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The lethal internal face of the coronaviruses: Kidney tropism of the SARS, MERS, and COVID19 viruses.
IUBMB Life. 2021 Aug; 73(8):1005-1015.IL

Abstract

The kidney is one of the main targets attacked by viruses in patients with a coronavirus infection. Until now, SARS-CoV-2 has been identified as the seventh member of the coronavirus family capable of infecting humans. In the past two decades, humankind has experienced outbreaks triggered by two other extremely infective members of the coronavirus family; the MERS-CoV and the SARS-CoV. According to several investigations, SARS-CoV causes proteinuria and renal impairment or failure. The SARS-CoV was identified in the distal convoluted tubules of the kidney of infected patients. Also, renal dysfunction was observed in numerous cases of MERS-CoV infection. And recently, during the 2019-nCoV pandemic, it was found that the novel coronavirus not only induces acute respiratory distress syndrome (ARDS) but also can induce damages in various organs including the liver, heart, and kidney. The kidney tissue and its cells are targeted massively by the coronaviruses due to the abundant presence of ACE2 and Dpp4 receptors on kidney cells. These receptors are characterized as the main route of coronavirus entry to the victim cells. Renal failure due to massive viral invasion can lead to undesirable complications and enhanced mortality rate, thus more attention should be paid to the pathology of coronaviruses in the kidney. Here, we have provided the most recent knowledge on the coronaviruses (SARS, MERS, and COVID19) pathology and the mechanisms of their impact on the kidney tissue and functions.

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Authors+Show Affiliations

Motavalli R
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Abdelbasset WK
Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia. Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt.
Rahman HS
Department of Physiology, College of Medicine, University of Sulaimani, Suleimanyah, Iraq.
Achmad MH
Department of Pediatric Dentistry, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia.
Sergeevna NK
Department of postgraduate and doctoral studies, Russian New University, Moscow, Russia.
Zekiy AO
Sechenov First Moscow State Medical University, Moscow, Russian Federation.
Adili A
Department of oncology, Tabriz University of Medical Sciences, Tabriz, Iran.
Khiavi FM
Department of Virology, Pasteur Institute of Iran, Tehran, Iran.
Marofi F
Department of Immunology, Division of Hematology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Yousefi M
Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Ghoreishizadeh S
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Shomali N
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Etemadi J
Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Jarahian M
Toxicology and Chemotherapy Unit (G401), German Cancer Research Center (DKFZ), Heidelberg, Germany.

MeSH

Angiotensin-Converting Enzyme 2COVID-19Coronavirus InfectionsDipeptidyl Peptidase 4Gene Expression RegulationHumansKidneyMiddle East Respiratory Syndrome CoronavirusProtein BindingReceptors, VirusSevere acute respiratory syndrome-related coronavirusSARS-CoV-2Severe Acute Respiratory SyndromeSeverity of Illness IndexSpike Glycoprotein, CoronavirusSurvival AnalysisViral Tropism

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

34118117

Citation

Motavalli, Roza, et al. "The Lethal Internal Face of the Coronaviruses: Kidney Tropism of the SARS, MERS, and COVID19 Viruses." IUBMB Life, vol. 73, no. 8, 2021, pp. 1005-1015.
Motavalli R, Abdelbasset WK, Rahman HS, et al. The lethal internal face of the coronaviruses: Kidney tropism of the SARS, MERS, and COVID19 viruses. IUBMB Life. 2021;73(8):1005-1015.
Motavalli, R., Abdelbasset, W. K., Rahman, H. S., Achmad, M. H., Sergeevna, N. K., Zekiy, A. O., Adili, A., Khiavi, F. M., Marofi, F., Yousefi, M., Ghoreishizadeh, S., Shomali, N., Etemadi, J., & Jarahian, M. (2021). The lethal internal face of the coronaviruses: Kidney tropism of the SARS, MERS, and COVID19 viruses. IUBMB Life, 73(8), 1005-1015. https://doi.org/10.1002/iub.2516
Motavalli R, et al. The Lethal Internal Face of the Coronaviruses: Kidney Tropism of the SARS, MERS, and COVID19 Viruses. IUBMB Life. 2021;73(8):1005-1015. PubMed PMID: 34118117.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The lethal internal face of the coronaviruses: Kidney tropism of the SARS, MERS, and COVID19 viruses. AU - Motavalli,Roza, AU - Abdelbasset,Walid Kamal, AU - Rahman,Heshu Sulaiman, AU - Achmad,Muhammad Harun, AU - Sergeevna,Nataliya Klunko, AU - Zekiy,Angelina Olegovna, AU - Adili,Ali, AU - Khiavi,Farhad Motavalli, AU - Marofi,Faroogh, AU - Yousefi,Mehdi, AU - Ghoreishizadeh,Shadi, AU - Shomali,Navid, AU - Etemadi,Jalal, AU - Jarahian,Mostafa, Y1 - 2021/06/30/ PY - 2021/6/6/revised PY - 2021/5/1/received PY - 2021/6/8/accepted PY - 2021/6/13/pubmed PY - 2021/8/7/medline PY - 2021/6/12/entrez KW - COVID19 KW - MERS KW - SARS KW - kidney KW - viral infection SP - 1005 EP - 1015 JF - IUBMB life JO - IUBMB Life VL - 73 IS - 8 N2 - The kidney is one of the main targets attacked by viruses in patients with a coronavirus infection. Until now, SARS-CoV-2 has been identified as the seventh member of the coronavirus family capable of infecting humans. In the past two decades, humankind has experienced outbreaks triggered by two other extremely infective members of the coronavirus family; the MERS-CoV and the SARS-CoV. According to several investigations, SARS-CoV causes proteinuria and renal impairment or failure. The SARS-CoV was identified in the distal convoluted tubules of the kidney of infected patients. Also, renal dysfunction was observed in numerous cases of MERS-CoV infection. And recently, during the 2019-nCoV pandemic, it was found that the novel coronavirus not only induces acute respiratory distress syndrome (ARDS) but also can induce damages in various organs including the liver, heart, and kidney. The kidney tissue and its cells are targeted massively by the coronaviruses due to the abundant presence of ACE2 and Dpp4 receptors on kidney cells. These receptors are characterized as the main route of coronavirus entry to the victim cells. Renal failure due to massive viral invasion can lead to undesirable complications and enhanced mortality rate, thus more attention should be paid to the pathology of coronaviruses in the kidney. Here, we have provided the most recent knowledge on the coronaviruses (SARS, MERS, and COVID19) pathology and the mechanisms of their impact on the kidney tissue and functions. SN - 1521-6551 UR - https://www.unboundmedicine.com/medline/citation/34118117/The_lethal_internal_face_of_the_coronaviruses:_Kidney_tropism_of_the_SARS_MERS_and_COVID19_viruses_ DB - PRIME DP - Unbound Medicine ER -