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Toxicity investigation of CeO2 nanoparticles coated with glucose and exopolysaccharides levan and pullulan on the bacterium Vibrio fischeri and aquatic organisms Daphnia magna and Danio rerio.
Aquat Toxicol. 2021 Jul; 236:105867.AT

Abstract

Cerium oxide nanoparticles (nCeO2) have widespread applications, but they can be hazardous to the environment. Some reports indicate the toxic effect of nCeO2 on tested animals, but literature data are mainly contradictory. Coating of nCeO2 can improve their suspension stability and change their interaction with the environment, which can consequently decrease their toxic effects. Herein, the exopolysaccharides levan and pullulan, due to their high water solubility, biocompatibility, and ability to form film, were used to coat nCeO2. Additionally, the monosaccharide glucose was used, since it is a common material for nanoparticle coating. This is the first study investigating the impact of carbohydrate-coated nCeO2 in comparison to uncoated nCeO2 using different model organisms. The aim of this study was to test the acute toxicity of carbohydrate-coated nCeO2 on the bacterium Vibrio fischeri NRRL B-11177, the crustacean Daphnia magna, and zebrafish Danio rerio. The second aim was to investigate the effects of nCeO2 on respiration in Daphnia magna which was performed for the first time. Finally, it was important to see the relation between Ce bioaccumulation in Daphnia magna and Danio rerio and other investigated parameters. Our results revealed that the coating decreased the toxicity of nCeO2 on Vibrio fischeri. The coating of nCeO2 did not affect the nanoparticles' accumulation/adsorption or mortality in Daphnia magna or Danio rerio. Monitoring of respiration in Daphnia magna revealed changes in CO2 production after exposure to coated nCeO2, while the crustacean's O2 consumption was not affected by any of the coated nCeO2. In summary, this study revealed that, at 200 mg L-1, uncoated and carbohydrate-coated nCeO2 are not toxic for the tested organisms, however, the CO2 production in Daphnia magna is different when they are treated with coated and uncoated nCeO2. The highest production was in glucose and levan-coated nCeO2 according to their highest suspension stability. Daphnia magna (D. magna), Danio rerio (D. rerio), Vibrio fischeri (V. fischeri).

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Authors+Show Affiliations

Milenković I
University of Belgrade, Institute for Multidisciplinary Research, Kneza Višeslava 1, 11000 Belgrade, Serbia. Electronic address: ivana.milenkovic@imsi.rs.
Radotić K
University of Belgrade, Institute for Multidisciplinary Research, Kneza Višeslava 1, 11000 Belgrade, Serbia.
Despotović J
University of Belgrade, Institute of Molecular Genetics and Genetic Engineering, Vojvode Stepe 444a, 11010 Belgrade, Serbia.
Lončarević B
University of Belgrade, Institute of Chemistry, Technology and Metallurgy, Njegoševa 12, 11000 Belgrade, Serbia.
Lješević M
University of Belgrade, Institute of Chemistry, Technology and Metallurgy, Njegoševa 12, 11000 Belgrade, Serbia.
Spasić SZ
University of Belgrade, Institute for Multidisciplinary Research, Kneza Višeslava 1, 11000 Belgrade, Serbia; Singidunum University, Danijelova 32, 11010 Belgrade, Serbia.
Nikolić A
University of Belgrade, Institute of Molecular Genetics and Genetic Engineering, Vojvode Stepe 444a, 11010 Belgrade, Serbia.
Beškoski VP
University of Belgrade-Faculty of Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia. Electronic address: vbeskoski@chem.bg.ac.rs.

MeSH

Aliivibrio fischeriAnimalsAquatic OrganismsCeriumDaphniaFructansGlucansGlucoseNanoparticlesWater Pollutants, ChemicalZebrafish

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34052720

Citation

Milenković, Ivana, et al. "Toxicity Investigation of CeO2 Nanoparticles Coated With Glucose and Exopolysaccharides Levan and Pullulan On the Bacterium Vibrio Fischeri and Aquatic Organisms Daphnia Magna and Danio Rerio." Aquatic Toxicology (Amsterdam, Netherlands), vol. 236, 2021, p. 105867.
Milenković I, Radotić K, Despotović J, et al. Toxicity investigation of CeO2 nanoparticles coated with glucose and exopolysaccharides levan and pullulan on the bacterium Vibrio fischeri and aquatic organisms Daphnia magna and Danio rerio. Aquat Toxicol. 2021;236:105867.
Milenković, I., Radotić, K., Despotović, J., Lončarević, B., Lješević, M., Spasić, S. Z., Nikolić, A., & Beškoski, V. P. (2021). Toxicity investigation of CeO2 nanoparticles coated with glucose and exopolysaccharides levan and pullulan on the bacterium Vibrio fischeri and aquatic organisms Daphnia magna and Danio rerio. Aquatic Toxicology (Amsterdam, Netherlands), 236, 105867. https://doi.org/10.1016/j.aquatox.2021.105867
Milenković I, et al. Toxicity Investigation of CeO2 Nanoparticles Coated With Glucose and Exopolysaccharides Levan and Pullulan On the Bacterium Vibrio Fischeri and Aquatic Organisms Daphnia Magna and Danio Rerio. Aquat Toxicol. 2021;236:105867. PubMed PMID: 34052720.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toxicity investigation of CeO2 nanoparticles coated with glucose and exopolysaccharides levan and pullulan on the bacterium Vibrio fischeri and aquatic organisms Daphnia magna and Danio rerio. AU - Milenković,Ivana, AU - Radotić,Ksenija, AU - Despotović,Jovana, AU - Lončarević,Branka, AU - Lješević,Marija, AU - Spasić,Slađana Z, AU - Nikolić,Aleksandra, AU - Beškoski,Vladimir P, Y1 - 2021/05/16/ PY - 2021/01/31/received PY - 2021/04/19/revised PY - 2021/05/10/accepted PY - 2021/5/31/pubmed PY - 2021/6/23/medline PY - 2021/5/30/entrez KW - CeO(2) KW - Coating KW - Danio rerio KW - Daphnia magna KW - Nanoparticles. KW - Vibrio fischeri SP - 105867 EP - 105867 JF - Aquatic toxicology (Amsterdam, Netherlands) JO - Aquat Toxicol VL - 236 N2 - Cerium oxide nanoparticles (nCeO2) have widespread applications, but they can be hazardous to the environment. Some reports indicate the toxic effect of nCeO2 on tested animals, but literature data are mainly contradictory. Coating of nCeO2 can improve their suspension stability and change their interaction with the environment, which can consequently decrease their toxic effects. Herein, the exopolysaccharides levan and pullulan, due to their high water solubility, biocompatibility, and ability to form film, were used to coat nCeO2. Additionally, the monosaccharide glucose was used, since it is a common material for nanoparticle coating. This is the first study investigating the impact of carbohydrate-coated nCeO2 in comparison to uncoated nCeO2 using different model organisms. The aim of this study was to test the acute toxicity of carbohydrate-coated nCeO2 on the bacterium Vibrio fischeri NRRL B-11177, the crustacean Daphnia magna, and zebrafish Danio rerio. The second aim was to investigate the effects of nCeO2 on respiration in Daphnia magna which was performed for the first time. Finally, it was important to see the relation between Ce bioaccumulation in Daphnia magna and Danio rerio and other investigated parameters. Our results revealed that the coating decreased the toxicity of nCeO2 on Vibrio fischeri. The coating of nCeO2 did not affect the nanoparticles' accumulation/adsorption or mortality in Daphnia magna or Danio rerio. Monitoring of respiration in Daphnia magna revealed changes in CO2 production after exposure to coated nCeO2, while the crustacean's O2 consumption was not affected by any of the coated nCeO2. In summary, this study revealed that, at 200 mg L-1, uncoated and carbohydrate-coated nCeO2 are not toxic for the tested organisms, however, the CO2 production in Daphnia magna is different when they are treated with coated and uncoated nCeO2. The highest production was in glucose and levan-coated nCeO2 according to their highest suspension stability. Daphnia magna (D. magna), Danio rerio (D. rerio), Vibrio fischeri (V. fischeri). SN - 1879-1514 UR - https://www.unboundmedicine.com/medline/citation/34052720/Toxicity_investigation_of_CeO2_nanoparticles_coated_with_glucose_and_exopolysaccharides_levan_and_pullulan_on_the_bacterium_Vibrio_fischeri_and_aquatic_organisms_Daphnia_magna_and_Danio_rerio_ DB - PRIME DP - Unbound Medicine ER -