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Eustachian tube function associated with histamine-induced and ragweed-induced rhinitis.
Ann Allergy. 1988 Sep; 61(3):234-8.AA

Abstract

Nasal allergies may contribute to Eustachian tube dysfunction and chronic middle ear problems. In exploring this association further, Eustachian tube function was measured in ten ragweed-allergic and eight non-allergic patients undergoing repetitive nasal provocation. Anterior nasal provocation was done using paper disks impregnated with either histamine or aqueous ragweed allergen. Increasing concentrations of the provocative agent were placed on both inferior nasal turbinates until moderate symptoms of rhinitis developed. Eustachian tube function was evaluated using the 9-step inflation-deflation tympanometric test before and immediately after each nasal challenge. Eustachian obstruction developed in 4 of 38 non-allergic ears during histamine nasal provocation. With ragweed nasal challenge, 9 of 42 allergic ears developed Eustachian tube obstruction. Four allergic ears gained Eustachian tube function despite being obstructed before the challenge. The observed changes in ear function for both groups were not significant due to variability in Eustachian response. At the concentrations which initiated symptoms of rhinitis, nasal provocation with histamine or ragweed did not consistently obstruct the Eustachian tube. We conclude that mild symptoms of allergic rhinitis may not cause significant Eustachian tube obstruction.

Authors+Show Affiliations

Georgitis JW
Department of Pediatrics, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina.
Gold SM
No affiliation info available
Bernstein JM
No affiliation info available

MeSH

Airway ResistanceEustachian TubeHistamineHumansHypersensitivityNasal Provocation TestsOsmolar ConcentrationPollenReference ValuesRhinitis

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3415055

Citation

Georgitis, J W., et al. "Eustachian Tube Function Associated With Histamine-induced and Ragweed-induced Rhinitis." Annals of Allergy, vol. 61, no. 3, 1988, pp. 234-8.
Georgitis JW, Gold SM, Bernstein JM. Eustachian tube function associated with histamine-induced and ragweed-induced rhinitis. Ann Allergy. 1988;61(3):234-8.
Georgitis, J. W., Gold, S. M., & Bernstein, J. M. (1988). Eustachian tube function associated with histamine-induced and ragweed-induced rhinitis. Annals of Allergy, 61(3), 234-8.
Georgitis JW, Gold SM, Bernstein JM. Eustachian Tube Function Associated With Histamine-induced and Ragweed-induced Rhinitis. Ann Allergy. 1988;61(3):234-8. PubMed PMID: 3415055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eustachian tube function associated with histamine-induced and ragweed-induced rhinitis. AU - Georgitis,J W, AU - Gold,S M, AU - Bernstein,J M, PY - 1988/9/1/pubmed PY - 1988/9/1/medline PY - 1988/9/1/entrez SP - 234 EP - 8 JF - Annals of allergy JO - Ann Allergy VL - 61 IS - 3 N2 - Nasal allergies may contribute to Eustachian tube dysfunction and chronic middle ear problems. In exploring this association further, Eustachian tube function was measured in ten ragweed-allergic and eight non-allergic patients undergoing repetitive nasal provocation. Anterior nasal provocation was done using paper disks impregnated with either histamine or aqueous ragweed allergen. Increasing concentrations of the provocative agent were placed on both inferior nasal turbinates until moderate symptoms of rhinitis developed. Eustachian tube function was evaluated using the 9-step inflation-deflation tympanometric test before and immediately after each nasal challenge. Eustachian obstruction developed in 4 of 38 non-allergic ears during histamine nasal provocation. With ragweed nasal challenge, 9 of 42 allergic ears developed Eustachian tube obstruction. Four allergic ears gained Eustachian tube function despite being obstructed before the challenge. The observed changes in ear function for both groups were not significant due to variability in Eustachian response. At the concentrations which initiated symptoms of rhinitis, nasal provocation with histamine or ragweed did not consistently obstruct the Eustachian tube. We conclude that mild symptoms of allergic rhinitis may not cause significant Eustachian tube obstruction. SN - 0003-4738 UR - https://www.unboundmedicine.com/medline/citation/3415055/Eustachian_tube_function_associated_with_histamine_induced_and_ragweed_induced_rhinitis_ DB - PRIME DP - Unbound Medicine ER -