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Effect of nicergoline on learning and memory.
Methods Find Exp Clin Pharmacol. 1988 Jul; 10(7):431-5.MF

Abstract

The anti-amnestic action of nicergoline was studied using the following experimental methods for learning and memory impairment, based on passive avoidance response: amnesia induced by maximal electroshock in mice, scopolamine-induced amnesia in mice and amnesia by paradoxical sleep deprivation in rats. Piracetam, meclofenoxate, pyritinol, deanol and phenazepam were used as reference drugs. The results show that nicergoline demonstrates well-expressed anti-amnestic effect manifested by reducing the amnestic effect of maximal electroshock, scopolamine or paradoxical sleep deprivation, its effect being equal to or more pronounced than piracetam, meclofenoxate, pyritinol, deanol and phenazepam.

Authors+Show Affiliations

Voronina TA
Pharmacological Research Institute, USSR Academy of Medical Sciences, Moscow.
Nerobkova LN
No affiliation info available
Garibova TL
No affiliation info available
Dikova M
No affiliation info available
Nikolov R
No affiliation info available
Nikolova M
No affiliation info available
Markina NV
No affiliation info available

MeSH

AmnesiaAnimalsAvoidance LearningElectroshockErgolinesMaleMemoryMiceNicergolineRatsScopolamineSleep Deprivation

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3419247

Citation

Voronina, T A., et al. "Effect of Nicergoline On Learning and Memory." Methods and Findings in Experimental and Clinical Pharmacology, vol. 10, no. 7, 1988, pp. 431-5.
Voronina TA, Nerobkova LN, Garibova TL, et al. Effect of nicergoline on learning and memory. Methods Find Exp Clin Pharmacol. 1988;10(7):431-5.
Voronina, T. A., Nerobkova, L. N., Garibova, T. L., Dikova, M., Nikolov, R., Nikolova, M., & Markina, N. V. (1988). Effect of nicergoline on learning and memory. Methods and Findings in Experimental and Clinical Pharmacology, 10(7), 431-5.
Voronina TA, et al. Effect of Nicergoline On Learning and Memory. Methods Find Exp Clin Pharmacol. 1988;10(7):431-5. PubMed PMID: 3419247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of nicergoline on learning and memory. AU - Voronina,T A, AU - Nerobkova,L N, AU - Garibova,T L, AU - Dikova,M, AU - Nikolov,R, AU - Nikolova,M, AU - Markina,N V, PY - 1988/7/1/pubmed PY - 1988/7/1/medline PY - 1988/7/1/entrez SP - 431 EP - 5 JF - Methods and findings in experimental and clinical pharmacology JO - Methods Find Exp Clin Pharmacol VL - 10 IS - 7 N2 - The anti-amnestic action of nicergoline was studied using the following experimental methods for learning and memory impairment, based on passive avoidance response: amnesia induced by maximal electroshock in mice, scopolamine-induced amnesia in mice and amnesia by paradoxical sleep deprivation in rats. Piracetam, meclofenoxate, pyritinol, deanol and phenazepam were used as reference drugs. The results show that nicergoline demonstrates well-expressed anti-amnestic effect manifested by reducing the amnestic effect of maximal electroshock, scopolamine or paradoxical sleep deprivation, its effect being equal to or more pronounced than piracetam, meclofenoxate, pyritinol, deanol and phenazepam. SN - 0379-0355 UR - https://www.unboundmedicine.com/medline/citation/3419247/Effect_of_nicergoline_on_learning_and_memory_ DB - PRIME DP - Unbound Medicine ER -