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Coffee consumption and cardiovascular diseases and mortality in patients with type 2 diabetes: A systematic review and dose-response meta-analysis of cohort studies.
Nutr Metab Cardiovasc Dis. 2021 08 26; 31(9):2526-2538.NM

Abstract

AIMS

To evaluate the long-term consequences of coffee drinking in patients with type 2 diabetes.

DATA SYNTHESIS

PubMed, Scopus, and Web of Sciences were searched to November 2020 for prospective cohort studies evaluating the association of coffee drinking with risk of cardiovascular disease (CVD) and mortality in patients with type 2 diabetes. Two reviewers extracted data and rated the certainty of evidence using GRADE approach. Random-effects models were used to estimate the hazard ratios (HRs) and 95% CIs. Dose-response associations were modeled by a one-stage mixed-effects meta-analysis. Ten prospective cohort studies with 82,270 cases were included. Compared to those with no coffee consumption, the HRs for consumption of 4 cups/d were 0.79 (95%CI: 0.72, 0.87; n = 10 studies) for all-cause mortality, 0.60 (95%CI: 0.46, 0.79; n = 4) for CVD mortality, 0.68 (95%CI: 0.51, 0.91; n = 3) for coronary heart disease (CHD) mortality, 0.72 (95%CI: 0.54, 0.98; n = 2) for CHD, and 0.77 (95%CI: 0.61, 0.98; n = 2) for total CVD events. There was no significant association for cancer mortality and stroke. There was an inverse monotonic association between coffee drinking and all-cause and CVD mortality, and inverse linear association for CHD and total CVD events. The certainty of evidence was graded moderate for all-cause mortality, and low or very low for other outcomes.

CONCLUSIONS

Drinking coffee may be inversely associated with the risk of mortality in patients with type 2 diabetes. However, more research is needed considering type of coffee, sugar and cream added to coffee, and history of CVD to present more confident results.

REGISTRY AND REGISTRY NUMBER

The protocol of this systematic review was registered at Open Science Framework (https://osf.io/8uaf3, registered form: osf.io/xur76, registration DOI: 10.17605/OSF.IO/8UAF3).

Authors+Show Affiliations

Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.Food Safety Research Center (salt), Semnan University of Medical Siences, Semnan, Iran.Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada.Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Electronic address: s_shabbidar@tums.ac.ir.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

34112583

Citation

Shahinfar, Hossein, et al. "Coffee Consumption and Cardiovascular Diseases and Mortality in Patients With Type 2 Diabetes: a Systematic Review and Dose-response Meta-analysis of Cohort Studies." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 31, no. 9, 2021, pp. 2526-2538.
Shahinfar H, Jayedi A, Khan TA, et al. Coffee consumption and cardiovascular diseases and mortality in patients with type 2 diabetes: A systematic review and dose-response meta-analysis of cohort studies. Nutr Metab Cardiovasc Dis. 2021;31(9):2526-2538.
Shahinfar, H., Jayedi, A., Khan, T. A., & Shab-Bidar, S. (2021). Coffee consumption and cardiovascular diseases and mortality in patients with type 2 diabetes: A systematic review and dose-response meta-analysis of cohort studies. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 31(9), 2526-2538. https://doi.org/10.1016/j.numecd.2021.05.014
Shahinfar H, et al. Coffee Consumption and Cardiovascular Diseases and Mortality in Patients With Type 2 Diabetes: a Systematic Review and Dose-response Meta-analysis of Cohort Studies. Nutr Metab Cardiovasc Dis. 2021 08 26;31(9):2526-2538. PubMed PMID: 34112583.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee consumption and cardiovascular diseases and mortality in patients with type 2 diabetes: A systematic review and dose-response meta-analysis of cohort studies. AU - Shahinfar,Hossein, AU - Jayedi,Ahmad, AU - Khan,Tauseef A, AU - Shab-Bidar,Sakineh, Y1 - 2021/05/24/ PY - 2021/03/04/received PY - 2021/05/08/revised PY - 2021/05/11/accepted PY - 2021/6/12/pubmed PY - 2021/10/6/medline PY - 2021/6/11/entrez KW - All-cause mortality KW - CVD mortality KW - Coffee KW - Cohort studies KW - Dose–response meta-analysis SP - 2526 EP - 2538 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 31 IS - 9 N2 - AIMS: To evaluate the long-term consequences of coffee drinking in patients with type 2 diabetes. DATA SYNTHESIS: PubMed, Scopus, and Web of Sciences were searched to November 2020 for prospective cohort studies evaluating the association of coffee drinking with risk of cardiovascular disease (CVD) and mortality in patients with type 2 diabetes. Two reviewers extracted data and rated the certainty of evidence using GRADE approach. Random-effects models were used to estimate the hazard ratios (HRs) and 95% CIs. Dose-response associations were modeled by a one-stage mixed-effects meta-analysis. Ten prospective cohort studies with 82,270 cases were included. Compared to those with no coffee consumption, the HRs for consumption of 4 cups/d were 0.79 (95%CI: 0.72, 0.87; n = 10 studies) for all-cause mortality, 0.60 (95%CI: 0.46, 0.79; n = 4) for CVD mortality, 0.68 (95%CI: 0.51, 0.91; n = 3) for coronary heart disease (CHD) mortality, 0.72 (95%CI: 0.54, 0.98; n = 2) for CHD, and 0.77 (95%CI: 0.61, 0.98; n = 2) for total CVD events. There was no significant association for cancer mortality and stroke. There was an inverse monotonic association between coffee drinking and all-cause and CVD mortality, and inverse linear association for CHD and total CVD events. The certainty of evidence was graded moderate for all-cause mortality, and low or very low for other outcomes. CONCLUSIONS: Drinking coffee may be inversely associated with the risk of mortality in patients with type 2 diabetes. However, more research is needed considering type of coffee, sugar and cream added to coffee, and history of CVD to present more confident results. REGISTRY AND REGISTRY NUMBER: The protocol of this systematic review was registered at Open Science Framework (https://osf.io/8uaf3, registered form: osf.io/xur76, registration DOI: 10.17605/OSF.IO/8UAF3). SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/34112583/Coffee_consumption_and_cardiovascular_diseases_and_mortality_in_patients_with_type_2_diabetes:_A_systematic_review_and_dose_response_meta_analysis_of_cohort_studies_ DB - PRIME DP - Unbound Medicine ER -