Tags

Type your tag names separated by a space and hit enter

COVID-19 Severity and COVID-19-Associated Deaths Among Hospitalized Patients with HIV Infection - Zambia, March-December 2020.
MMWR Morb Mortal Wkly Rep. 2021 Jun 04; 70(22):807-810.MM

Abstract

The effect of HIV infection on COVID-19 outcomes is unclear. Studies in South Africa (1) and the United Kingdom (2) found an independent association between HIV infection and COVID-19 mortality; however, other studies have not found an association between poor COVID-19 outcomes and either HIV status among hospitalized patients (3-5) or HIV-associated factors such as CD4 count, viral load, or type of antiretroviral therapy (ART) (6). The effect of HIV infection on COVID-19 outcomes remains an urgent question in sub-Saharan Africa, where many countries are experiencing dual HIV and COVID-19 epidemics, and capacity to treat severe COVID-19 is limited. Using data from patients with probable or confirmed COVID-19 admitted to specialized treatment centers during March-December 2020 in Zambia, the Zambian Ministry of Health and CDC assessed the relationship between HIV infection and severe COVID-19 and COVID-19-associated death. Among 443 patients included in the study, 122 (28%) were HIV-positive, and of these, 91 (89%) were receiving ART at the time of hospitalization. HIV status alone was not significantly associated with severe COVID-19 at admission or during hospitalization or with COVID-19-associated death. However, among HIV-positive persons, those with severe HIV disease were more likely to develop severe COVID-19 and were at increased risk for COVID-19-associated death. Ensuring that persons maintain HIV disease control, including maintaining ART continuity and adherence, achieving viral suppression, and addressing and managing underlying medical conditions, could help reduce COVID-19-associated morbidity and mortality in sub-Saharan Africa.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34081684

Citation

Chanda, Duncan, et al. "COVID-19 Severity and COVID-19-Associated Deaths Among Hospitalized Patients With HIV Infection - Zambia, March-December 2020." MMWR. Morbidity and Mortality Weekly Report, vol. 70, no. 22, 2021, pp. 807-810.
Chanda D, Minchella PA, Kampamba D, et al. COVID-19 Severity and COVID-19-Associated Deaths Among Hospitalized Patients with HIV Infection - Zambia, March-December 2020. MMWR Morb Mortal Wkly Rep. 2021;70(22):807-810.
Chanda, D., Minchella, P. A., Kampamba, D., Itoh, M., Hines, J. Z., Fwoloshi, S., Boyd, M. A., Hamusonde, K., Chirwa, L., Nikoi, K., Chirwa, R., Siwingwa, M., Sivile, S., Zyambo, K. D., Mweemba, A., Mbewe, N., Mutengo, K. H., Malama, K., Agolory, S., & Mulenga, L. B. (2021). COVID-19 Severity and COVID-19-Associated Deaths Among Hospitalized Patients with HIV Infection - Zambia, March-December 2020. MMWR. Morbidity and Mortality Weekly Report, 70(22), 807-810. https://doi.org/10.15585/mmwr.mm7022a2
Chanda D, et al. COVID-19 Severity and COVID-19-Associated Deaths Among Hospitalized Patients With HIV Infection - Zambia, March-December 2020. MMWR Morb Mortal Wkly Rep. 2021 Jun 4;70(22):807-810. PubMed PMID: 34081684.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COVID-19 Severity and COVID-19-Associated Deaths Among Hospitalized Patients with HIV Infection - Zambia, March-December 2020. AU - Chanda,Duncan, AU - Minchella,Peter A, AU - Kampamba,Davies, AU - Itoh,Megumi, AU - Hines,Jonas Z, AU - Fwoloshi,Sombo, AU - Boyd,Mary Adetinuke, AU - Hamusonde,Kalongo, AU - Chirwa,Lameck, AU - Nikoi,Kotey, AU - Chirwa,Robert, AU - Siwingwa,Mpanji, AU - Sivile,Suilanji, AU - Zyambo,Khozya D, AU - Mweemba,Aggrey, AU - Mbewe,Nyuma, AU - Mutengo,Katongo H, AU - Malama,Kennedy, AU - Agolory,Simon, AU - Mulenga,Lloyd B, Y1 - 2021/06/04/ PY - 2021/6/3/entrez PY - 2021/6/4/pubmed PY - 2021/6/5/medline SP - 807 EP - 810 JF - MMWR. Morbidity and mortality weekly report JO - MMWR Morb Mortal Wkly Rep VL - 70 IS - 22 N2 - The effect of HIV infection on COVID-19 outcomes is unclear. Studies in South Africa (1) and the United Kingdom (2) found an independent association between HIV infection and COVID-19 mortality; however, other studies have not found an association between poor COVID-19 outcomes and either HIV status among hospitalized patients (3-5) or HIV-associated factors such as CD4 count, viral load, or type of antiretroviral therapy (ART) (6). The effect of HIV infection on COVID-19 outcomes remains an urgent question in sub-Saharan Africa, where many countries are experiencing dual HIV and COVID-19 epidemics, and capacity to treat severe COVID-19 is limited. Using data from patients with probable or confirmed COVID-19 admitted to specialized treatment centers during March-December 2020 in Zambia, the Zambian Ministry of Health and CDC assessed the relationship between HIV infection and severe COVID-19 and COVID-19-associated death. Among 443 patients included in the study, 122 (28%) were HIV-positive, and of these, 91 (89%) were receiving ART at the time of hospitalization. HIV status alone was not significantly associated with severe COVID-19 at admission or during hospitalization or with COVID-19-associated death. However, among HIV-positive persons, those with severe HIV disease were more likely to develop severe COVID-19 and were at increased risk for COVID-19-associated death. Ensuring that persons maintain HIV disease control, including maintaining ART continuity and adherence, achieving viral suppression, and addressing and managing underlying medical conditions, could help reduce COVID-19-associated morbidity and mortality in sub-Saharan Africa. SN - 1545-861X UR - https://www.unboundmedicine.com/medline/citation/34081684/COVID-19_Severity_and_COVID-19-Associated_Deaths_Among_Hospitalized_Patients_with_HIV_Infection_-_Zambia,_March-December_2020. L2 - https://doi.org/10.15585/mmwr.mm7022a2 DB - PRIME DP - Unbound Medicine ER -