestion VL - 39 IS - 1 N2 - Antibodies to gliadin (AGA), detected in jejunal juice by immunofluorescence and enzyme-linked immunosorbent assay, have been found in 13 of 15 (87%) children with untreated coeliac disease. Jejunal AGA were also positive in 6 of the 9 (67%) coeliac children on gluten challenge, while they were consistently negative in coeliac children on a gluten-free diet and in controls. Jejunal AGA were always of immunoglobulin A (IgA) class, associated with IgM in some cases. Moreover, the presence of IgA AGA in jejunal juice was strictly related to the severity of intestinal damage. These data suggest that IgA AGA, detected in jejunal juice are synthesized from gut mucosa and are markers of its abnormal function. Like AGA, antibodies to milk and egg proteins were only found in jejunal juice of coeliac patients with flat intestinal mucosa, but their prevalence was significantly lower than that of AGA. SN - 0012-2823 UR - https://www.unboundmedicine.com/medline/citation/3396771/Immunoglobulin_A_antigliadin_antibodies_in_jejunal_juice:_markers_of_severe_intestinal_damage_in_coeliac_children_ L2 - https://www.karger.com?DOI=10.1159/000199605 DB - PRIME DP - Unbound Medicine ER -