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Neutralization heterogeneity of United Kingdom and South-African SARS-CoV-2 variants in BNT162b2-vaccinated or convalescent COVID-19 healthcare workers.
Clin Infect Dis. 2021 May 29 [Online ahead of print]CI

Abstract

There are concerns about neutralizing antibodies (NAbs) potency against SARS-CoV-2 variants. Despite decreased NAb titers elicited by BNT162b2-vaccine against VOC202012/01 and 501Y.V2 strains, 28/29 healthcare workers (HCW) had a NAb titer ≥1:10. In contrast, six months after COVID-19 mild-forms, only 9/15 (60%) of HCW displayed detectable NAbs against 501Y.V2 strain.

Authors+Show Affiliations

Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié Salpêtrière Hospital, Department of Virology, Paris, France.Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié Salpêtrière Hospital, Department of Virology, Paris, France.Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié Salpêtrière Hospital, Department of Virology, Paris, France.Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié Salpêtrière Hospital, Department of Virology, Paris, France.Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié Salpêtrière Hospital, Department of Virology, Paris, France.Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié Salpêtrière Hospital, Department of Virology, Paris, France.Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié Salpêtrière Hospital, Department of Virology, Paris, France.Department of Virology, Hôpitaux Universitaires Henri Mondor, AP-HP, Créteil, France. Team "Viruses, Hepatology, Cancer", Institut Mondor de Recherche Biomédicale, INSERM U955, Université Paris-Est, Créteil, France.Department of Virology, Hôpitaux Universitaires Henri Mondor, AP-HP, Créteil, France. Team "Viruses, Hepatology, Cancer", Institut Mondor de Recherche Biomédicale, INSERM U955, Université Paris-Est, Créteil, France.Department of Virology, Hôpitaux Universitaires Henri Mondor, AP-HP, Créteil, France. Team "Viruses, Hepatology, Cancer", Institut Mondor de Recherche Biomédicale, INSERM U955, Université Paris-Est, Créteil, France.Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié Salpêtrière Hospital, Department of Virology, Paris, France.Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié Salpêtrière Hospital, Department of Virology, Paris, France.Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié Salpêtrière Hospital, Department of Virology, Paris, France.Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié Salpêtrière Hospital, Department of Virology, Paris, France.Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié Salpêtrière Hospital, Department of Virology, Paris, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34050731

Citation

Marot, Stéphane, et al. "Neutralization Heterogeneity of United Kingdom and South-African SARS-CoV-2 Variants in BNT162b2-vaccinated or Convalescent COVID-19 Healthcare Workers." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 2021.
Marot S, Malet I, Leducq V, et al. Neutralization heterogeneity of United Kingdom and South-African SARS-CoV-2 variants in BNT162b2-vaccinated or convalescent COVID-19 healthcare workers. Clin Infect Dis. 2021.
Marot, S., Malet, I., Leducq, V., Abdi, B., Teyssou, E., Soulie, C., Wirden, M., Rodriguez, C., Fourati, S., Pawlotsky, J. M., Boutolleau, D., Burrel, S., Calvez, V., Marcelin, A. G., & Jary, A. (2021). Neutralization heterogeneity of United Kingdom and South-African SARS-CoV-2 variants in BNT162b2-vaccinated or convalescent COVID-19 healthcare workers. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. https://doi.org/10.1093/cid/ciab492
Marot S, et al. Neutralization Heterogeneity of United Kingdom and South-African SARS-CoV-2 Variants in BNT162b2-vaccinated or Convalescent COVID-19 Healthcare Workers. Clin Infect Dis. 2021 May 29; PubMed PMID: 34050731.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neutralization heterogeneity of United Kingdom and South-African SARS-CoV-2 variants in BNT162b2-vaccinated or convalescent COVID-19 healthcare workers. AU - Marot,Stéphane, AU - Malet,Isabelle, AU - Leducq,Valentin, AU - Abdi,Basma, AU - Teyssou,Elisa, AU - Soulie,Cathia, AU - Wirden,Marc, AU - Rodriguez,Christophe, AU - Fourati,Slim, AU - Pawlotsky,Jean-Michel, AU - Boutolleau,David, AU - Burrel,Sonia, AU - Calvez,Vincent, AU - Marcelin,Anne-Geneviève, AU - Jary,Aude, Y1 - 2021/05/29/ PY - 2021/03/03/received PY - 2021/5/29/entrez PY - 2021/5/30/pubmed PY - 2021/5/30/medline KW - COVID-19 KW - Neutralizing antibodies KW - SARS-CoV-2 variants KW - Vaccine JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis N2 - There are concerns about neutralizing antibodies (NAbs) potency against SARS-CoV-2 variants. Despite decreased NAb titers elicited by BNT162b2-vaccine against VOC202012/01 and 501Y.V2 strains, 28/29 healthcare workers (HCW) had a NAb titer ≥1:10. In contrast, six months after COVID-19 mild-forms, only 9/15 (60%) of HCW displayed detectable NAbs against 501Y.V2 strain. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/34050731/Neutralization_heterogeneity_of_United_Kingdom_and_South_African_SARS_CoV_2_variants_in_BNT162b2_vaccinated_or_convalescent_COVID_19_healthcare_workers_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1093/cid/ciab492 DB - PRIME DP - Unbound Medicine ER -
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