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The Interaction Between Microglia and Macroglia in Glaucoma.
Front Neurosci. 2021; 15:610788.FN

Abstract

Glaucoma, a neurodegenerative disease that leads to irreversible vision loss, is characterized by progressive loss of retinal ganglion cells (RGCs) and optic axons. To date, elevated intraocular pressure (IOP) has been recognized as the main phenotypic factor associated with glaucoma. However, some patients with normal IOP also have glaucomatous visual impairment and RGC loss. Unfortunately, the underlying mechanisms behind such cases remain unclear. Recent studies have suggested that retinal glia play significant roles in the initiation and progression of glaucoma. Multiple types of glial cells are activated in glaucoma. Microglia, for example, act as critical mediators that orchestrate the progression of neuroinflammation through pro-inflammatory cytokines. In contrast, macroglia (astrocytes and Müller cells) participate in retinal inflammatory responses as modulators and contribute to neuroprotection through the secretion of neurotrophic factors. Notably, research results have indicated that intricate interactions between microglia and macroglia might provide potential therapeutic targets for the prevention and treatment of glaucoma. In this review, we examine the specific roles of microglia and macroglia in open-angle glaucoma, including glaucoma in animal models, and analyze the interaction between these two cell types. In addition, we discuss potential treatment options based on the relationship between glial cells and neurons.

Authors+Show Affiliations

Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai General Hospital, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China.Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai General Hospital, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China.Department of Immunology and Microbiology, Shanghai General Hospital, The Center for Microbiota and Immunological Diseases, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai General Hospital, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

34121982

Citation

Zhao, Xiaohuan, et al. "The Interaction Between Microglia and Macroglia in Glaucoma." Frontiers in Neuroscience, vol. 15, 2021, p. 610788.
Zhao X, Sun R, Luo X, et al. The Interaction Between Microglia and Macroglia in Glaucoma. Front Neurosci. 2021;15:610788.
Zhao, X., Sun, R., Luo, X., Wang, F., & Sun, X. (2021). The Interaction Between Microglia and Macroglia in Glaucoma. Frontiers in Neuroscience, 15, 610788. https://doi.org/10.3389/fnins.2021.610788
Zhao X, et al. The Interaction Between Microglia and Macroglia in Glaucoma. Front Neurosci. 2021;15:610788. PubMed PMID: 34121982.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Interaction Between Microglia and Macroglia in Glaucoma. AU - Zhao,Xiaohuan, AU - Sun,Rou, AU - Luo,Xueting, AU - Wang,Feng, AU - Sun,Xiaodong, Y1 - 2021/05/28/ PY - 2020/09/27/received PY - 2021/04/22/accepted PY - 2021/6/14/entrez PY - 2021/6/15/pubmed PY - 2021/6/15/medline KW - Müller cells KW - astrocytes KW - glaucoma KW - macroglia KW - microglia KW - neuroinflammation SP - 610788 EP - 610788 JF - Frontiers in neuroscience JO - Front Neurosci VL - 15 N2 - Glaucoma, a neurodegenerative disease that leads to irreversible vision loss, is characterized by progressive loss of retinal ganglion cells (RGCs) and optic axons. To date, elevated intraocular pressure (IOP) has been recognized as the main phenotypic factor associated with glaucoma. However, some patients with normal IOP also have glaucomatous visual impairment and RGC loss. Unfortunately, the underlying mechanisms behind such cases remain unclear. Recent studies have suggested that retinal glia play significant roles in the initiation and progression of glaucoma. Multiple types of glial cells are activated in glaucoma. Microglia, for example, act as critical mediators that orchestrate the progression of neuroinflammation through pro-inflammatory cytokines. In contrast, macroglia (astrocytes and Müller cells) participate in retinal inflammatory responses as modulators and contribute to neuroprotection through the secretion of neurotrophic factors. Notably, research results have indicated that intricate interactions between microglia and macroglia might provide potential therapeutic targets for the prevention and treatment of glaucoma. In this review, we examine the specific roles of microglia and macroglia in open-angle glaucoma, including glaucoma in animal models, and analyze the interaction between these two cell types. In addition, we discuss potential treatment options based on the relationship between glial cells and neurons. SN - 1662-4548 UR - https://www.unboundmedicine.com/medline/citation/34121982/The_Interaction_Between_Microglia_and_Macroglia_in_Glaucoma_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/34121982/ DB - PRIME DP - Unbound Medicine ER -
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