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Rapid SERS Quantification of Trace Fentanyl Laced in Recreational Drugs with a Portable Raman Module.
Anal Chem. 2021 07 13; 93(27):9373-9382.AC

Abstract

Rapid identification and quantification of opioid drugs are of significant importance and an urgent need in drug regulation and control, considering the serious social and economic impact of the opioid epidemic in the United States. Unfortunately, techniques for accurate detection of these opioids, particularly for fentanyl, an extremely potent synthetic drug of abuse and a main perpetrator in the opioid crisis, are often not readily accessible. Therefore, a fast, highly sensitive, and preferably quantitative technique, with excellent portability, is highly desirable. Such a technique can potentially offer timely and crucial information for drug control officials, as well as health professionals, about drug distribution and overdose prevention. We therefore propose a portable surface-enhanced Raman scattering (SERS) approach by pairing an easy to perform yet reliable SERS protocol with a compact Raman module suitable for rapid, on-site identification and quantification of trace fentanyl. Fentanyl spiked in urine control was successfully detected at concentrations as low as 5 ng/mL. Portable SERS also enabled detection of trace fentanyl laced in recreational drugs at mass concentrations as low as 0.05% (5 ng in 10 μg total) and 0.1% (10 ng in 10 μg total) in heroin and tetrahydrocannabinol (THC), respectively. Drug interaction with the nanoparticle surface was simulated through molecular dynamics to investigate the molecular adsorption mechanism and account for SERS signal differences observed for opioid drugs. Furthermore, resolution of fentanyl in binary and ternary opioid mixtures was readily achieved with multivariate data analysis. In sum, we developed a rapid, highly sensitive, and reliably quantitative method for trace fentanyl analysis by synergizing a streamlined SERS procedure and a portable Raman module at low cost.

Authors+Show Affiliations

Department of Materials Science and Engineering, Rutgers University, 607 Taylor Road, Piscataway, New Jersey 08854, United States.Department of Materials Science and Engineering, Rutgers University, 607 Taylor Road, Piscataway, New Jersey 08854, United States.Department of Chemistry and Chemical Biology, Rutgers University, 123 Bevier Road, Piscataway, New Jersey 08854, United States.Hamamatsu Corporation, 360 Foothill Road, Bridgewater, New Jersey 08807, United States.Department of Chemistry and Chemical Biology, Rutgers University, 123 Bevier Road, Piscataway, New Jersey 08854, United States.Department of Materials Science and Engineering, Rutgers University, 607 Taylor Road, Piscataway, New Jersey 08854, United States.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

34191499

Citation

Wang, Hao, et al. "Rapid SERS Quantification of Trace Fentanyl Laced in Recreational Drugs With a Portable Raman Module." Analytical Chemistry, vol. 93, no. 27, 2021, pp. 9373-9382.
Wang H, Xue Z, Wu Y, et al. Rapid SERS Quantification of Trace Fentanyl Laced in Recreational Drugs with a Portable Raman Module. Anal Chem. 2021;93(27):9373-9382.
Wang, H., Xue, Z., Wu, Y., Gilmore, J., Wang, L., & Fabris, L. (2021). Rapid SERS Quantification of Trace Fentanyl Laced in Recreational Drugs with a Portable Raman Module. Analytical Chemistry, 93(27), 9373-9382. https://doi.org/10.1021/acs.analchem.1c00792
Wang H, et al. Rapid SERS Quantification of Trace Fentanyl Laced in Recreational Drugs With a Portable Raman Module. Anal Chem. 2021 07 13;93(27):9373-9382. PubMed PMID: 34191499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rapid SERS Quantification of Trace Fentanyl Laced in Recreational Drugs with a Portable Raman Module. AU - Wang,Hao, AU - Xue,Zhaolin, AU - Wu,Yuxuan, AU - Gilmore,John, AU - Wang,Lu, AU - Fabris,Laura, Y1 - 2021/06/30/ PY - 2021/7/1/pubmed PY - 2021/7/22/medline PY - 2021/6/30/entrez SP - 9373 EP - 9382 JF - Analytical chemistry JO - Anal Chem VL - 93 IS - 27 N2 - Rapid identification and quantification of opioid drugs are of significant importance and an urgent need in drug regulation and control, considering the serious social and economic impact of the opioid epidemic in the United States. Unfortunately, techniques for accurate detection of these opioids, particularly for fentanyl, an extremely potent synthetic drug of abuse and a main perpetrator in the opioid crisis, are often not readily accessible. Therefore, a fast, highly sensitive, and preferably quantitative technique, with excellent portability, is highly desirable. Such a technique can potentially offer timely and crucial information for drug control officials, as well as health professionals, about drug distribution and overdose prevention. We therefore propose a portable surface-enhanced Raman scattering (SERS) approach by pairing an easy to perform yet reliable SERS protocol with a compact Raman module suitable for rapid, on-site identification and quantification of trace fentanyl. Fentanyl spiked in urine control was successfully detected at concentrations as low as 5 ng/mL. Portable SERS also enabled detection of trace fentanyl laced in recreational drugs at mass concentrations as low as 0.05% (5 ng in 10 μg total) and 0.1% (10 ng in 10 μg total) in heroin and tetrahydrocannabinol (THC), respectively. Drug interaction with the nanoparticle surface was simulated through molecular dynamics to investigate the molecular adsorption mechanism and account for SERS signal differences observed for opioid drugs. Furthermore, resolution of fentanyl in binary and ternary opioid mixtures was readily achieved with multivariate data analysis. In sum, we developed a rapid, highly sensitive, and reliably quantitative method for trace fentanyl analysis by synergizing a streamlined SERS procedure and a portable Raman module at low cost. SN - 1520-6882 UR - https://www.unboundmedicine.com/medline/citation/34191499/Rapid_SERS_Quantification_of_Trace_Fentanyl_Laced_in_Recreational_Drugs_with_a_Portable_Raman_Module_ L2 - https://doi.org/10.1021/acs.analchem.1c00792 DB - PRIME DP - Unbound Medicine ER -