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Interplay of RNA-Binding Proteins and microRNAs in Neurodegenerative Diseases.
Int J Mol Sci. 2021 May 18; 22(10)IJ

Abstract

The number of patients with neurodegenerative diseases (NDs) is increasing, along with the growing number of older adults. This escalation threatens to create a medical and social crisis. NDs include a large spectrum of heterogeneous and multifactorial pathologies, such as amyotrophic lateral sclerosis, frontotemporal dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease and multiple system atrophy, and the formation of inclusion bodies resulting from protein misfolding and aggregation is a hallmark of these disorders. The proteinaceous components of the pathological inclusions include several RNA-binding proteins (RBPs), which play important roles in splicing, stability, transcription and translation. In addition, RBPs were shown to play a critical role in regulating miRNA biogenesis and metabolism. The dysfunction of both RBPs and miRNAs is often observed in several NDs. Thus, the data about the interplay among RBPs and miRNAs and their cooperation in brain functions would be important to know for better understanding NDs and the development of effective therapeutics. In this review, we focused on the connection between miRNAs, RBPs and neurodegenerative diseases.

Authors+Show Affiliations

Department of Pharmacology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan.Department of Pharmacology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan. Teikyo University Support Center for Women Physicians and Researchers, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan.Department of Pharmacology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

34069857

Citation

Kinoshita, Chisato, et al. "Interplay of RNA-Binding Proteins and microRNAs in Neurodegenerative Diseases." International Journal of Molecular Sciences, vol. 22, no. 10, 2021.
Kinoshita C, Kubota N, Aoyama K. Interplay of RNA-Binding Proteins and microRNAs in Neurodegenerative Diseases. Int J Mol Sci. 2021;22(10).
Kinoshita, C., Kubota, N., & Aoyama, K. (2021). Interplay of RNA-Binding Proteins and microRNAs in Neurodegenerative Diseases. International Journal of Molecular Sciences, 22(10). https://doi.org/10.3390/ijms22105292
Kinoshita C, Kubota N, Aoyama K. Interplay of RNA-Binding Proteins and microRNAs in Neurodegenerative Diseases. Int J Mol Sci. 2021 May 18;22(10) PubMed PMID: 34069857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interplay of RNA-Binding Proteins and microRNAs in Neurodegenerative Diseases. AU - Kinoshita,Chisato, AU - Kubota,Noriko, AU - Aoyama,Koji, Y1 - 2021/05/18/ PY - 2021/04/30/received PY - 2021/05/14/revised PY - 2021/05/15/accepted PY - 2021/6/2/entrez PY - 2021/6/3/pubmed PY - 2021/6/24/medline KW - RNA-binding protein KW - microRNA KW - neurodegenerative disease JF - International journal of molecular sciences JO - Int J Mol Sci VL - 22 IS - 10 N2 - The number of patients with neurodegenerative diseases (NDs) is increasing, along with the growing number of older adults. This escalation threatens to create a medical and social crisis. NDs include a large spectrum of heterogeneous and multifactorial pathologies, such as amyotrophic lateral sclerosis, frontotemporal dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease and multiple system atrophy, and the formation of inclusion bodies resulting from protein misfolding and aggregation is a hallmark of these disorders. The proteinaceous components of the pathological inclusions include several RNA-binding proteins (RBPs), which play important roles in splicing, stability, transcription and translation. In addition, RBPs were shown to play a critical role in regulating miRNA biogenesis and metabolism. The dysfunction of both RBPs and miRNAs is often observed in several NDs. Thus, the data about the interplay among RBPs and miRNAs and their cooperation in brain functions would be important to know for better understanding NDs and the development of effective therapeutics. In this review, we focused on the connection between miRNAs, RBPs and neurodegenerative diseases. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/34069857/Interplay_of_RNA_Binding_Proteins_and_microRNAs_in_Neurodegenerative_Diseases_ DB - PRIME DP - Unbound Medicine ER -