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Differentiating Exudative Macular Degeneration and Polypoidal Choroidal Vasculopathy Using OCT B-Scan.
Ophthalmol Retina. 2021 10; 5(10):954-961.OR

Abstract

PURPOSE

Although polypoidal choroidal vasculopathy (PCV) is best diagnosed with indocyanine green angiography (ICGA), ICGA is often unavailable or not ordered. OCT is widely available, and OCT B-scan can visualize polypoidal lesions diagnostic of PCV as inverted U-shaped elevations of the retinal pigment epithelium (RPE) with heterogeneous reflectivity and sometimes ring-shaped lesions within the polypoidal lesion. This study aims to differentiate findings between eyes diagnosed with PCV or typical exudative age-related macular degeneration (AMD) using ICGA and then compares findings noted on the OCT B-scan line scan in each group.

DESIGN

Retrospective, chart review.

METHODS

Clinical features of eyes with PCV and typical exudative AMD were compared by using ICGA. Eyes with PCV were evaluated for inverted U-shaped polypoidal lesions, which are the main differentiating finding of PCV from typical exudative AMD. Data collected included presence of subretinal fluid (SRF), macular edema or intraretinal edema, subretinal hyperreflective material (SHRM), and retinal pigment epithelial detachment (RPED). These findings were evaluated in 2 parts: baseline and after 6 to 9 months of antiangiogenic therapy. Additionally, analysis was performed for the presence of polypoidal lesions before and after treatment.

MAIN OUTCOME MEASURES

Presence of inverted U-shaped lesions on OCT B-scan following treatment.

RESULTS

A total of 112 eyes of 106 patients were included. A total of 69 eyes were diagnosed with PCV, and 43 eyes were diagnosed with typical exudative AMD. Compared with AMD eyes, PCV eyes had an increased prevalence of SRF at baseline and after 6 to 9 months of treatment, but the prevalence of macular edema, SHRM, and RPED was similar at baseline and at 6 to 9 months after treatment. In PCV eyes, the presence of visible polypoidal lesions decreased from 56.5% to 24.6% after treatment.

CONCLUSIONS

If PCV is suspected in an anti-vascular endothelial growth factor (VEGF)-resistant case of exudative AMD, in the absence of ICGA availability, it is important to look at the baseline OCT B-scan before therapy for evidence of polypoidal lesions. The characteristic inverted U-shaped elevation was present in more than half of PCV eyes on OCT B-scan at baseline but disappeared after antiangiogenic therapy in 56.4% of cases in which this was initially identified. Subretinal fluid was more prevalent in PCV eyes than non-PCV AMD eyes.

Authors+Show Affiliations

Division of Ophthalmology, Department of Surgery, University of Hawaii School of Medicine, Honolulu, Hawaii; University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii; Hawaii Macula and Retina Institute, Aiea, Hawaii; Retina Consultants of Hawaii, Aiea, Hawaii; The Retina Center at Pali Momi, Aiea, Hawaii. Electronic address: retinahi@aol.com.Hawaii Macula and Retina Institute, Aiea, Hawaii; Retina Consultants of Hawaii, Aiea, Hawaii; The Retina Center at Pali Momi, Aiea, Hawaii.University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii; Hawaii Macula and Retina Institute, Aiea, Hawaii; Retina Consultants of Hawaii, Aiea, Hawaii; The Retina Center at Pali Momi, Aiea, Hawaii.University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii; Hawaii Macula and Retina Institute, Aiea, Hawaii; Retina Consultants of Hawaii, Aiea, Hawaii; The Retina Center at Pali Momi, Aiea, Hawaii.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

34022443

Citation

Kokame, Gregg T., et al. "Differentiating Exudative Macular Degeneration and Polypoidal Choroidal Vasculopathy Using OCT B-Scan." Ophthalmology. Retina, vol. 5, no. 10, 2021, pp. 954-961.
Kokame GT, Omizo JN, Kokame KA, et al. Differentiating Exudative Macular Degeneration and Polypoidal Choroidal Vasculopathy Using OCT B-Scan. Ophthalmol Retina. 2021;5(10):954-961.
Kokame, G. T., Omizo, J. N., Kokame, K. A., & Yamane, M. L. (2021). Differentiating Exudative Macular Degeneration and Polypoidal Choroidal Vasculopathy Using OCT B-Scan. Ophthalmology. Retina, 5(10), 954-961. https://doi.org/10.1016/j.oret.2021.05.009
Kokame GT, et al. Differentiating Exudative Macular Degeneration and Polypoidal Choroidal Vasculopathy Using OCT B-Scan. Ophthalmol Retina. 2021;5(10):954-961. PubMed PMID: 34022443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differentiating Exudative Macular Degeneration and Polypoidal Choroidal Vasculopathy Using OCT B-Scan. AU - Kokame,Gregg T, AU - Omizo,Jase N, AU - Kokame,Kelli A, AU - Yamane,Maya L, Y1 - 2021/05/19/ PY - 2021/01/26/received PY - 2021/05/05/revised PY - 2021/05/07/accepted PY - 2021/5/23/pubmed PY - 2022/1/8/medline PY - 2021/5/22/entrez KW - Age-related macular degeneration KW - Anti-VEGF KW - OCT KW - OCT B-scan KW - Polypoidal choroidal vasculopathy SP - 954 EP - 961 JF - Ophthalmology. Retina JO - Ophthalmol Retina VL - 5 IS - 10 N2 - PURPOSE: Although polypoidal choroidal vasculopathy (PCV) is best diagnosed with indocyanine green angiography (ICGA), ICGA is often unavailable or not ordered. OCT is widely available, and OCT B-scan can visualize polypoidal lesions diagnostic of PCV as inverted U-shaped elevations of the retinal pigment epithelium (RPE) with heterogeneous reflectivity and sometimes ring-shaped lesions within the polypoidal lesion. This study aims to differentiate findings between eyes diagnosed with PCV or typical exudative age-related macular degeneration (AMD) using ICGA and then compares findings noted on the OCT B-scan line scan in each group. DESIGN: Retrospective, chart review. METHODS: Clinical features of eyes with PCV and typical exudative AMD were compared by using ICGA. Eyes with PCV were evaluated for inverted U-shaped polypoidal lesions, which are the main differentiating finding of PCV from typical exudative AMD. Data collected included presence of subretinal fluid (SRF), macular edema or intraretinal edema, subretinal hyperreflective material (SHRM), and retinal pigment epithelial detachment (RPED). These findings were evaluated in 2 parts: baseline and after 6 to 9 months of antiangiogenic therapy. Additionally, analysis was performed for the presence of polypoidal lesions before and after treatment. MAIN OUTCOME MEASURES: Presence of inverted U-shaped lesions on OCT B-scan following treatment. RESULTS: A total of 112 eyes of 106 patients were included. A total of 69 eyes were diagnosed with PCV, and 43 eyes were diagnosed with typical exudative AMD. Compared with AMD eyes, PCV eyes had an increased prevalence of SRF at baseline and after 6 to 9 months of treatment, but the prevalence of macular edema, SHRM, and RPED was similar at baseline and at 6 to 9 months after treatment. In PCV eyes, the presence of visible polypoidal lesions decreased from 56.5% to 24.6% after treatment. CONCLUSIONS: If PCV is suspected in an anti-vascular endothelial growth factor (VEGF)-resistant case of exudative AMD, in the absence of ICGA availability, it is important to look at the baseline OCT B-scan before therapy for evidence of polypoidal lesions. The characteristic inverted U-shaped elevation was present in more than half of PCV eyes on OCT B-scan at baseline but disappeared after antiangiogenic therapy in 56.4% of cases in which this was initially identified. Subretinal fluid was more prevalent in PCV eyes than non-PCV AMD eyes. SN - 2468-6530 UR - https://www.unboundmedicine.com/medline/citation/34022443/Differentiating_Exudative_Macular_Degeneration_and_Polypoidal_Choroidal_Vasculopathy_Using_OCT_B_Scan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2468-6530(21)00168-8 DB - PRIME DP - Unbound Medicine ER -