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Aphasia seven days after second dose of an mRNA-based SARS-CoV-2 vaccine.
Brain Hemorrhages. 2021 Jun 24 [Online ahead of print]BH

Abstract

Objectives

Though rare, neurological side effects of SARS-CoV-2 vaccinations are increasingly reported. Even if the first dosage goes uncomplicated, the second dose may be complicated by severe adverse reactions as in the following case.

Case report

A 52yo male developed sudden-onset reading difficulty and aphasia 7d after the second dose of an mRNA-based SARS-CoV-2 vaccine. He had a previous history of myocardial infarction, arterial hypertension, hyperlipidemia, and nephrolithiasis. Blood pressure was slightly elevated on admission. Blood tests revealed mildly elevated D-dimer, pre-diabetes and hyperuricemia. Cerebral magnetic resonance imaging revealed an intracerebral bleeding (ICB) in the left temporal lobe. Aphasia resolved almost completely within a few days. Blood pressure values were normal throughout hospitalisation. Whether there was a causal relation between the ICB and the vaccination remains speculative but cannot be definitively excluded.

Conclusions

A second dose of a SARS-CoV-2 vaccination may be followed by ICB. Though the pathophysiology of ICB remains unexplained a causal relation between ICB and the vaccination cannot be excluded. Risk factors for ICB should be carefully monitored in patients undergoing SARS-CoV-2 vaccination.

Authors+Show Affiliations

Klinik Landstrasse, Messerli Institute, Vienna, Austria.Klinik Landstrasse, Messerli Institute, Vienna, Austria.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34192245

Citation

Finsterer, Josef, and Maria Korn. "Aphasia Seven Days After Second Dose of an mRNA-based SARS-CoV-2 Vaccine." Brain Hemorrhages, 2021.
Finsterer J, Korn M. Aphasia seven days after second dose of an mRNA-based SARS-CoV-2 vaccine. Brain Hemorrhages. 2021.
Finsterer, J., & Korn, M. (2021). Aphasia seven days after second dose of an mRNA-based SARS-CoV-2 vaccine. Brain Hemorrhages. https://doi.org/10.1016/j.hest.2021.06.001
Finsterer J, Korn M. Aphasia Seven Days After Second Dose of an mRNA-based SARS-CoV-2 Vaccine. Brain Hemorrhages. 2021 Jun 24; PubMed PMID: 34192245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aphasia seven days after second dose of an mRNA-based SARS-CoV-2 vaccine. AU - Finsterer,Josef, AU - Korn,Maria, Y1 - 2021/06/24/ PY - 2021/06/09/received PY - 2021/06/19/revised PY - 2021/06/19/accepted PY - 2021/6/30/entrez PY - 2021/7/1/pubmed PY - 2021/7/1/medline KW - Adverse reaction KW - Aphasia KW - COVID-19 KW - Intracerebral bleeding KW - SARS-CoV-2 KW - Side effect KW - Vaccination JF - Brain hemorrhages JO - Brain Hemorrhages N2 - Objectives: Though rare, neurological side effects of SARS-CoV-2 vaccinations are increasingly reported. Even if the first dosage goes uncomplicated, the second dose may be complicated by severe adverse reactions as in the following case. Case report: A 52yo male developed sudden-onset reading difficulty and aphasia 7d after the second dose of an mRNA-based SARS-CoV-2 vaccine. He had a previous history of myocardial infarction, arterial hypertension, hyperlipidemia, and nephrolithiasis. Blood pressure was slightly elevated on admission. Blood tests revealed mildly elevated D-dimer, pre-diabetes and hyperuricemia. Cerebral magnetic resonance imaging revealed an intracerebral bleeding (ICB) in the left temporal lobe. Aphasia resolved almost completely within a few days. Blood pressure values were normal throughout hospitalisation. Whether there was a causal relation between the ICB and the vaccination remains speculative but cannot be definitively excluded. Conclusions: A second dose of a SARS-CoV-2 vaccination may be followed by ICB. Though the pathophysiology of ICB remains unexplained a causal relation between ICB and the vaccination cannot be excluded. Risk factors for ICB should be carefully monitored in patients undergoing SARS-CoV-2 vaccination. SN - 2589-238X UR - https://www.unboundmedicine.com/medline/citation/34192245/Aphasia_seven_days_after_second_dose_of_an_mRNA_based_SARS_CoV_2_vaccine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2589-238X(21)00029-2 DB - PRIME DP - Unbound Medicine ER -
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