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Diagnostic and Therapeutic Potential of Exosomal MicroRNAs for Neurodegenerative Diseases.
Neural Plast. 2021; 2021:8884642.NP

Abstract

Neurodegenerative disorders (NDs) are characterized by a gradual loss of neurons and functions that eventually leads to progressive neurological impairment. In view of the heavy burden on the healthcare system, efficient and reliable biomarkers for early diagnosis and therapeutic treatments to reverse the progression of NDs are in urgent need. There has been an increasing interest in using exosomal miRNAs as biomarkers or targeted therapies for neurological diseases recently. In this review, we overviewed the updated studies on exosomal miRNAs as biomarkers and potential therapeutic approaches in NDs, as well as their association with the pathophysiology of this group of disorders, especially Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD). The exosomal miRNAs that are commonly dysregulated across different NDs or are commonly used as therapeutic candidates were also identified and summarized. In summary, the feasibility of exosomal miRNAs as biomarkers and potential targeted therapy for NDs has been verified. However, due to the limitations of existing studies and the discrepancies across different studies, high quality laboratory and clinical investigations are still required.

Authors+Show Affiliations

Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, 410011 Hunan, China.Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, 410011 Hunan, China.Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, 410011 Hunan, China.Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, China. National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

34054944

Citation

He, Miao, et al. "Diagnostic and Therapeutic Potential of Exosomal MicroRNAs for Neurodegenerative Diseases." Neural Plasticity, vol. 2021, 2021, p. 8884642.
He M, Zhang HN, Tang ZC, et al. Diagnostic and Therapeutic Potential of Exosomal MicroRNAs for Neurodegenerative Diseases. Neural Plast. 2021;2021:8884642.
He, M., Zhang, H. N., Tang, Z. C., & Gao, S. G. (2021). Diagnostic and Therapeutic Potential of Exosomal MicroRNAs for Neurodegenerative Diseases. Neural Plasticity, 2021, 8884642. https://doi.org/10.1155/2021/8884642
He M, et al. Diagnostic and Therapeutic Potential of Exosomal MicroRNAs for Neurodegenerative Diseases. Neural Plast. 2021;2021:8884642. PubMed PMID: 34054944.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic and Therapeutic Potential of Exosomal MicroRNAs for Neurodegenerative Diseases. AU - He,Miao, AU - Zhang,Hai-Nan, AU - Tang,Zhen-Chu, AU - Gao,Shu-Guang, Y1 - 2021/05/16/ PY - 2020/10/07/received PY - 2021/05/11/accepted PY - 2021/5/31/entrez PY - 2021/6/1/pubmed PY - 2021/12/15/medline SP - 8884642 EP - 8884642 JF - Neural plasticity JO - Neural Plast VL - 2021 N2 - Neurodegenerative disorders (NDs) are characterized by a gradual loss of neurons and functions that eventually leads to progressive neurological impairment. In view of the heavy burden on the healthcare system, efficient and reliable biomarkers for early diagnosis and therapeutic treatments to reverse the progression of NDs are in urgent need. There has been an increasing interest in using exosomal miRNAs as biomarkers or targeted therapies for neurological diseases recently. In this review, we overviewed the updated studies on exosomal miRNAs as biomarkers and potential therapeutic approaches in NDs, as well as their association with the pathophysiology of this group of disorders, especially Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD). The exosomal miRNAs that are commonly dysregulated across different NDs or are commonly used as therapeutic candidates were also identified and summarized. In summary, the feasibility of exosomal miRNAs as biomarkers and potential targeted therapy for NDs has been verified. However, due to the limitations of existing studies and the discrepancies across different studies, high quality laboratory and clinical investigations are still required. SN - 1687-5443 UR - https://www.unboundmedicine.com/medline/citation/34054944/Diagnostic_and_Therapeutic_Potential_of_Exosomal_MicroRNAs_for_Neurodegenerative_Diseases_ DB - PRIME DP - Unbound Medicine ER -