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Physical Exercise-Induced Myokines in Neurodegenerative Diseases.
Int J Mol Sci. 2021 May 28; 22(11)IJ

Abstract

Neurodegenerative diseases (NDs), such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), are disorders characterized by progressive degeneration of the nervous system. Currently, there is no disease-modifying treatments for most NDs. Meanwhile, numerous studies conducted on human and animal models over the past decades have showed that exercises had beneficial effects on NDs. Inter-tissue communication by myokine, a peptide produced and secreted by skeletal muscles during exercise, is thought to be an important underlying mechanism for the advantages. Here, we reviewed studies about the effects of myokines regulated by exercise on NDs and their mechanisms. Myokines could exert beneficial effects on NDs through a variety of regulatory mechanisms, including cell survival, neurogenesis, neuroinflammation, proteostasis, oxidative stress, and protein modification. Studies on exercise-induced myokines are expected to provide a novel strategy for treating NDs, for which there are no adequate treatments nowadays. To date, only a few myokines have been investigated for their effects on NDs and studies on mechanisms involved in them are in their infancy. Therefore, future studies are needed to discover more myokines and test their effects on NDs.

Authors+Show Affiliations

Department of Biological Sciences, Konkuk University, Seoul 05029, Korea.Department of Biological Sciences, Konkuk University, Seoul 05029, Korea.Department of Biological Sciences, Konkuk University, Seoul 05029, Korea.Department of Biological Sciences, Konkuk University, Seoul 05029, Korea. Korea Hemp Institute, Konkuk University, Seoul 05029, Korea.Department of Biological Sciences, Konkuk University, Seoul 05029, Korea. Korea Hemp Institute, Konkuk University, Seoul 05029, Korea.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

34071457

Citation

Lee, Banseok, et al. "Physical Exercise-Induced Myokines in Neurodegenerative Diseases." International Journal of Molecular Sciences, vol. 22, no. 11, 2021.
Lee B, Shin M, Park Y, et al. Physical Exercise-Induced Myokines in Neurodegenerative Diseases. Int J Mol Sci. 2021;22(11).
Lee, B., Shin, M., Park, Y., Won, S. Y., & Cho, K. S. (2021). Physical Exercise-Induced Myokines in Neurodegenerative Diseases. International Journal of Molecular Sciences, 22(11). https://doi.org/10.3390/ijms22115795
Lee B, et al. Physical Exercise-Induced Myokines in Neurodegenerative Diseases. Int J Mol Sci. 2021 May 28;22(11) PubMed PMID: 34071457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physical Exercise-Induced Myokines in Neurodegenerative Diseases. AU - Lee,Banseok, AU - Shin,Myeongcheol, AU - Park,Youngjae, AU - Won,So-Yoon, AU - Cho,Kyoung Sang, Y1 - 2021/05/28/ PY - 2021/04/19/received PY - 2021/05/24/revised PY - 2021/05/25/accepted PY - 2021/6/2/entrez PY - 2021/6/3/pubmed PY - 2021/6/22/medline KW - Alzheimer’s disease KW - Huntington’s disease KW - Parkinson’s disease KW - amyotrophic lateral sclerosis KW - exercise KW - muscle–brain axis KW - myokines KW - neurodegenerative diseases JF - International journal of molecular sciences JO - Int J Mol Sci VL - 22 IS - 11 N2 - Neurodegenerative diseases (NDs), such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), are disorders characterized by progressive degeneration of the nervous system. Currently, there is no disease-modifying treatments for most NDs. Meanwhile, numerous studies conducted on human and animal models over the past decades have showed that exercises had beneficial effects on NDs. Inter-tissue communication by myokine, a peptide produced and secreted by skeletal muscles during exercise, is thought to be an important underlying mechanism for the advantages. Here, we reviewed studies about the effects of myokines regulated by exercise on NDs and their mechanisms. Myokines could exert beneficial effects on NDs through a variety of regulatory mechanisms, including cell survival, neurogenesis, neuroinflammation, proteostasis, oxidative stress, and protein modification. Studies on exercise-induced myokines are expected to provide a novel strategy for treating NDs, for which there are no adequate treatments nowadays. To date, only a few myokines have been investigated for their effects on NDs and studies on mechanisms involved in them are in their infancy. Therefore, future studies are needed to discover more myokines and test their effects on NDs. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/34071457/Physical_Exercise_Induced_Myokines_in_Neurodegenerative_Diseases_ L2 - https://www.mdpi.com/resolver?pii=ijms22115795 DB - PRIME DP - Unbound Medicine ER -