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Water-stable zirconium-based metal-organic frameworks armed polyvinyl alcohol nanofibrous membrane with enhanced antibacterial therapy for wound healing.
J Colloid Interface Sci. 2021 Dec; 603:243-251.JC

Abstract

Inadequate water-stability and antibacterial activity limit the biomedical application of polyvinyl alcohol (PVA)-based membranes in moist environments. In this work, we propose a strategy to improve the water-stability of PVA membranes via metal complexation and heat treatment. We report a simple routine where the zirconium-based UiO-66-NH2 metal-organic frameworks (MOFs) are nucleated as a layer on the surface of PVA nanofibrous membranes (UiO-66-NH2@PVA NFMs). We find that the chemical modification of membranes increases their hydrophilicity and adds on mechanical support for the brittle UiO-66-NH2 MOFs. Additionally, we demonstrate the application of UiO-66-NH2 MOFs as drug carriers for antibacterial drug, levofloxacin (LV). The active drug component is preloaded during the one-step nucleation process. The obtained LV loaded UiO-66-NH2@PVA NFMs (LV@UiO-66-NH2@PVA) are shown to be bactericidal with the efficiency > 99.9% at 100 μg/mL against two bacterial species, Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Compared with the commercially available gauzes, the UiO-66-NH2@PVA and LV@UiO-66-NH2@PVA treatments will significantly improve the wound healing process. Animal studies show that the LV@UiO-66-NH2@PVA will effectively offer a safe alternative solution for the patients to protect against bacterial infections, demonstrating the potential application of MOF-based NFMs as wound dressing agents.

Authors+Show Affiliations

School of Textiles and Fashion, Shanghai University of Engineering Science, Shanghai 201620, China.Innovation Center for Textile Science and Technology, Donghua University, Shanghai 200051, China; Key Laboratory of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China.School of Textiles and Fashion, Shanghai University of Engineering Science, Shanghai 201620, China.School of Textiles and Fashion, Shanghai University of Engineering Science, Shanghai 201620, China.Innovation Center for Textile Science and Technology, Donghua University, Shanghai 200051, China; Key Laboratory of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China.Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, United States.Innovation Center for Textile Science and Technology, Donghua University, Shanghai 200051, China. Electronic address: jyyu@dhu.edu.cn.Innovation Center for Textile Science and Technology, Donghua University, Shanghai 200051, China; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. Electronic address: zjdai@dhu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34186401

Citation

Zhu, Jie, et al. "Water-stable Zirconium-based Metal-organic Frameworks Armed Polyvinyl Alcohol Nanofibrous Membrane With Enhanced Antibacterial Therapy for Wound Healing." Journal of Colloid and Interface Science, vol. 603, 2021, pp. 243-251.
Zhu J, Qiu W, Yao C, et al. Water-stable zirconium-based metal-organic frameworks armed polyvinyl alcohol nanofibrous membrane with enhanced antibacterial therapy for wound healing. J Colloid Interface Sci. 2021;603:243-251.
Zhu, J., Qiu, W., Yao, C., Wang, C., Wu, D., Pradeep, S., Yu, J., & Dai, Z. (2021). Water-stable zirconium-based metal-organic frameworks armed polyvinyl alcohol nanofibrous membrane with enhanced antibacterial therapy for wound healing. Journal of Colloid and Interface Science, 603, 243-251. https://doi.org/10.1016/j.jcis.2021.06.084
Zhu J, et al. Water-stable Zirconium-based Metal-organic Frameworks Armed Polyvinyl Alcohol Nanofibrous Membrane With Enhanced Antibacterial Therapy for Wound Healing. J Colloid Interface Sci. 2021;603:243-251. PubMed PMID: 34186401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Water-stable zirconium-based metal-organic frameworks armed polyvinyl alcohol nanofibrous membrane with enhanced antibacterial therapy for wound healing. AU - Zhu,Jie, AU - Qiu,Weiwang, AU - Yao,Chengjian, AU - Wang,Chun, AU - Wu,Dequn, AU - Pradeep,Shravan, AU - Yu,Jianyong, AU - Dai,Zijian, Y1 - 2021/06/16/ PY - 2021/04/20/received PY - 2021/06/11/revised PY - 2021/06/12/accepted PY - 2021/6/30/pubmed PY - 2021/9/22/medline PY - 2021/6/29/entrez KW - Antibacterial wound dressing KW - Polyvinyl alcohol KW - UiO-66-NH(2) KW - Water-stable SP - 243 EP - 251 JF - Journal of colloid and interface science JO - J Colloid Interface Sci VL - 603 N2 - Inadequate water-stability and antibacterial activity limit the biomedical application of polyvinyl alcohol (PVA)-based membranes in moist environments. In this work, we propose a strategy to improve the water-stability of PVA membranes via metal complexation and heat treatment. We report a simple routine where the zirconium-based UiO-66-NH2 metal-organic frameworks (MOFs) are nucleated as a layer on the surface of PVA nanofibrous membranes (UiO-66-NH2@PVA NFMs). We find that the chemical modification of membranes increases their hydrophilicity and adds on mechanical support for the brittle UiO-66-NH2 MOFs. Additionally, we demonstrate the application of UiO-66-NH2 MOFs as drug carriers for antibacterial drug, levofloxacin (LV). The active drug component is preloaded during the one-step nucleation process. The obtained LV loaded UiO-66-NH2@PVA NFMs (LV@UiO-66-NH2@PVA) are shown to be bactericidal with the efficiency > 99.9% at 100 μg/mL against two bacterial species, Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Compared with the commercially available gauzes, the UiO-66-NH2@PVA and LV@UiO-66-NH2@PVA treatments will significantly improve the wound healing process. Animal studies show that the LV@UiO-66-NH2@PVA will effectively offer a safe alternative solution for the patients to protect against bacterial infections, demonstrating the potential application of MOF-based NFMs as wound dressing agents. SN - 1095-7103 UR - https://www.unboundmedicine.com/medline/citation/34186401/Water_stable_zirconium_based_metal_organic_frameworks_armed_polyvinyl_alcohol_nanofibrous_membrane_with_enhanced_antibacterial_therapy_for_wound_healing_ DB - PRIME DP - Unbound Medicine ER -