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Seroprevalence and SARS-CoV-2 cross-reactivity of endemic coronavirus OC43 and 229E antibodies in Finnish children and adults.
Clin Immunol. 2021 08; 229:108782.CI

Abstract

Endemic human coronaviruses (hCoVs) are common causative agents of respiratory tract infections, affecting especially children. However, in the ongoing SARS-CoV-2 pandemic, children are the least affected age-group. The objective of this study was to investigate the magnitude of endemic hCoVs antibodies in Finnish children and adults, and pre-pandemic antibody cross-reactivity with SARS-CoV-2. Antibody levels against endemic hCoVs start to rise at a very early age, reaching to overall 100% seroprevalence. No difference in the antibody levels was detected for OC43 but the magnitude of 229E-specific antibodies was significantly higher in the sera of children. OC43 and 229E hCoV antibody levels of children correlated significantly with each other and with the level of cross-reactive SARS-CoV-2 antibodies, whereas these correlations completely lacked in adults. Although none of the sera showed SARS-CoV-2 neutralization, the higher overall hCoV cross-reactivity observed in children might, at least partially, contribute in controlling SARS-CoV-2 infection in this population.

Authors+Show Affiliations

Vaccine Development and Immunology/Vaccine Research Center, Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu 34, FI-33520 Tampere, Finland. Electronic address: kirsi.tamminen@tuni.fi.Vaccine Development and Immunology/Vaccine Research Center, Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu 34, FI-33520 Tampere, Finland. Electronic address: marjo.salminen@tuni.fi.Vaccine Development and Immunology/Vaccine Research Center, Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu 34, FI-33520 Tampere, Finland. Electronic address: vesna.blazevic@tuni.fi.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

34118402

Citation

Tamminen, Kirsi, et al. "Seroprevalence and SARS-CoV-2 Cross-reactivity of Endemic Coronavirus OC43 and 229E Antibodies in Finnish Children and Adults." Clinical Immunology (Orlando, Fla.), vol. 229, 2021, p. 108782.
Tamminen K, Salminen M, Blazevic V. Seroprevalence and SARS-CoV-2 cross-reactivity of endemic coronavirus OC43 and 229E antibodies in Finnish children and adults. Clin Immunol. 2021;229:108782.
Tamminen, K., Salminen, M., & Blazevic, V. (2021). Seroprevalence and SARS-CoV-2 cross-reactivity of endemic coronavirus OC43 and 229E antibodies in Finnish children and adults. Clinical Immunology (Orlando, Fla.), 229, 108782. https://doi.org/10.1016/j.clim.2021.108782
Tamminen K, Salminen M, Blazevic V. Seroprevalence and SARS-CoV-2 Cross-reactivity of Endemic Coronavirus OC43 and 229E Antibodies in Finnish Children and Adults. Clin Immunol. 2021;229:108782. PubMed PMID: 34118402.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seroprevalence and SARS-CoV-2 cross-reactivity of endemic coronavirus OC43 and 229E antibodies in Finnish children and adults. AU - Tamminen,Kirsi, AU - Salminen,Marjo, AU - Blazevic,Vesna, Y1 - 2021/06/09/ PY - 2021/04/16/received PY - 2021/05/11/revised PY - 2021/06/07/accepted PY - 2021/6/13/pubmed PY - 2021/8/13/medline PY - 2021/6/12/entrez KW - 229E KW - Coronavirus KW - Cross-reactivity KW - OC43 KW - SARS-CoV-2 KW - Serology SP - 108782 EP - 108782 JF - Clinical immunology (Orlando, Fla.) JO - Clin Immunol VL - 229 N2 - Endemic human coronaviruses (hCoVs) are common causative agents of respiratory tract infections, affecting especially children. However, in the ongoing SARS-CoV-2 pandemic, children are the least affected age-group. The objective of this study was to investigate the magnitude of endemic hCoVs antibodies in Finnish children and adults, and pre-pandemic antibody cross-reactivity with SARS-CoV-2. Antibody levels against endemic hCoVs start to rise at a very early age, reaching to overall 100% seroprevalence. No difference in the antibody levels was detected for OC43 but the magnitude of 229E-specific antibodies was significantly higher in the sera of children. OC43 and 229E hCoV antibody levels of children correlated significantly with each other and with the level of cross-reactive SARS-CoV-2 antibodies, whereas these correlations completely lacked in adults. Although none of the sera showed SARS-CoV-2 neutralization, the higher overall hCoV cross-reactivity observed in children might, at least partially, contribute in controlling SARS-CoV-2 infection in this population. SN - 1521-7035 UR - https://www.unboundmedicine.com/medline/citation/34118402/Seroprevalence_and_SARS_CoV_2_cross_reactivity_of_endemic_coronavirus_OC43_and_229E_antibodies_in_Finnish_children_and_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6616(21)00119-4 DB - PRIME DP - Unbound Medicine ER -