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Association of Candida albicans and Cbp+ Streptococcus mutans with early childhood caries recurrence.
Sci Rep. 2021 05 24; 11(1):10802.SR

Abstract

Early childhood caries (ECC) recurrence occurs in approximately 40% of treated cases within one year. The association of Streptococcus mutans and Candida albicans with the onset of ECC is well known. Also, S. mutans strains harboring collagen-binding proteins (Cbps) avidly bind to collagen-rich dentin and are linked to increased caries risk. Here, we investigated the presence of Cbp+ S. mutans and C. albicans in saliva and dental plaque of children with varying caries statuses, and their salivary microbiome. In this cross-sectional study, 143 children who were caries-free (n = 73), treated for ECC with no signs of recurrence after 6 months (n = 45), or treated for ECC and experiencing recurrence within 6 months following treatment (n = 25) were enrolled. Co-infection with C. albicans and S. mutans, especially Cbp+ S. mutans, was strongly associated with caries recurrence. Subjects of the recurrence group infected with Cbp+ S. mutans showed a greater burden of Candida spp. and of Mutans streptococci in dentin than those infected with Cbp- strains. Salivary microbiome analysis revealed that Streptococcus parasanguinis was overrepresented in the caries recurrence group. Our findings indicate that Cbp+ S. mutans and C. albicans are intimately associated with caries recurrence, contributing to the establishment of recalcitrant biofilms.

Authors+Show Affiliations

Department of Oral Biology, University of Florida College of Dentistry, 1395 Center Drive, PO Box 100424, Gainesville, FL, 32610, USA.Department of Oral Biology, University of Florida College of Dentistry, 1395 Center Drive, PO Box 100424, Gainesville, FL, 32610, USA. San Francisco School of Dentistry, University of California, San Francisco, CA, USA.Department of Community Dentistry and Behavioral Science, University of Florida College of Dentistry, Gainesville, FL, USA. Prevention and Public Health Sciences, University of Illinois at Chicago College of Dentistry, Chicago, IL, USA.Interdisciplinary Research Center On Biotechnology-CIP-Biotec, Universidade Federal Do Pampa, São Gabriel, Rio Grande do Sul, Brazil.Department of Oral Biology, University of Florida College of Dentistry, 1395 Center Drive, PO Box 100424, Gainesville, FL, 32610, USA.Department of Pediatric Dentistry, University of Florida College of Dentistry, Gainesville, FL, USA. Department of Pediatric Dentistry, University of Illinois at Chicago College of Dentistry, Chicago, IL, USA.Department of Oral Biology, University of Florida College of Dentistry, 1395 Center Drive, PO Box 100424, Gainesville, FL, 32610, USA. jabranches@dental.ufl.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

34031498

Citation

Garcia, B A., et al. "Association of Candida Albicans and Cbp+ Streptococcus Mutans With Early Childhood Caries Recurrence." Scientific Reports, vol. 11, no. 1, 2021, p. 10802.
Garcia BA, Acosta NC, Tomar SL, et al. Association of Candida albicans and Cbp+ Streptococcus mutans with early childhood caries recurrence. Sci Rep. 2021;11(1):10802.
Garcia, B. A., Acosta, N. C., Tomar, S. L., Roesch, L. F. W., Lemos, J. A., Mugayar, L. R. F., & Abranches, J. (2021). Association of Candida albicans and Cbp+ Streptococcus mutans with early childhood caries recurrence. Scientific Reports, 11(1), 10802. https://doi.org/10.1038/s41598-021-90198-3
Garcia BA, et al. Association of Candida Albicans and Cbp+ Streptococcus Mutans With Early Childhood Caries Recurrence. Sci Rep. 2021 05 24;11(1):10802. PubMed PMID: 34031498.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of Candida albicans and Cbp+ Streptococcus mutans with early childhood caries recurrence. AU - Garcia,B A, AU - Acosta,N C, AU - Tomar,S L, AU - Roesch,L F W, AU - Lemos,J A, AU - Mugayar,L R F, AU - Abranches,J, Y1 - 2021/05/24/ PY - 2021/03/31/received PY - 2021/05/04/accepted PY - 2021/5/25/entrez PY - 2021/5/26/pubmed PY - 2021/11/6/medline SP - 10802 EP - 10802 JF - Scientific reports JO - Sci Rep VL - 11 IS - 1 N2 - Early childhood caries (ECC) recurrence occurs in approximately 40% of treated cases within one year. The association of Streptococcus mutans and Candida albicans with the onset of ECC is well known. Also, S. mutans strains harboring collagen-binding proteins (Cbps) avidly bind to collagen-rich dentin and are linked to increased caries risk. Here, we investigated the presence of Cbp+ S. mutans and C. albicans in saliva and dental plaque of children with varying caries statuses, and their salivary microbiome. In this cross-sectional study, 143 children who were caries-free (n = 73), treated for ECC with no signs of recurrence after 6 months (n = 45), or treated for ECC and experiencing recurrence within 6 months following treatment (n = 25) were enrolled. Co-infection with C. albicans and S. mutans, especially Cbp+ S. mutans, was strongly associated with caries recurrence. Subjects of the recurrence group infected with Cbp+ S. mutans showed a greater burden of Candida spp. and of Mutans streptococci in dentin than those infected with Cbp- strains. Salivary microbiome analysis revealed that Streptococcus parasanguinis was overrepresented in the caries recurrence group. Our findings indicate that Cbp+ S. mutans and C. albicans are intimately associated with caries recurrence, contributing to the establishment of recalcitrant biofilms. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/34031498/Association_of_Candida_albicans_and_Cbp+_Streptococcus_mutans_with_early_childhood_caries_recurrence_ DB - PRIME DP - Unbound Medicine ER -