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[Effect of electroacupuncture on serum melatonin and dopamine in aged insomnia].
Zhongguo Zhen Jiu. 2021 May 12; 41(5):501-4.ZZ

Abstract

OBJECTIVE

To observe the clinical effect of electroacupuncture (EA) on aged insomnia, and explore its possible mechanism.

METHODS

A total of 60 patients with aged insomnia were randomly divided into an EA group (30 cases) and a sham EA group (30 cases, 1 case dropped off). The patients in the EA group were treated with acupuncture at Baihui (GV 20), Yintang (GV 29), Shenmen (HT 7), Sanyinjiao (SP 6), Xinshu (BL 15) and Shenshu (BL 23), and EA was used at Baihui (GV 20) and Yintang (GV 29), with intermittent wave, 2 Hz in frequency. In the sham EA group, the acupoints and the EA connection acupoints were the same as those in the EA group, 2-3 mm in depth, but no current was connected. The intervention was given 30 min each time, once every other day, 3 times a week for 4 weeks in the both groups. Before and after treatment, the Pittsburgh sleep quality index (PSQI) and Montreal cognitive assessment (MoCA) scale were used to assess sleep quality and cognitive function, and serum melatonin (MT) and dopamine (DA) levels were detected.

RESULTS

After treatment, the total score and sub-item scores of PSQI in the EA group were lower than those before treatment (P<0.01, P<0.05), among them, the sub-item scores of sleep quality, time to fall asleep, sleep time and sleep efficiency, daytime dysfunction and total score were all lower than those in the sham EA group (P<0.01, P<0.05). After treatment, the MoCA score and serum MT and DA levels in the EA group were higher than those before treatment (P<0.01), and the MoCA score and serum MT level in the EA group were higher than the sham EA group (P<0.01, P<0.05).

CONCLUSION

Electroacupuncture can improve sleep quality and cognitive function in aged insomnia patients, and its mechanism may be related to regulating serum MT and DA levels.

Authors+Show Affiliations

Physical Examination Center, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.Department of Acupuncture- Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.Department of Acupuncture- Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.Department of Acupuncture- Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.Physical Examination Center, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.Department of Acupuncture- Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.Department of Acupuncture- Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.Department of Acupuncture- Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.Department of Acupuncture- Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.Department of Acupuncture- Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.Clinical Laboratory, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

chi

PubMed ID

34002562

Citation

Wang, Xiao-Qiu, et al. "[Effect of Electroacupuncture On Serum Melatonin and Dopamine in Aged Insomnia]." Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, vol. 41, no. 5, 2021, pp. 501-4.
Wang XQ, Qin S, Wu WZ, et al. [Effect of electroacupuncture on serum melatonin and dopamine in aged insomnia]. Zhongguo Zhen Jiu. 2021;41(5):501-4.
Wang, X. Q., Qin, S., Wu, W. Z., Liu, C. Y., Shang, H. T., Wan, Q. Y., Zhao, Y. N., Xi, H. Q., Zheng, S. Y., Li, J. H., & Wang, Y. (2021). [Effect of electroacupuncture on serum melatonin and dopamine in aged insomnia]. Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, 41(5), 501-4. https://doi.org/10.13703/j.0255-2930.20200404-k0001
Wang XQ, et al. [Effect of Electroacupuncture On Serum Melatonin and Dopamine in Aged Insomnia]. Zhongguo Zhen Jiu. 2021 May 12;41(5):501-4. PubMed PMID: 34002562.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of electroacupuncture on serum melatonin and dopamine in aged insomnia]. AU - Wang,Xiao-Qiu, AU - Qin,Shan, AU - Wu,Wen-Zhong, AU - Liu,Cheng-Yong, AU - Shang,Hong-Tao, AU - Wan,Qing-Yun, AU - Zhao,Ya-Nan, AU - Xi,Han-Qing, AU - Zheng,Shi-Yu, AU - Li,Jia-Huan, AU - Wang,Yao, PY - 2021/5/18/entrez PY - 2021/5/19/pubmed PY - 2021/5/20/medline KW - aged insomnia KW - cognitive function KW - dopamine KW - electroacupuncture KW - melatonin KW - randomized controlled trial (RCT) SP - 501 EP - 4 JF - Zhongguo zhen jiu = Chinese acupuncture & moxibustion JO - Zhongguo Zhen Jiu VL - 41 IS - 5 N2 - OBJECTIVE: To observe the clinical effect of electroacupuncture (EA) on aged insomnia, and explore its possible mechanism. METHODS: A total of 60 patients with aged insomnia were randomly divided into an EA group (30 cases) and a sham EA group (30 cases, 1 case dropped off). The patients in the EA group were treated with acupuncture at Baihui (GV 20), Yintang (GV 29), Shenmen (HT 7), Sanyinjiao (SP 6), Xinshu (BL 15) and Shenshu (BL 23), and EA was used at Baihui (GV 20) and Yintang (GV 29), with intermittent wave, 2 Hz in frequency. In the sham EA group, the acupoints and the EA connection acupoints were the same as those in the EA group, 2-3 mm in depth, but no current was connected. The intervention was given 30 min each time, once every other day, 3 times a week for 4 weeks in the both groups. Before and after treatment, the Pittsburgh sleep quality index (PSQI) and Montreal cognitive assessment (MoCA) scale were used to assess sleep quality and cognitive function, and serum melatonin (MT) and dopamine (DA) levels were detected. RESULTS: After treatment, the total score and sub-item scores of PSQI in the EA group were lower than those before treatment (P<0.01, P<0.05), among them, the sub-item scores of sleep quality, time to fall asleep, sleep time and sleep efficiency, daytime dysfunction and total score were all lower than those in the sham EA group (P<0.01, P<0.05). After treatment, the MoCA score and serum MT and DA levels in the EA group were higher than those before treatment (P<0.01), and the MoCA score and serum MT level in the EA group were higher than the sham EA group (P<0.01, P<0.05). CONCLUSION: Electroacupuncture can improve sleep quality and cognitive function in aged insomnia patients, and its mechanism may be related to regulating serum MT and DA levels. SN - 0255-2930 UR - https://www.unboundmedicine.com/medline/citation/34002562/[Effect_of_electroacupuncture_on_serum_melatonin_and_dopamine_in_aged_insomnia]_ L2 - https://medlineplus.gov/insomnia.html DB - PRIME DP - Unbound Medicine ER -