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Evaluation of the therapeutic efficacy of L-carnitine in congestive heart failure.
Int J Clin Pharmacol Ther Toxicol. 1988 Apr; 26(4):217-20.IJ

Abstract

To evaluate the therapeutic efficacy of L-carnitine in elderly subjects suffering from heart failure, secondary to ischemic and/or hypertensive heart disease, 38 patients (22 men, 16 women) were studied, aged from 65 to 82 years. In addition to traditional therapy (digitalis, diuretics, antiarrhythmic agents) given in all cases, 21 patients received oral L-carnitine on the basis of a randomized protocol in 1-g doses twice daily for 45 days (the other 17 received placebo). In the group treated with L-carnitine, a distinct improvement was observed in both subjective and objective conditions; reduced heart rate, edema and dyspnea, increased diuresis and a marked reduction in daily digitalis consumption. L-carnitine treatment also induced a significant reduction in serum cholesterol and triglyceride levels. No adverse reactions attributable to L-carnitine administration were observed in any of the patients.

Authors+Show Affiliations

Reparto Medicina Interna, Ospedale Bussolengo, Verona, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

3403101

Citation

Ghidini, O, et al. "Evaluation of the Therapeutic Efficacy of L-carnitine in Congestive Heart Failure." International Journal of Clinical Pharmacology, Therapy, and Toxicology, vol. 26, no. 4, 1988, pp. 217-20.
Ghidini O, Azzurro M, Vita G, et al. Evaluation of the therapeutic efficacy of L-carnitine in congestive heart failure. Int J Clin Pharmacol Ther Toxicol. 1988;26(4):217-20.
Ghidini, O., Azzurro, M., Vita, G., & Sartori, G. (1988). Evaluation of the therapeutic efficacy of L-carnitine in congestive heart failure. International Journal of Clinical Pharmacology, Therapy, and Toxicology, 26(4), 217-20.
Ghidini O, et al. Evaluation of the Therapeutic Efficacy of L-carnitine in Congestive Heart Failure. Int J Clin Pharmacol Ther Toxicol. 1988;26(4):217-20. PubMed PMID: 3403101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the therapeutic efficacy of L-carnitine in congestive heart failure. AU - Ghidini,O, AU - Azzurro,M, AU - Vita,G, AU - Sartori,G, PY - 1988/4/1/pubmed PY - 1988/4/1/medline PY - 1988/4/1/entrez SP - 217 EP - 20 JF - International journal of clinical pharmacology, therapy, and toxicology JO - Int J Clin Pharmacol Ther Toxicol VL - 26 IS - 4 N2 - To evaluate the therapeutic efficacy of L-carnitine in elderly subjects suffering from heart failure, secondary to ischemic and/or hypertensive heart disease, 38 patients (22 men, 16 women) were studied, aged from 65 to 82 years. In addition to traditional therapy (digitalis, diuretics, antiarrhythmic agents) given in all cases, 21 patients received oral L-carnitine on the basis of a randomized protocol in 1-g doses twice daily for 45 days (the other 17 received placebo). In the group treated with L-carnitine, a distinct improvement was observed in both subjective and objective conditions; reduced heart rate, edema and dyspnea, increased diuresis and a marked reduction in daily digitalis consumption. L-carnitine treatment also induced a significant reduction in serum cholesterol and triglyceride levels. No adverse reactions attributable to L-carnitine administration were observed in any of the patients. SN - 0174-4879 UR - https://www.unboundmedicine.com/medline/citation/3403101/Evaluation_of_the_therapeutic_efficacy_of_L_carnitine_in_congestive_heart_failure_ L2 - https://medlineplus.gov/heartfailure.html DB - PRIME DP - Unbound Medicine ER -