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IgA antigliadin antibodies in childhood celiac disease.
Isr J Med Sci. 1988 Jun; 24(6):286-90.IJ

Abstract

Serum IgA-antigliadin antibodies (SAGA) were measured by ELISA in 46 children with proven celiac disease (CD), in 52 children with probable CD, and in 85 control subjects. Small intestinal biopsy was done within 3 months of the SAGA determination in all children. In the proven and probable CD groups, SAGA values were greater than 70 mu/ml in 76 of 82 biopsies that showed severe mucosal damage, but in only 4 of 31 with normal mucosa; thus specificity was 87.1% and sensitivity 92.7%. In the control group, only 12 of 85 children with normal biopsies had a similarly raised SAGA value. SAGA levels decreased significantly when a gluten-free diet was instituted, and rose to abnormal levels in most children on gluten challenge. IgA-SAGA can be used for monitoring dietary compliance during different phases of CD. Although it may help in selecting some children who are evaluated for the possibility of CD, for small intestinal biopsy, children with active CD may show negative SAGA values. The test should therefore not be used as the sole or final determining factor for the performance of small intestinal biopsy. In the proper clinical setting, a biopsy should be done, regardless of the SAGA results.

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Authors+Show Affiliations

Dinari G
Pediatric Gastroenterology Unit, Beilinson Medical Center, Petah Tikva, Israel.
Rosenbach Y
No affiliation info available
Marcus H
No affiliation info available
Nitzan M
No affiliation info available
Zahavi I
No affiliation info available

MeSH

AdolescentAtrophyBiopsyCeliac DiseaseChildChild, PreschoolGliadinHumansImmunoglobulin AInfantIntestinal MucosaIntestine, SmallPlant Proteins

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3403224

Citation

Dinari, G, et al. "IgA Antigliadin Antibodies in Childhood Celiac Disease." Israel Journal of Medical Sciences, vol. 24, no. 6, 1988, pp. 286-90.
Dinari G, Rosenbach Y, Marcus H, et al. IgA antigliadin antibodies in childhood celiac disease. Isr J Med Sci. 1988;24(6):286-90.
Dinari, G., Rosenbach, Y., Marcus, H., Nitzan, M., & Zahavi, I. (1988). IgA antigliadin antibodies in childhood celiac disease. Israel Journal of Medical Sciences, 24(6), 286-90.
Dinari G, et al. IgA Antigliadin Antibodies in Childhood Celiac Disease. Isr J Med Sci. 1988;24(6):286-90. PubMed PMID: 3403224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IgA antigliadin antibodies in childhood celiac disease. AU - Dinari,G, AU - Rosenbach,Y, AU - Marcus,H, AU - Nitzan,M, AU - Zahavi,I, PY - 1988/6/1/pubmed PY - 1988/6/1/medline PY - 1988/6/1/entrez SP - 286 EP - 90 JF - Israel journal of medical sciences JO - Isr J Med Sci VL - 24 IS - 6 N2 - Serum IgA-antigliadin antibodies (SAGA) were measured by ELISA in 46 children with proven celiac disease (CD), in 52 children with probable CD, and in 85 control subjects. Small intestinal biopsy was done within 3 months of the SAGA determination in all children. In the proven and probable CD groups, SAGA values were greater than 70 mu/ml in 76 of 82 biopsies that showed severe mucosal damage, but in only 4 of 31 with normal mucosa; thus specificity was 87.1% and sensitivity 92.7%. In the control group, only 12 of 85 children with normal biopsies had a similarly raised SAGA value. SAGA levels decreased significantly when a gluten-free diet was instituted, and rose to abnormal levels in most children on gluten challenge. IgA-SAGA can be used for monitoring dietary compliance during different phases of CD. Although it may help in selecting some children who are evaluated for the possibility of CD, for small intestinal biopsy, children with active CD may show negative SAGA values. The test should therefore not be used as the sole or final determining factor for the performance of small intestinal biopsy. In the proper clinical setting, a biopsy should be done, regardless of the SAGA results. SN - 0021-2180 UR - https://www.unboundmedicine.com/medline/citation/3403224/IgA_antigliadin_antibodies_in_childhood_celiac_disease_ L2 - https://www.diseaseinfosearch.org/result/1186 DB - PRIME DP - Unbound Medicine ER -