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Preparation of serum capped silver nanoparticles for selective killing of microbial cells sparing host cells.
Sci Rep. 2021 06 02; 11(1):11610.SR

Abstract

Following access into the cell, colloidal silver nanoparticles exhibit generalized cytotoxic properties, thus appear as omnipotent microbicidal, but not suitable for systemic use unless are free of toxic effects on host cells. The AgNP-Serum-18 when prepared from silver nitrate, using dextrose as reducing and group-matched homologous serum as a stabilizing agent, selective endocytosis, and oxidative stress-dependent bio-functional damages to the host are mostly eliminated. For their bio-mimicking outer coat, there is the least possibility of internalization into host cells or liberation of excess oxidants in circulation following interaction with erythrocytes or vascular endothelial cells. The presence of infection-specific antibodies in the serum can make such nano-conjugates more selective. A potent antimicrobial action and a wide margin of safety for mammalian cells in comparison with very similar PVA-capped silver nanoparticles have been demonstrated by the in-vitro challenge of such nanoparticles on different microbes, human liver cell-line, and in-vivo study on mice model. This may open up wide-range therapeutic prospects of colloidal nanoparticles.

Authors+Show Affiliations

Department of Microbiology, Institute of Post-Graduate Medical Education and Research, Calcutta, 700020, India. rehanaparveen20july@gmail.com.Department of Microbiology, Institute of Post-Graduate Medical Education and Research, Calcutta, 700020, India.Department of Signal Transduction and Biogenic Amines, Chittaranjan National Cancer Institute, Calcutta, 700026, India.Advanced Mechanical and Materials Characterization Division, CSIR-Central Glass and Ceramic Research Institute, Calcutta, 700 032, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34078983

Citation

Parveen, Rehana, et al. "Preparation of Serum Capped Silver Nanoparticles for Selective Killing of Microbial Cells Sparing Host Cells." Scientific Reports, vol. 11, no. 1, 2021, p. 11610.
Parveen R, Maiti PK, Murmu N, et al. Preparation of serum capped silver nanoparticles for selective killing of microbial cells sparing host cells. Sci Rep. 2021;11(1):11610.
Parveen, R., Maiti, P. K., Murmu, N., & Datta, A. (2021). Preparation of serum capped silver nanoparticles for selective killing of microbial cells sparing host cells. Scientific Reports, 11(1), 11610. https://doi.org/10.1038/s41598-021-91031-7
Parveen R, et al. Preparation of Serum Capped Silver Nanoparticles for Selective Killing of Microbial Cells Sparing Host Cells. Sci Rep. 2021 06 2;11(1):11610. PubMed PMID: 34078983.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation of serum capped silver nanoparticles for selective killing of microbial cells sparing host cells. AU - Parveen,Rehana, AU - Maiti,Prasanta Kumar, AU - Murmu,Nabendu, AU - Datta,Alokmay, Y1 - 2021/06/02/ PY - 2021/02/12/received PY - 2021/05/20/accepted PY - 2021/6/3/entrez PY - 2021/6/4/pubmed PY - 2021/6/4/medline SP - 11610 EP - 11610 JF - Scientific reports JO - Sci Rep VL - 11 IS - 1 N2 - Following access into the cell, colloidal silver nanoparticles exhibit generalized cytotoxic properties, thus appear as omnipotent microbicidal, but not suitable for systemic use unless are free of toxic effects on host cells. The AgNP-Serum-18 when prepared from silver nitrate, using dextrose as reducing and group-matched homologous serum as a stabilizing agent, selective endocytosis, and oxidative stress-dependent bio-functional damages to the host are mostly eliminated. For their bio-mimicking outer coat, there is the least possibility of internalization into host cells or liberation of excess oxidants in circulation following interaction with erythrocytes or vascular endothelial cells. The presence of infection-specific antibodies in the serum can make such nano-conjugates more selective. A potent antimicrobial action and a wide margin of safety for mammalian cells in comparison with very similar PVA-capped silver nanoparticles have been demonstrated by the in-vitro challenge of such nanoparticles on different microbes, human liver cell-line, and in-vivo study on mice model. This may open up wide-range therapeutic prospects of colloidal nanoparticles. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/34078983/Preparation_of_serum_capped_silver_nanoparticles_for_selective_killing_of_microbial_cells_sparing_host_cells. L2 - https://doi.org/10.1038/s41598-021-91031-7 DB - PRIME DP - Unbound Medicine ER -
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