Tags

Type your tag names separated by a space and hit enter

Diabetes diminishes a typical metabolite of litchi pericarp oligomeric procyanidins (LPOPC) in urine mediated by imbalanced gut microbiota.
Food Funct. 2021 Jun 21; 12(12):5375-5386.FF

Abstract

Animal studies and clinical trials have shown that dietary polyphenols and polyphenol-rich foods can reduce the risk of type 2 diabetes (T2D) and its complications, but how diabetes regulates the metabolism of polyphenol has not been fully elucidated. This study investigated the effects of diabetes on litchi pericarp oligomeric procyanidin (LPOPC) dynamic metabolism and its major static metabolites in urine. First, a high-fat and streptozotocin (STZ)-induced diabetic Sprague Dawley (SD) rat model was established. In the diabetic rat model, elevated fasting blood glucose, severely impaired glucose tolerance test, and increased reactive oxygen species (ROS) levels in serum and the liver were observed. Subsequently, 200 mg per kg body weight of LPOPC was administrated to control and diabetic SD rats, and the gastrointestinal tract was collected at 0.5 h, 1 h, 3 h, and 6 h. The results showed that the retention time of LPOPC was not changed in our diabetic rat model. However, the gut microbiota were significantly altered, with elevated Proteobacteria and Verrucomicrobia abundance in diabetic rats and decreased short chain fatty acid (SCFA)-producing bacteria. Interestingly, after one dose of 300 mg per kg body weight LPOPC, the total antioxidant capacity of urine in diabetic rats significantly decreased. We then tested the static metabolites of LPOPC, demonstrating that epicatechin had not changed in urine in diabetic rats, but that shikimic acid was significantly reduced in urine in diabetic rats. The changes in shikimic acid may be due to the alteration of gut microbiota and elevated ROS levels in serum.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Li X
School of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
Sui Y
Institute for Farm Products Processing and Nuclear-Agricultural Technology, Hubei Academy of Agricultural Science, 430068, Wuhan, China.
Xie B
College of Food Science and Technology, Huazhong Agricultural University, Wuhan, China. sunzhida@sina.com.
Sun Z
College of Food Science and Technology, Huazhong Agricultural University, Wuhan, China. sunzhida@sina.com.
Li S
School of Food Science and Engineering, Wuhan Polytechnic University, Wuhan, China. lishuyisz@sina.com.

MeSH

AnimalsAntioxidantsBiflavonoidsCatechinDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2FastingFruitGastrointestinal MicrobiomeLitchiMalePlant ExtractsProanthocyanidinsRNA, Ribosomal, 16SRatsRats, Sprague-Dawley

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33982735

Citation

Li, Xiaopeng, et al. "Diabetes Diminishes a Typical Metabolite of Litchi Pericarp Oligomeric Procyanidins (LPOPC) in Urine Mediated By Imbalanced Gut Microbiota." Food & Function, vol. 12, no. 12, 2021, pp. 5375-5386.
Li X, Sui Y, Xie B, et al. Diabetes diminishes a typical metabolite of litchi pericarp oligomeric procyanidins (LPOPC) in urine mediated by imbalanced gut microbiota. Food Funct. 2021;12(12):5375-5386.
Li, X., Sui, Y., Xie, B., Sun, Z., & Li, S. (2021). Diabetes diminishes a typical metabolite of litchi pericarp oligomeric procyanidins (LPOPC) in urine mediated by imbalanced gut microbiota. Food & Function, 12(12), 5375-5386. https://doi.org/10.1039/d1fo00587a
Li X, et al. Diabetes Diminishes a Typical Metabolite of Litchi Pericarp Oligomeric Procyanidins (LPOPC) in Urine Mediated By Imbalanced Gut Microbiota. Food Funct. 2021 Jun 21;12(12):5375-5386. PubMed PMID: 33982735.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetes diminishes a typical metabolite of litchi pericarp oligomeric procyanidins (LPOPC) in urine mediated by imbalanced gut microbiota. AU - Li,Xiaopeng, AU - Sui,Yong, AU - Xie,Bijun, AU - Sun,Zhida, AU - Li,Shuyi, PY - 2021/5/14/pubmed PY - 2021/11/24/medline PY - 2021/5/13/entrez SP - 5375 EP - 5386 JF - Food & function JO - Food Funct VL - 12 IS - 12 N2 - Animal studies and clinical trials have shown that dietary polyphenols and polyphenol-rich foods can reduce the risk of type 2 diabetes (T2D) and its complications, but how diabetes regulates the metabolism of polyphenol has not been fully elucidated. This study investigated the effects of diabetes on litchi pericarp oligomeric procyanidin (LPOPC) dynamic metabolism and its major static metabolites in urine. First, a high-fat and streptozotocin (STZ)-induced diabetic Sprague Dawley (SD) rat model was established. In the diabetic rat model, elevated fasting blood glucose, severely impaired glucose tolerance test, and increased reactive oxygen species (ROS) levels in serum and the liver were observed. Subsequently, 200 mg per kg body weight of LPOPC was administrated to control and diabetic SD rats, and the gastrointestinal tract was collected at 0.5 h, 1 h, 3 h, and 6 h. The results showed that the retention time of LPOPC was not changed in our diabetic rat model. However, the gut microbiota were significantly altered, with elevated Proteobacteria and Verrucomicrobia abundance in diabetic rats and decreased short chain fatty acid (SCFA)-producing bacteria. Interestingly, after one dose of 300 mg per kg body weight LPOPC, the total antioxidant capacity of urine in diabetic rats significantly decreased. We then tested the static metabolites of LPOPC, demonstrating that epicatechin had not changed in urine in diabetic rats, but that shikimic acid was significantly reduced in urine in diabetic rats. The changes in shikimic acid may be due to the alteration of gut microbiota and elevated ROS levels in serum. SN - 2042-650X UR - https://www.unboundmedicine.com/medline/citation/33982735/Diabetes_diminishes_a_typical_metabolite_of_litchi_pericarp_oligomeric_procyanidins__LPOPC__in_urine_mediated_by_imbalanced_gut_microbiota_ DB - PRIME DP - Unbound Medicine ER -