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SARS-CoV2 spike protein gene variants with N501T and G142D mutation-dominated infections in mink in the United States.
J Vet Diagn Invest. 2021 Sep; 33(5):939-942.JV

Abstract

Large numbers of mink have been infected with SARS-CoV2 containing the spike protein Y453F mutation in Europe, causing zoonosis concerns. To evaluate the genetic characteristics of the U.S. and Canadian mink-derived SARS-CoV2 sequences, we analyzed all animal-derived (977) and all Canadian (19,529) and U.S. (173,277) SARS-CoV2 sequences deposited in GISAID from December 2019 to March 12, 2021, and identified 2 dominant novel variants, the N501T-G142D variant and N501T-G142D-F486L variant, in the U.S. mink-derived SARS-CoV2 sequences. These variants were not found in mink from Canada or other countries. The Y453F mutation was not identified in the mink-derived sequences in the United States and Canada. The N501T mutation occurred 2 mo earlier in humans than in mink in the United States, and the novel N501T-G142D and N501T-G142D-F486L variants were found in humans prior to mink. Our results suggest that the novel SARS-CoV2 variants may have evolved during human infection and were then transmitted to mink populations in the United States.

Authors+Show Affiliations

Animal Health Laboratory, University of Guelph, Guelph, Ontario, Canada.Faculty of Science, University of British Colombia, BC, Canada.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34109885

Citation

Cai, Hugh Y., and Allison Cai. "SARS-CoV2 Spike Protein Gene Variants With N501T and G142D Mutation-dominated Infections in Mink in the United States." Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, vol. 33, no. 5, 2021, pp. 939-942.
Cai HY, Cai A. SARS-CoV2 spike protein gene variants with N501T and G142D mutation-dominated infections in mink in the United States. J Vet Diagn Invest. 2021;33(5):939-942.
Cai, H. Y., & Cai, A. (2021). SARS-CoV2 spike protein gene variants with N501T and G142D mutation-dominated infections in mink in the United States. Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 33(5), 939-942. https://doi.org/10.1177/10406387211023481
Cai HY, Cai A. SARS-CoV2 Spike Protein Gene Variants With N501T and G142D Mutation-dominated Infections in Mink in the United States. J Vet Diagn Invest. 2021;33(5):939-942. PubMed PMID: 34109885.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SARS-CoV2 spike protein gene variants with N501T and G142D mutation-dominated infections in mink in the United States. AU - Cai,Hugh Y, AU - Cai,Allison, Y1 - 2021/06/10/ PY - 2021/6/11/pubmed PY - 2021/9/9/medline PY - 2021/6/10/entrez KW - COVID-19 KW - N501T KW - N501Y KW - SARS-CoV2 KW - mink KW - spike protein KW - variant SP - 939 EP - 942 JF - Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc JO - J Vet Diagn Invest VL - 33 IS - 5 N2 - Large numbers of mink have been infected with SARS-CoV2 containing the spike protein Y453F mutation in Europe, causing zoonosis concerns. To evaluate the genetic characteristics of the U.S. and Canadian mink-derived SARS-CoV2 sequences, we analyzed all animal-derived (977) and all Canadian (19,529) and U.S. (173,277) SARS-CoV2 sequences deposited in GISAID from December 2019 to March 12, 2021, and identified 2 dominant novel variants, the N501T-G142D variant and N501T-G142D-F486L variant, in the U.S. mink-derived SARS-CoV2 sequences. These variants were not found in mink from Canada or other countries. The Y453F mutation was not identified in the mink-derived sequences in the United States and Canada. The N501T mutation occurred 2 mo earlier in humans than in mink in the United States, and the novel N501T-G142D and N501T-G142D-F486L variants were found in humans prior to mink. Our results suggest that the novel SARS-CoV2 variants may have evolved during human infection and were then transmitted to mink populations in the United States. SN - 1943-4936 UR - https://www.unboundmedicine.com/medline/citation/34109885/SARS_CoV2_spike_protein_gene_variants_with_N501T_and_G142D_mutation_dominated_infections_in_mink_in_the_United_States_ DB - PRIME DP - Unbound Medicine ER -