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Epidemiology of cannabidiol related cases reported in the National Poison Data System - 2019-2020.
Am J Emerg Med. 2021 10; 48:218-223.AJ

Abstract

INTRODUCTION

Cannabidiol (CBD) has become a popular supplement in consumer products in recent years, resulting in part from normalization of the cultivation of low THC cannabis in 2018. However, the actual content of CBD-labeled products is frequently uncertain, as oversight of such products is minimal. To date, there is little pragmatic knowledge regarding exposures to products labeled as containing CBD.

METHODS

Cases reported to Poison Control Centers from April 1, 2019 and March 31, 2020, the first year in which CBD was identified uniquely as a substance in the National Poison Data System, were analyzed for demographic, temporal, and clinical trends.

RESULTS

Poison Control Centers handled 1581 cases exposures to CBD-containing products between April 1, 2019 and March 31, 2020. There was a significant trend of over 5 additional cases related to this substance per month (linear regression coefficient = 5.2, 95% CI: 1.52-8.98). Patients under age 13 years made up 44.0% of reported exposures. Mild CNS depression (10.3%), tachycardia (5.7%), dizziness/vertigo (5.3%), vomiting (4.9%), nausea (4.5%), and agitation (4.4%) were the most frequently reported symptoms. 13% of cases were coded as having "moderate" or "severe" medical outcomes. There were no fatalities.

CONCLUSIONS

Cases reported to Poison Control Centers regarding exposures to CBD-labeled products have been increasing, representing an emerging trend of interest to Poison Control Center professionals, clinicians, and public health officials. Further monitoring of this trend is recommended.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Berger BA
Department of Emergency Medicine, 231 Albert Sabin Way, MSB 1654, ML 0769, Cincinnati, OH 45267, USA. Electronic address: brandon.berger@uc.edu.
Stolz U
Department of Emergency Medicine, 231 Albert Sabin Way, MSB 1654, ML 0769, Cincinnati, OH 45267, USA.
Colvin J
Cincinnati Drug and Poison Information Center, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH 45229, USA.
Otten EJ
Department of Emergency Medicine, 231 Albert Sabin Way, MSB 1654, ML 0769, Cincinnati, OH 45267, USA; Cincinnati Drug and Poison Information Center, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH 45229, USA.

MeSH

AdolescentAdultAgedAnticonvulsantsCannabidiolChildChild, PreschoolDatabases, FactualDizzinessFemaleHumansInfantMaleMiddle AgedNauseaNeurotoxicity SyndromesPoison Control CentersTachycardiaUnited StatesVertigoVomitingYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33975134

Citation

Berger, Brandon A., et al. "Epidemiology of Cannabidiol Related Cases Reported in the National Poison Data System - 2019-2020." The American Journal of Emergency Medicine, vol. 48, 2021, pp. 218-223.
Berger BA, Stolz U, Colvin J, et al. Epidemiology of cannabidiol related cases reported in the National Poison Data System - 2019-2020. Am J Emerg Med. 2021;48:218-223.
Berger, B. A., Stolz, U., Colvin, J., & Otten, E. J. (2021). Epidemiology of cannabidiol related cases reported in the National Poison Data System - 2019-2020. The American Journal of Emergency Medicine, 48, 218-223. https://doi.org/10.1016/j.ajem.2021.04.065
Berger BA, et al. Epidemiology of Cannabidiol Related Cases Reported in the National Poison Data System - 2019-2020. Am J Emerg Med. 2021;48:218-223. PubMed PMID: 33975134.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology of cannabidiol related cases reported in the National Poison Data System - 2019-2020. AU - Berger,Brandon A, AU - Stolz,Uwe, AU - Colvin,Jonathan, AU - Otten,Edward J, Y1 - 2021/04/23/ PY - 2021/02/08/received PY - 2021/04/20/revised PY - 2021/04/20/accepted PY - 2021/5/12/pubmed PY - 2021/10/26/medline PY - 2021/5/11/entrez KW - CBD KW - Cannabidiol KW - Cannabis sativa KW - National Poison Data System KW - Poison control center SP - 218 EP - 223 JF - The American journal of emergency medicine JO - Am J Emerg Med VL - 48 N2 - INTRODUCTION: Cannabidiol (CBD) has become a popular supplement in consumer products in recent years, resulting in part from normalization of the cultivation of low THC cannabis in 2018. However, the actual content of CBD-labeled products is frequently uncertain, as oversight of such products is minimal. To date, there is little pragmatic knowledge regarding exposures to products labeled as containing CBD. METHODS: Cases reported to Poison Control Centers from April 1, 2019 and March 31, 2020, the first year in which CBD was identified uniquely as a substance in the National Poison Data System, were analyzed for demographic, temporal, and clinical trends. RESULTS: Poison Control Centers handled 1581 cases exposures to CBD-containing products between April 1, 2019 and March 31, 2020. There was a significant trend of over 5 additional cases related to this substance per month (linear regression coefficient = 5.2, 95% CI: 1.52-8.98). Patients under age 13 years made up 44.0% of reported exposures. Mild CNS depression (10.3%), tachycardia (5.7%), dizziness/vertigo (5.3%), vomiting (4.9%), nausea (4.5%), and agitation (4.4%) were the most frequently reported symptoms. 13% of cases were coded as having "moderate" or "severe" medical outcomes. There were no fatalities. CONCLUSIONS: Cases reported to Poison Control Centers regarding exposures to CBD-labeled products have been increasing, representing an emerging trend of interest to Poison Control Center professionals, clinicians, and public health officials. Further monitoring of this trend is recommended. SN - 1532-8171 UR - https://www.unboundmedicine.com/medline/citation/33975134/Epidemiology_of_cannabidiol_related_cases_reported_in_the_National_Poison_Data_System___2019_2020_ DB - PRIME DP - Unbound Medicine ER -