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Deep venous contribution to hydrostatic blood volume change in the human leg.
Am J Cardiol. 1988 Sep 01; 62(7):449-53.AJ

Abstract

The causes of orthostatic intolerance following prolonged bed rest, head-down tilt or exposure to zero gravity are not completely understood. One possible contributing mechanism is increased venous compliance and peripheral venous pooling. The present study attempted to determine what proportion of the increased calf volume during progressive venous occlusion is due to deep venous filling. Deep veins in the leg have little sympathetic innervation and scant vascular smooth muscle, so their compliance may be determined primarily by the surrounding skeletal muscle. If deep veins make a large contribution to total leg venous compliance, then disuse-related changes in skeletal muscle mass and tone could increase leg compliance and lead to decreased orthostatic tolerance. The increase in deep venous volume during progressive venous occlusion at the knee was measured in 6 normal subjects using calf cross-sectional images obtained with magnetic resonance imaging. Conventional plethysmography was used simultaneously to give an independent second measurement of leg volume and monitor the time course of the volume changes. Most of the volume change at all occlusion levels (20, 40, 60, 80 and 100 mm Hg) could be attributed to deep venous filling (90.2% at 40 mm Hg and 50.6% at 100 mm Hg). It is concluded that a large fraction of the calf volume change during venous occlusion is attributable to filling of the deep venous spaces. This finding supports theories postulating an important role for physiological mechanisms controlling skeletal muscle tone during orthostatic stress.

Authors+Show Affiliations

Pauline and Adolph Weinberger Laboratory for Cardiopulmonary Research, Department of Internal Medicine/Cardiology, University of Texas Southwestern Medical Center, Dallas 75235-9034.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3414521

Citation

Buckey, J C., et al. "Deep Venous Contribution to Hydrostatic Blood Volume Change in the Human Leg." The American Journal of Cardiology, vol. 62, no. 7, 1988, pp. 449-53.
Buckey JC, Peshock RM, Blomqvist CG. Deep venous contribution to hydrostatic blood volume change in the human leg. Am J Cardiol. 1988;62(7):449-53.
Buckey, J. C., Peshock, R. M., & Blomqvist, C. G. (1988). Deep venous contribution to hydrostatic blood volume change in the human leg. The American Journal of Cardiology, 62(7), 449-53.
Buckey JC, Peshock RM, Blomqvist CG. Deep Venous Contribution to Hydrostatic Blood Volume Change in the Human Leg. Am J Cardiol. 1988 Sep 1;62(7):449-53. PubMed PMID: 3414521.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deep venous contribution to hydrostatic blood volume change in the human leg. AU - Buckey,J C, AU - Peshock,R M, AU - Blomqvist,C G, PY - 1988/9/1/pubmed PY - 1988/9/1/medline PY - 1988/9/1/entrez SP - 449 EP - 53 JF - The American journal of cardiology JO - Am J Cardiol VL - 62 IS - 7 N2 - The causes of orthostatic intolerance following prolonged bed rest, head-down tilt or exposure to zero gravity are not completely understood. One possible contributing mechanism is increased venous compliance and peripheral venous pooling. The present study attempted to determine what proportion of the increased calf volume during progressive venous occlusion is due to deep venous filling. Deep veins in the leg have little sympathetic innervation and scant vascular smooth muscle, so their compliance may be determined primarily by the surrounding skeletal muscle. If deep veins make a large contribution to total leg venous compliance, then disuse-related changes in skeletal muscle mass and tone could increase leg compliance and lead to decreased orthostatic tolerance. The increase in deep venous volume during progressive venous occlusion at the knee was measured in 6 normal subjects using calf cross-sectional images obtained with magnetic resonance imaging. Conventional plethysmography was used simultaneously to give an independent second measurement of leg volume and monitor the time course of the volume changes. Most of the volume change at all occlusion levels (20, 40, 60, 80 and 100 mm Hg) could be attributed to deep venous filling (90.2% at 40 mm Hg and 50.6% at 100 mm Hg). It is concluded that a large fraction of the calf volume change during venous occlusion is attributable to filling of the deep venous spaces. This finding supports theories postulating an important role for physiological mechanisms controlling skeletal muscle tone during orthostatic stress. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/3414521/Deep_venous_contribution_to_hydrostatic_blood_volume_change_in_the_human_leg_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0002-9149(88)90976-9 DB - PRIME DP - Unbound Medicine ER -